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An Evaluation On Consumers' Usage Pattern of Acetaminophen (Paracetamol) : A Multicenter Study From Penang, Malaysia
An Evaluation On Consumers' Usage Pattern of Acetaminophen (Paracetamol) : A Multicenter Study From Penang, Malaysia
Abstract
Background: Acetaminophen poisoning is becoming an increasingly common social problem in Malaysia. An understanding of consumers’
usage pattern of acetaminophen is essential in addressing the issue of accidental acetaminophen poisoning. This study was therefore aimed to
evaluate the usage pattern of acetaminophen among the consumers in the state of Penang, Malaysia. Methods: A survey using a questionnaire
was carried out in Health Clinic of University Sciences Malaysia (USM), Outpatient Clinic of Advance Medical and Dental Institute, USM,
and five selected community pharmacies in the state of Penang from February 2013 to April 2013. A convenient sample of 400 Malaysian
consumers was involved in this study. Results: Majority (98.0%) of the consumers had ever taken acetaminophen. The consumers mostly
used acetaminophen for headache (75.0%) and fever (72.8%). The 500 mg acetaminophen tablet was more commonly used among the
consumers (94.3%) then the 650 mg tablet (44.3%). A total of 1.1% of the consumers had taken more than two tablets of acetaminophen
500 mg tablet per intake. Meanwhile, 24.4% of the consumers had taken two tablets or more of acetaminophen 650 mg tablet per intake. The
consumers mostly consumed acetaminophen in a frequency of either 4 hourly (29.5%), 8 hourly (17.3%) or 6 hourly (14.8%). However, 6.3%
and 7.0% of the consumers would increase the dosage or frequency of acetaminophen consumption, respectively, when their conditions or
symptoms persisted after taking the acetaminophen. Conclusions: The use of acetaminophen is prevalent among the surveyed consumers.
The risks of acetaminophen overdose were found among the consumers.
Introduction aged between 15 and 50 years and 15% of the cases were due
to accidental ingestion.[15] Besides, acetaminophen was among
Acetaminophen (paracetamol) is one of the most popular
the most common pharmaceutical agents involved in toxic
over‑the‑counter analgesic agents around the globe.[1] Most
exposures in Singapore.[16] In United Kingdom, approximately
consumers had taken acetaminophen products to treat fever,[2‑5]
48% of hospital attendances related to poisoning were involved
headache,[6] menstrual pain,[7] and common pain.[8,9] A previous
acetaminophen and it leads to 100–200 deaths annually.[17]
study in the United States showed that 78.9% of adults
There were 91 deaths out of 98,578 of all acetaminophen‑related
had used acetaminophen products in the past 6 months.[10]
poisoning cases according to data from the American
Besides, a total of 94% of Australian parents found to have
Association of Poison Control Centers in 2008.[18] Indeed, the
used acetaminophen to treat their children’s fever.[3] Efficacy,
United States Government estimated to spend US$ 87 million
availability, affordability, and past experience were among the
every year to treat acetaminophen overdosed patients.[19]
factors which driven the consumers to purchase acetaminophen
products for self‑medication.[11]
Address for correspondence: Dr. Chee Ping Chong,
Although the use of acetaminophen is generally considered Department of Clinical Pharmacy, School of Pharmaceutical Sciences,
safe, it is also the most commonly reported drugs implicated Universiti Sains Malaysia, 11800 Minden, Penang, Malaysia.
in intentional or accidental poisoning.[12‑14] A previous study E‑mail: jjueping@gmail.com
in Victoria, Australia, showed that majority of the hospital
admission for acetaminophen overdose were involved patients
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DOI: How to cite this article: Chong CP, Tan SF, Chooi WT. An evaluation on
10.4103/2045-080X.199617 consumers’ usage pattern of acetaminophen (paracetamol): A multicenter
study from Penang, Malaysia. Arch Pharma Pract 2017;8:15-21.
In Malaysia, consumers are able to treat minor illness in another section. The questionnaire was initially developed
themselves due to easy accessibility to over‑the‑counter drugs in English language and was tested for face and content
including acetaminophen.[20] However, self‑medication using validity by two experts who were academicians in the School
acetaminophen without proper information and knowledge of Pharmaceutical Sciences, USM. A forward and backward
is dangerous as this might leads to acetaminophen overdose translation was performed to translate the questionnaire into
and poisoning. Acetaminophen poisoning is becoming an Malay and Chinese language in accordance to the translation
increasingly common social problem in Malaysia and it methodology.[24] The questionnaire was further adjusted after
involves consumers from various age groups.[12] The poisoning pilot testing with five randomly selected consumers in the
requires immediate Emergency Department visits and hospital state of Penang.
admission and this places a significant burden on healthcare
During the data collection, the researcher (second author)
costs. Indeed, the poisoning could leads to severe liver injury
approached the consumers at the study sites to seek their
and even death.[17,21,22] A previous study from overseas found
participation. The data were collected from February 1, 2013
that limited health literacy is the main factor which leads to
to April 30, 2013. The study information sheet was then
inappropriate use of acetaminophen.[23] However, currently
verbally explained to the potential participants and informed
little is known about the reasons behind the acetaminophen
consent was obtained upon participant’s agreement. During
poisoning among the Malaysian consumers. The consumers
the data collection, the researcher referred to a laminated
might be unaware about the safe use of acetaminophen. An
original questionnaire that contained questions in three
understanding of consumers’ usage pattern of acetaminophen
different languages (English, Malay, and Chinese language).
is essential to the overall planning of educational interventions
Meanwhile, consumers referred to another set of the laminated
to address the misuse of acetaminophen and subsequent
original questionnaire that contains questions in three different
poisoning. Therefore, this study was to evaluate the usage
languages (English, Malay, and Chinese language). The
pattern of acetaminophen among the consumers in State of
researcher read out the questions according to the consumer’s
Penang, Malaysia. The research findings will help in addressing
preferred language and the consumers reviewed the answers
the issues around acetaminophen poisoning among the
in the questionnaire and tell the researcher of his/her choice.
consumers in Malaysia.
Subsequently, the researcher helped the consumers to fill in
nonlaminated questionnaire that contains only the English
Methods version according to the consumer’s choices. The researcher
This study was conducted with a convenient sample of explained the questions or options of the answers as well if
consumers who visited Health Clinic of University Sciences the consumer has problems understanding the questions and
Malaysia (USM), Outpatient Clinic of Advance Medical and answers. All responses were anonymous and confidential. Data
Dental Institute (AMDI), USM and five selected community analysis was performed by using PASW program for Windows
pharmacies in state of Penang, Malaysia. The study was package version 18.0 and descriptive statistic was used. This
conducted in different locations in order to recruit the consumers study was granted ethics approval from the USM‑Hospital
from different demographic background. The sample size was Lam Wah Ee Ethics Committee (ethics approval number:
calculated by using the Raosoft® software. A sample size of 400 USM‑HLWE/IEC/2012[0017]).
consumers would be able to generate results with 5% margin
of error and 95% confidence interval with 80% of the response Results
distribution. An 80% of response distribution was estimated
There were a total of 400 consumers who participated in the
based on the working experiences of the researchers of the
study. The demographic characteristics of the respondents are
present study that majority of the Malaysian consumers have
summarized in Table 1 while the usage patterns are shown
experiences in using acetaminophen. A sample of 152, 145, and
in Table 2. Nearly, all of the consumers (98.0%) had ever
103 consumers was recruited from the community pharmacies,
taken acetaminophen. Retail pharmacy (63.5%), government
USM Health Clinic and AMDI Outpatient Clinic, respectively.
hospital or clinic (48.5%), and sundry shop (26.8%) were
Consumers above the age of 13 years old and literate in either
among the common places where the consumers obtained
Malay, English, or Chinese language were included in this
their acetaminophen supply. A question was set to assess
study. Both the consumers who either have experiences in
the type of acetaminophen products used by the consumers.
using acetaminophen product or never consumed such product
A total of seven originator brands and one generic brand
were included in the study. This study excludes the healthcare
of acetaminophen products were listed as the options
practitioners and students from any medical or health field.
to choose by the respondents. The results showed that
The study design was a cross‑sectional survey which involved Panadol® (54.3%) and Panadol® Actifast (46.8%) were the
a questionnaire. The questionnaire was developed based on a most popular products among the respondents. Conversely,
literature review. The questionnaire consists of a section to only 0.5% of the respondents consumed the generic brand
assess the consumers’ demographic characteristics, whereas of acetaminophen (Uphamol ®; manufactured by CCM
the consumers’ usage pattern of acetaminophen was assessed Pharmaceutical) [Table 1].
Contd... Contd...
worrying usage patterns among the consumers, which might present study was chronic alcohol users, and they need to
place them at risk of acetaminophen poisoning. A total of 1.1% be alerted about the safety concerns in simultaneous use of
and 24.4%, respectively, of the respondents found to have acetaminophen and alcohol. Previous reports showed that
exceeded the recommended dosage per intake for 500 mg and chronic alcoholics are at risk of serious liver toxicity when
650 mg tablet. In addition, 6.3% and 7.0% of the consumers taking acetaminophen even in therapeutic doses.[32]
would increase the dosage or frequency of acetaminophen
There were some limitations in this study. The present study
consumption, respectively, when their conditions or symptoms
only recruited the consumers from the state of Penang. Besides,
persisted after taking acetaminophen. There was a possibility
the recruitment of the consumers in this study did not involve
that the consumers were not aware of the maximum daily
those from sundry shop, shopping mall, or supermarket
dose of acetaminophen and subsequently may leads to the
where the consumers may have different acetaminophen
overconsumption of acetaminophen. A previous study by
usage pattern. Hence, the generalizability of the findings is
Hornsby et al. conducted among 284 adults in the United
somewhat limited. In addition, the used of convenient sampling
States showed that 10% of respondents viewed maximum
in the study might possible led to selection bias. Therefore,
dose of acetaminophen as >4 g and 25% were unsure of the
this study is valuable in providing a suggestive baseline data
maximum dose.[27]
on Malaysian consumers’ usage pattern of acetaminophen.
Acetaminophen is generally not recommended to use for A nationwide study involve multicenter and random sampling
asymptomatic mild fever with body temperature <38.5°C.[26] would overcome the limitation of the present study.
As the immunological benefits of fever are decreased at body
temperature of 40.0°C, the use of acetaminophen is needed Conclusions
only when the body temperature is approaching moderate
fever of 40.0°C.[28,29] In fact, previous studies showed that The use of acetaminophen is prevalent among the surveyed
many children can tolerate low‑grade fever up to 39.0°C consumers. The consumers found to have lack of medical advice
and body temperature reduction with antipyretic is not regarding the proper dosage, side effects of acetaminophen,
always necessary.[28,29] Nevertheless, in the present study, and interactions with other agents. The risk of acetaminophen
around 40% of the consumers did not measured their body overdose existed among the consumers. All these issues need
temperature before the used of acetaminophen. Among the to be addressed promptly in order to avoid acetaminophen
consumers who measured their body temperature prior to poisoning among the consumers.
acetaminophen consumption, a high proportion of them Acknowledgment
consumed acetaminophen although they were having The authors would like to thank all the study participants.
low‑grade fever. These findings suggested the need of
education intervention to alert the consumers about the proper Financial support and sponsorship
indication for acetaminophen in the treatment of fever. Nil.
Approximately, one‑third of the respondents did not receive Conflicts of interest
any medical advice regarding acetaminophen consumption. In There are no conflicts of interest.
addition, among those who received medical advice, <10% of
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