Prokaryotic Eukaryotic

Timing Prior to cell division S- Phase

Enzyme DNA protein
Helices Helices
Ss DNA-binding Portions Ss DNA-binding Portions
Primase (an RNA Polymerase) Primase (an RNA Polymerase)
DNA Pol III (Leading/ DNA Pol δ (leading)
Lagging DNA pol α (Lagging)
DNA pol I
DNA Ligase DNA ligase
DNA Gyrase (Topo II) DNA Topoisomerase II
Telomerase
Chapter Summary

DNA Repair
G1 phase of Eukaryotic cell cycle
 UV radiation, Thymine (Pyrimidine), dimers ,excinuclease
 Deaminations (C become U), Uracil Glycosylase
 Loss of purine & pyrimidine ,Ap endonuclease
G2 phase Eukaryotic cell cycle
 Mismatch Repair : hMSH1, hMLH2 (HPNCC)