STAMFORD UNIVERSITY

BANGLADESH

Pharmaceutics - II
Assignment
Course Code: BPH – 320
Topic: Modified Release Drug Delivery System

Submitted To:
Dr. Madhabi Lata
Assistant Professor
Pharmacy Department of
Stamford University

Submitted By:
Noshin Tanjum Nishi
ID: BPH - 066 07402
SECTION: BPH – S - 67
Department of Pharmacy

Date of Submission: 03, May – 2021.

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Index

SL Content Page No.

No.
01 Definition 02

02 Prospects over other dosage forms 02 – 03

03 Classification 03

04 Release Pattern from the formation/ Dosage form 03 – 04

05 Typical types of Modified Release Drug Delivery System 04

06 Advanced Types of Modified Release Drug Delivery System 04

07 Challenges for Modified Release Drug Delivery System 05

08 List of MR Tablets available in Bangladesh 05 – 06

09 Conclusion 06

10 Reference 07
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Definition

Modified release dosage form

A modified-release dosage form is a formulation in which the drug-release characteristics of

time course and/or location are chosen to accomplish therapeutic or convenience objectives not
offered by conventional dosage forms such as solutions, ointments, or promptly dissolving
dosage forms.

Modified release drug products

The term modified release drug product is used to describe product that alter the timing and/or
the rate of release of the drug substance.

Prospect over other dosage forms

Route of Drug Product Examples Comments

Administration
Transdermal drug TTS, Iontophoretic Clonidine Clonidine TTS is
delivery systems Drug delivery transdermal applied every 7 days
therapeutic system to intact skin on the
upper arm or chest.
Small electric
current moves
charged molecules
across the skin.
Ophthalmic Drug Insert Controlled release Elliptically shaped
Delivery System pilocarpine insert designed for
continuous release
of pilocarpine
following placement
in the cul-de-sac of
the eye.
Intravaginal Drug Insert Dinoprostone Hydrogel pouch
Delivery vaginal insert containing
prostaglandin within
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a polyester retrieval
system.
Parenteral Drug Intramuscular drug, Depot injections, Lyophilized
Delivery Subcutaneous drug water immiscible microspheres
products injections (e.g. – oil) containing
controlled release leuprolide acetate
insulin for depot
suspension.
Targeted Delivery IV injection Daunorubicin citrate Liposomal
System liposome injection preparation to
maximize the
selectivity of
daunorubicin for
solid tumors in situ.
Implants Brain tumor, Policeperson 20 with Implant designed to
Intravitreal implant carmustine implant deliver carmustine
directly into the
surgical cavity when
a brain tumor is
resected.

Classification

There are 4 types of Modified release drug. They are –

▪ Sustained release
▪ Extended release
▪ Prolonged release
▪ Delayed release

Release pattern from the formation/dosage form

The release pattern from the formation/ dosage form is given below –

➢ Once the drug starts releasing the drug by zero order kinetics, the concentration the
plasma constant and remains above minimum effective concentration (MEC) but
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below maximum toxic concentration (MTC) for plasma drug concentration v/s time
profile. This will ensure prolonged duration of drug therapy.
➢ Once the drug release starts by zero order kinetic, over the time, the concentration of
drug in plasma starts reducing but it remains above MEC and below MIC.

Typical types of Modified Release Drug Delivery System

The typical types of Modified Release Drug Delivery System (MRDDS) are considered as 3
types. They are –

• Membrane Controlled System – Coated with polymeric

membrane.
• Osmotic Pump Delivery System – Less commonly used types of
modified release system.
• Matrix Controlled System – Formation of mesh like structured
throughout the dosage form.

Advanced types of Modified Release Drug Delivery System

There are 5 advanced types of Modified Release Drug Delivery System. They are –

• Nanotechnology
• Inserts/ Bot system
• Hydrogels
• Multiarticulate Systems
• Bilayer Tablets
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Challenges for Modified Release Drug Delivery System

Challenges for Modified Release Drug Delivery System is given below –

✓ The IV drugs having low water solubility & Low permeability

✓ Drugs cannot be used as modified release system.
✓ Always advised to use solubility enhancers & permeability enhancers in given dosage
form.
✓ Larger Dosage strength should be avoided since increasing the dosage strength the size
of the dosage form.
✓ When polymers are used for forming membrane controller, their concentration will
decide the release rate of drug into blood flow.
✓ It is always advised to used the design of experiment tool to get productive results.
✓ For any dosage form obtaining in vitro in vivo correlations are major concern. The same
case is for modified release systems.
✓ Ideal therapeutic index for API should be greater than 10 to form modified release
systems.

List of MR Tablets available in Bangladesh

The list of Modified Release Tablet available in Bangladesh is given below –

Admira MR – Unimed Unihealth – Gliclazide

Angimet MR – Orion Pharma Ltd. – Trimetazidine Dihydrochloride
Anginox MR – ACME pharma Ltd. – Trimetazidine Dihydrochloride
Angirid MR – General pharma Ltd. – Trimetazidine Dihydrochloride
Angitrim MR – Globe Pharma Ltd. – Trimetazidine Dihydrochloride
Angivas MR – Popular Pharma Ltd. – Trimetazidine Dihydrochloride
Angivent MR – Square Pharma Ltd. – Trimetazidine Dihydrochloride
Antoris MR – Opsonin Pharma Ltd. – Trimetazidine Dihydrochloride
Consucon MR – Incepta Pharma Ltd. – Gliclazide
Cardimet MR – Eskayef Pharma Ltd – Trimetazidine Dihydrochloride
Diamicron MR – Servier Bangladesh Operation – Gliclazide
Diapro MR – Beximco Pharma Ltd. – Gliclazide
Diatrol MR – Pacific Pharma Ltd. – Gliclazide
Dimerol MR – Drug international Ltd. – Gliclazide
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Feelnor MR – Incepta Pharma Ltd. – Trimetazidine Dihydrochloride

Glicid MR – ACME pharma ltd – Gliclazide
Glikazid MR – Eskayef Pharma Ltd – Gliclazide
Glimicron MR – The white horse Pharma – Gliclazide
Glix MR – Navana Pharma Ltd. – Gliclazide
Glizid MR – Opsonin Pharma Ltd. – Gliclazide
Gored MR – General Pharma Ltd. – Gliclazide
Kezid MR – Kemiko Pharma Ltd. – Gliclazide
Metacard MR – Aristo Pharma Ltd. – Trimetazidine Dihydrochloride
Metavas MR – Nipro JMI pharma Ltd. – Trimetazidine Dihydrochloride

After all of this circumstances, we can say that there are only 2 types of drugs are available in
Bangladesh – Gliclazide & Trimetazidine Dihydrochloride.

Conclusion

Though there are many challenges in forming modified release dosage forms but it is definitely
a better choice as part out novel systems for drug delivery. The concept of Modified Release
Formulations emerged with an objective to improve patient’s compliance. Usually this is to
slow the release of the drug and keep steadier levels of the drug in the bloodstream so that the
medicine doesn't have to be taken too often and therefore improves compliance.
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Reference

Applied Biopharmaceutics & Pharmacokinetics by Leon Shargel, Susanna Wu-pong, Andrew

Yu

https://en.wikipedia.org/wiki/Modified-release_dosage

https://accesspharmacy.mhmedical.com/content.aspx?bookid=513&sectionid=41488035

https://www.researchgate.net/publication/317714183_Modified_Release_drug_delivery_syst
ems

https://www.naturalproductsinsider.com/contract-manufacturing/modified-release-delivery-
systems