Nutrition & Biosciences

Pharma Solutions

Avicel® Selection Guide

A versatile excipient addressing your critical formulation needs.
Functionalities tailored to requirements of dosage form, formulation and technology

Nominal
Nominal
Particle
Particle
Nominal Size
Size
zeze
SSi i Particle Size
hh e PH-200 PH-200
PH-200LM
tctc iz PH-200 LM
BBaa ch S
µm µm m
0 0µ

PH-200 PH-200 LM
dd t
20 22000

aasese Ba
ee d
crcr e

Flow
InIn eas

Flow
PH-102
PH-102SCG
SCG
cr
µm µµm m

Flow
PH-102 SCG
In
11550
0

Increase
Increase
0
15

Increase
PH-102
PH-102 SMCC
SMCC90
90 HFE-102
HFE-102 PH-112
PH-112
µm µm m

PH-102 SMCC 90 HFE-102 PH-112

0 000 µ

CE-15
CE-15
110

CE-15
10

PH-101
PH-101 SMCC
SMCC50
50 DG
DG PH-103
PH-103 PH-113
PH-113
PH-302
PH-302
µm µµmm

PH-101 SMCC 50 DG PH-103 PH-113

50 5500

PH-302
SMCC
SMCCHD-90
HD-90
PH-105
PH-105
SMCC HD-90
µm µµm m

PH-301
PH-301 PH-105
cccc
2200

PH-301 g/g/
33
0.0. /cc
20

Decreasing
Decreasing
1.5 11..55%
% %

g
%
%
%

2% 22%
3% 33%
5% 55%

3
0. Moisture
MoistureContent
Content
Decreasing
MT

MT

MT
MT

T
T

NNM

NNM

NNM
NNM

cccc Moisture Content

T

T
T

g/g/
M

M
M

N
N

4 4
0.0. /cc
g
0.
4 Increased
Increasedstability
stabilityof
ofmoisture
moisturesensitive
sensitivedrugs
drugs
Bulk
BulkDensity,
Density, Increased stability of moisture sensitive drugs
Un-tapped
Un-tapped
Bulk Density, NMT
NMT––Not
NotMore
MoreThan
Than
Un-tapped NMT – Not More Than

Co-processed Avicel®
MCC + SiO2

Avicel® MCC MCC + DCP

Direct Compression MCC + Mannitol
Wet Granulation MCC + Guar Gum
 Avicel®
Product Guide

Market Trends and Needs

• Use of direct compression, high-speed tabletting machines
• Implementation of continuous manufacturing
• Need for safe and reliable drug performance
• Formulation flexibility e.g. immediate, controlled, delayed release
• Increasing demand on excipient‘s functionality
• Reliable and simplified supply chain set ups
• Particle engineering and co-processing are attractive tools to meet market needs

With the development of differentiated grades, Avicel® remains an indispensable formulation tool, boosting
productivity and meeting tough formulation challenges. Contact DuPont for assistance with choosing the optimal
Avicel® grade or for help with your tableting formulation issues.

Nutrition & Biosciences

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HO 00019 - 0 E L 02.2020

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