BREAST CANCER

1. Increased susceptibility to breast cancer is most A. p53

likely to be associated with mutation in the B. BRCA-1
following gene : C. Retinoblastoma (Rb)
D. H-Ras
E. BRCA-2

2. A 43 year old lady presents with a 5cm lump in A. T2N0M1

right breast with a 3cm node in the supraclavicular B. T1N0M1
fossa. Which of the following TNM stage it belongs C. T2N3M1
to as per the latest AJCC staging system? D. T2N2M0
E. T3N2M0

3. Risk factors of breast cancer are the following A. Previous history of breast cancer
except : B. Genetic predisposition
C. Estrogen exposure
D. A long menstrual history
E. Pregnancy

4. A girl is having breast carcinoma. Her mother died A. p 53 oncogene

from ovarian carcinoma. You will ask for B. BRCA2 gene
examination of which oncogene? C. Her-2 neu gene
D. C- myc gene
E. BRCA-1

5. Early finding of carcinoma of breast include : A. Skin ulceration

B. Skin retraction
C. Single non-tender, firm to hard mass
ill-defined margins
D. Soft lump with regular border
E. All of the above

6. Sentinel lymph node biopsy is an important part of A. Prostate carcinoma

the management of which of the following B. Breast carcinoma
conditions? C. Lung carinoma
D. Nasopharynx carcinoma
E. Thyroid carcinoma

7. Tamoxifen in the treatment of breast cancer : A. 20 mg per day is as effective as

higher doses
B. Treatment for longer than 5 years has
been proven to be beneficial
C. Is only of benefit in patients with
oestrogen receptor positive tumours
D.10 mg per day is as effective as higher
doses
 E. Is effective in HER 2-NEW positive

8. A female patient, 45years old age, comes with a A. Mastectomy

family history of breast carcinoma. She showed B. Quadrantectomy
microcalcification on mammography. On C. Chemotherapy with CMF regime
biopsy,carcinoma in situ was found. The D. Hormonothyrapy
appropriate management is: E. Lumpectomy

9. Popcorn calcification in mammography is seen in : A. Fat necrosis

B. Fibroadenoma
C. Cystosarcoma phylloides
D. Breast carcinoma
E. All of above

10. Regarding benign breast disease : A. Cyclical mastalgia is the commonest

reason for referral to the breast clinic
B. Fibroadenomas are derived from the
breast lobule
C. Atypical lobular hyperplasia is
associated with an increased risk
of breast cancer
D. Duct ectasia is more common
in smokers
E. All true

11. All true about CA breast, except : A. A long menstrual history

B. Average age 42 years
C. Positive family history is a risk factor
D. Estrogen exposure
E. Pregnancy

12. The increase in risk factor for relapse in stage 1, A. estrogen receptor
carcinoma breast includes all, except : B. High ‘S’ phase
C. Aneuploidy
D. progesterone receptor
E. ↓ Her- 2 neu- oncogene

13. Good prognosis in breast carcinoma with : A. Intraductal carcinoma

B. Colloid carcinoma
C. Lobular carcinoma
D. Ductal carcinoma
E. Ductal carcinoma, and intraductal
carcinoma

14. All are risk factors for CA breast except : A. Multiparity

B. Fibroadenosis
C. Ovarian malignancy
 D. Family history of breast cancer
E. women over age 50

15. Fibroadenomas : A. Can be safely managed

conservatively
B. Most commonly present in late
adolescence or the early 20s
C. Should be diagnosed by triple
assessment
D. At least 30% reduce in size over a 2
year period
E. All true

16. Peau’ d orange in cancer of the breast is indicative A. Tumor growth under the skin
of : B. Infiltration of the Cooper’s ligament
C. Involvement of the dermal and
subdermal lymphatics
D. Low grade secondary infection
E. All of above

17. Most prognostic factor CA breast is : A. Size of tumor

B. Lymph node status
C. Presence of estrogen receptor
D. Age of menopause
E. Age of women

18. Which breast carcinoma is multicentric and A. Ductal

bilateral? B. Lobular
C. Mucoid
D. Colloid
E. Papillary

19. Most common type of breast cancer is : A. Infiltrating ductal

B. Medullary carcinoma
C. Colloid carcinoma
D. Lobular carcinoma
E. Papillary carcinoma

20. Paget’s carcinoma is usually an infiltrating A.Skin of axilla

carcinoma of : B. Lymph-nodes
C. Lungs
D. Breast areola
E. All of above

21. Best chemotherapy regimen for CA breast is : A. Cyclophosphamide, Methotrexate,

5 Fluorouracil
B. Methotrexate, Cisplatin
C. Cisplastin, Adriamycin, Steroid
 D. Methotrexate, Adriamycin, Steroid
E. Methotrexate, Cisplatin, Adriamycin

22. Imaging of pulmonary metastases in breast cancer A. Mammography

is done by : B. Spirography
С. Chest radiography
D. Sputum examination
E. All true
23. M Patient 49 years old ,with breast cancer (tumor 4 A. Stage 1
cm, Movable ipsilateral axillary lymph nodes, B. Stage 11A
No distant metastasis) ,the staging on TNM C. Stage 11B
classification system is : C. Stage 111A
D. Stage 111B

24. The risk factors of breast cancer are : A. Atypical hyperplasia

B. Previous history of breast cancer
C. Estrogen exposure
D. Genetic predisposition
E. All of above
25. Patey’s radical mastectomy removes all the A. Breast
following except : B. Pictoral’s major muscle
B. Lymph nodes under the arm
C. Pictoral’s minor muscle
D. All of above
26. Malignancy of breast is likely to be associated A. Sclerosing adenosis
with : B. Epithelial hyperplasia
B. Duct aplasia
C. Fibrocystic change
D. e) All of above

27. Which the following is important in treatment of A. The tumor’s hormonal status
breast cancer : B. The patient’s age and general health
C. The patient’s menopausal status
D. The presence of known mutations of
breast cancer genes
E. All of above
28. Halsted radical mastectomy removes the : A. Breast
B. Chest muscles
C. All lymph nodes under the arm
D. Fat and skin
E. All of above
29. Most useful technique for the detection of early CA A. Biopsy
breast : B. FNAC
C. Ct scan
D. Chest-X ray
E. Mammography
30. Most common site of CA breast : A. Upper outer quadrant
B. Lower outer quadrant
C. Upper internal quadrant
D. Lower internal quadrant
E. Upper and lower internal quadrant