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Fluconazole
150 mg
Paci c Pharmaceuticals Ltd.
Indications
Fluconazole is indicated for the treatment of vaginal candidiasis, oropharyngeal & esophageal candidiasis and cryptococcal meningitis. It is also e ective for the treatment
of urinary tract infection caused by candida, peritonitis and systemic candida infections (including candidemia, disseminated candidiasis and pneumonia).
Therapeutic Class
Drugs for subcutaneous and mycoses
Pharmacology
Fluconazole is a triazole antifungal agent. It is a potent inhibitor of fungal cytochrome P-450 dependent enzymes. Cytochrome P-450 enzyme system is essential
component of fungal cell membrane which is responsible for the synthesis of ergosterol.
Child (oral):
Doses of 3-6 mg/kg daily have been used. Doses up to 12 mg/kg is recommended.
Intravenous-
Adult: Invasive candidal infections including candidaemia and disseminated candidiasis and cryptococcal infections including meningitis, by IV, 400 mg initially then
200 mg daily, increased if necessary to 400 mg daily, treatment continued according to response (at least 6-8 weeks for cryptococcal meningitis)
Child: 6-12 mg/kg daily (every 72 hours in neonate up to 2 weeks old, every 48 hours in neonate 2-4 weeks old); maximum 400 mg daily. Prevention of relapse of
cryptococcal meningitis, by IV, 100-200 mg daily.
Interaction
Concomitant use of cyclosporin or phenytoin with Fluconazole increases the plasma level of cyclosporin or phenytoin. Concomitant use of Fluconazole & warfarin
prolongs the prothrombin time. Rifampicin level is decreased when used with Fluconazole.
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Contraindications
Fluconazole should not be used in patients with known hypersensitivity to Fluconazole or to related triazole compounds.
Side Effects
Fluconazole is well tolerated. Most common side e ects of using Fluconazole includes nausea, vomiting, abdominal pain, diarrhoea, headache and skin rash.
Storage Conditions
Keep in a dry place away from light and heat. Keep out of the reach of children.
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