EX

SY
M
® OL
XANTALGOSIL C
INCI name : ACEFYLLINE METHYLSILANOL MANNURONATE
CAS number : 162030-43-5

Origin
XANTALGOSIL C® is a silanol obtained by condensation of a silicon derivative on acefylline and
alginic acid. The silicon derivative and acefylline are obtained by synthesis, no derivative of animal
origin is used. Alginic acid is obtained after extraction from brown algae, no derivative of animal origin.
All silanols are endowed with some particular biological activities ; XANTALGOSIL C® has been
specially designed for lipolysis.

Analytical composition Technical characteristics

Monomethylsilanetriol 0.34% limpid to slightly opalescent liquid,
in wich silicon 0.1% colorless to slightly yellow
Acefylline 0.87% pH : around 5.5
Alginic acid 0.1% density, 20° C : around 1.0
Water sq 100% miscible with water at room temperature,
not miscible with concentrated alcohols

Availability
5, 30 or 60 kg drums

Uses

Body contour ( LIPOLYTIC, ANTI-CELLULITE )

Body and face firming
Bags under the eyes / puffy eyes
Body and face moisturization
 BIOLOGICAL ACTIVITIES
cAMP AND LIPOLYSIS CLINICAL TEST : ACTIVITY OF XANTALGOSIL C® ON LIPIDIC OVERLOADS
25 volunteers with different types of cellulite were selected for this study.
Adenylate cyclase
XANTALGOSIL C has a notable lipolytic activity. This
® After twice applications per day during 30 days, the centimeters lost were measured for waist, hips, thighs and knees.
activity is directly linked to silicon content; liberated glycerol The results evaluated on centimeters-loss are summarized in the graphs below :
content increases with silicon content.
Phosphodiesterase
ATP

%
cAMP 5’ AMP After treating adipose tissue with XANTALGOSIL C ® , Results: centimeters lost around the waist Results: centimeters lost around the hips
intracellular cyclic AMP concentration is increased in a

%
significant way. 50 50 -3 cm
The lipolytic activity obtained with XANTALGOSIL C ®, 40 40
-6 cm
Inactive triglyceride lipase Active triglyceride lipase compared with results obtained with phosphodiesterase
inhibitors, can not be only linked to this cAMP increase in 30 30

concentration. Average % of
20 20
cm lost
Triglycerides Free fatty acids Hypothesis of a stimulative action on cAMP is advanced ; it 10 10
can be due to silicon. cm
0 0
Glycerol The lipolytic activity could be the answer to an activation of -2 -4 -8
the membrane system, leading to adenylate cyclase
formation, thus to cAMP synthesis which activates, by a

%
Results: centimeters lost around the thighs Results : centimeters lost around the knees
series of reactions, the hormono-sensitive lipase. 50

%
Blood
40 40

30 30

RESULTS ON XANTALGOSIL C® 20
Average % of 20
Average % of
AND ALGISIUM C® FOR 10 cm lost 10
cm lost
GLYCEROL PRODUCTION SLIMMING ACTIVITY cm cm
0 0
XANTALGOSIL C ® and A LGISIUM C ® have been tested for -2 -4 -7 -1 -2 -4

glycerol production due to their activity on adenylate cyclase,

Reference promoting lipolysis. XANTALGOSIL C® has remarkable effects on :
n Mole of glycerol/g of lipid

5 In vitro study has shown that the lipolytic activity induced by - lipolysis in the adipocytes which confirms the results of the experiment on adipocytes in vitro.
ALGISIUM C XANTALGOSIL C ® was higher than the lipolytic activity of - the trophicity and degeneration of the proteoglycans or acid mucopolysaccharides in elastic
4 ALGISIUM C® and theophylline. fibres and collagen.
XANTALGOSIL C
(60mg/lSi) This slimming activity comes along with the regeneration of the - on tissular permeability and thus the resorption of local oedema.
Theophylline surrounding connective tissue, leading to a better
3 1.8 g/l microcirculation which normalizes cellular exchanges and
improves the skin aspect. EFFECTS OF ACEFYLLINE
2
ON THE LIPOPROTEIN LIPASE
1 LPL (activity) XANTALGOSIL C® is obtained from acefylline. This compound is well
SIMPLIFIED OUTLINE OF LIPOLYSIS MECHANISMS speeds 10-2 DO / minute
1
known to inhibit phosphodiesterases and enhance the cAMP
0 concentration in the cells. Cosmetic application of this pharmacologic
Glycerol production for human 2
y = -1.023x + 0.558 r = 0.759 activity is the cAMP dependent lipolysis. Concerning its activity on fatty
adipose tissue with Xantalgosil C 0.75
CAFFEINE
acids metabolism, acefylline inhibits the lipoprotein lipase (LPL). Inhibition
Mean +/- S.E.M. of LPL by acefylline was studied in vitro. The graph on the left shows the
Adenylate cyclase 0.5 activity level of the lipoprotein lipase depending on the concentration in
XANTIC
BASES
acefylline (XANTALGOSIL C® is obtained from 0.87 % of acefylline).
PDE
0.25
5’ AMP cAMP As other compounds of the same family (caffeine and theophylline
Lipoprotein-lipase derivatives), results show that acefylline inhibits the activity of LPL in a
Fatty Acids Triglyceride lipase 0 dose dependent manner.
0 0.1 0.2 0.3 0.4 0.5

Glycerol acefylline (%)

Triglycerides
Glycerol

ADIPOCYTE
Fatty Acids
EXSYMOL EXSYMOL
 Tolerance study

The product is neither toxic nor irritant.

Tolerance has been studied in vitro by alternative methods on both cell culture and
reconstituted epidermis. Ocular tolerance is evaluated by studying cytotoxicity on cornea
isolated fibroblasts culture. Cutaneous tolerance is evaluated on reconstituted epidermis by
valuation of cells viability after a contact period of 24 hours with the product.

Formulation

XANTALGOSIL C ® is stable for pH included between 3,5 and 6,5. On average, the
recommended concentration is 3 to 6%.

Important remark : XANTALGOSIL C® must not be stored at temperature inferior to 0°C

otherwise an irreversible polymerization might occur.

Existing studies
Technical document
*
Lipolytic activity in vitro : adipocytes
*
Tolerances investigations
*
Activity on lipidic overloads “clinical test”
*
Toxicity Tolerance - alternative methods
A3_0595GB0301B.pdf

EXSYMOL S.A.M. - 4 avenue du Prince Héréditaire Albert - MC 98000 MONACO

Tél. : +377 92 05 66 77 - Fax : +377 92 05 25 02
E-mail : exsymol@exsymol.com - Internet : http://www.exsymol.com