Scribd Logo
Upload

Welcome to Scribd!

  • Classification of Adverse Drug Reactions

    Uploaded by

    Fahad Alkenani
    14 views1 page
    This document classifies adverse drug reactions into six types: 1. Augmented reactions are common, related to the drug's pharmacological action, and dose-dependent. Examples include digoxin toxicity. 2. Bizarre reactions are uncommon, unrelated to the drug's mechanism of action, unpredictable, and often have high mortality. Examples include penicillin hypersensitivity. 3. Chronic reactions are uncommon, dose-related due to cumulative exposure, and time-dependent. An example is suppression of the HPA axis from long-term cortisone use.

    Original Description:

    Original Title

    Classification of adverse drug reactions

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    This document classifies adverse drug reactions into six types: 1. Augmented reactions are common, related to the drug's pharmacological action, and dose-dependent. Examples include digoxin toxicity. 2. Bizarre reactions are uncommon, unrelated to the drug's mechanism of action, unpredictable, and often have high mortality. Examples include penicillin hypersensitivity. 3. Chronic reactions are uncommon, dose-related due to cumulative exposure, and time-dependent. An example is suppression of the HPA axis from long-term cortisone use.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    14 views1 page

    Classification of Adverse Drug Reactions

    Uploaded by

    Fahad Alkenani
    This document classifies adverse drug reactions into six types: 1. Augmented reactions are common, related to the drug's pharmacological action, and dose-dependent. Examples include digoxin toxicity. 2. Bizarre reactions are uncommon, unrelated to the drug's mechanism of action, unpredictable, and often have high mortality. Examples include penicillin hypersensitivity. 3. Chronic reactions are uncommon, dose-related due to cumulative exposure, and time-dependent. An example is suppression of the HPA axis from long-term cortisone use.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 1

    Eslam Fahmy

    https://t.me/splenotes
    00201011922837
    Classification of adverse drug reactions
    Type Features Examples Management
    A Augmented • Common 1- Drugs with narrow TI ✓ Reduce dose or withhold
    • Related to pharmacological action. 2- Toxic effects of drugs:
    • Predictable • Digoxin toxicity
    ✓ Low mortality (↓↓) • Serotonin toxicity with SSRI
    • Dose related • Anticholinergic effects of TCA
    B Bizarre • Uncommon 1- Penicillin hypersensitivity ✓ Withhold and avoid in future
    • Not related to pharmacological action. 2- Idiosyncratic reactions:
    • Unpredictable • Acute porphyria
     High mortality (↑↑) • Malignant hyperthermia
    • Non-dose related • Pseudo allergy
    C Chronic • Uncommon 1- Cortisone for long time cause ✓ Reduce dose or withhold.
    • Dose related → Related to cumulative dose suppression of Hypothalamic pituitary ✓ withdrawal may have to be
    • Time related adrenal axis. prolonged.
    D Delayed • Uncommon 1- Teratogenicity ✓ Intractable
    • Time related 2- Carcinogenesis
    3- Tardive dyskinesia
    E End of use (Withdrawal) • Uncommon 1- Opiate withdrawal syndrome ✓ Reintroduced
    • Occur soon after withdrawal of drug. 2- Beta blocker withdrawal ✓ withdraw slowly
    • Myocardial ischemia)
    F Failure • Common 1- Oral contraceptive failure when taken ✓ Increase dosage
    • Often caused by drug interaction with enzyme inducer drug.

    You might also like