Volume 43, Number 3, March 2021

Editorial
431 Coffee: More Than Just Your Morning Pick-Me-Up
Ravi Jhaveri
GASTROENTEROLOGY UPDATE: NONALCOHOLIC FATTY LIVER DISEASE
Editorial
436 Nonalcoholic Fatty Liver Disease: Epidemiology, Assessments, and Interventions Entering 2021
A. Sidney Barritt
Reviews
438 Advances in the Epidemiology, Diagnosis, and Management of Pediatric Fatty Liver Disease
Anandini Suri, Eric Song, Johan van Nispen, Marcus Voigt, Austin Armstrong, Vidul Murali, and Ajay Jain
455 Noninvasive Evaluation for Nonalcoholic Fatty Liver Disease and Nonalcoholic Steatohepatitis
Shannon Kogachi, and Mazen Noureddin
473 Nonalcoholic Fatty Liver Disease: A Global Perspective
Wei‑Kei Wong, and Wah‑Kheong Chan
500 Therapy for Nonalcoholic Fatty Liver Disease: Current Options and Future Directions
Patrick Campbell, Allison Symonds, and A. Sidney Barritt IV
Commentary
518 The Role of Advanced Practice Providers in the Care of Nonalcoholic Fatty Liver Disease
Andrea Gajos, and Elliot B. Tapper
FEATURED CONTENT
Original Research
526 Express Track: Pharmacokinetics and Safety of Extended-release Ranolazine in Korean and White
Healthy Subjects
Hyounggyoon Yoo, Sang Won Lee, Deok Yong Yoon, Seo Hyun Yoon, Joo‑Youn Cho, Kyung‑Sang Yu, In‑Jin Jang,
and SeungHwan Lee
535 Express Track: Antipsychotic Adherence, Resource Use, and Costs Before and After the Initiation of
Once-monthly Paliperidone Palmitate Therapy Among Medicaid Beneficiaries With Prior Schizophrenia
Relapse
Maryia Zhdanava, Dee Lin, Marie‑Hélène Lafeuille, Isabelle Ghelerter, Laura Morrison, Patrick Lefebvre, and
Kruti Joshi
COVID Commentary
549 The COVID-19 mRNA Vaccines and the Pandemic: Do They Represent the Beginning of the End or
the End of the Beginning?
Ravi Jhaveri

Continued on next page

Table of Contents – continued

COVID Reviews
557 Sex- or Gender-specific Differences in the Clinical Presentation, Outcome, and Treatment of SARS-
CoV-2
Jeannette Wolfe, Basmah Safdar, Tracy E. Madsen, Kinjal N. Sethuraman, Bruce Becker, Marna Rayl Greenberg,
and Alyson J. McGregor
e57 A Critical Appraisal of the Effects of Anesthetics on Immune-system Modulation in Critically Ill Patients
With COVID-19
Athanasios Chalkias, Erin F. Barreto, Eleni Laou, Konstantina Kolonia, Marc H. Scheetz,
Konstantinos Gourgoulianis, Ioannis Pantazopoulos, and Theodoros Xanthos
Original Research
572 Effect of Pegylated Interferon Plus Tenofovir Combination on Higher Hepatitis B Surface Antigen Loss
in Treatment-naive Patients With Hepatitis B e Antigen -positive Chronic Hepatitis B: A Real-world
Experience
Chengguang Hu, Yangda Song, Cuirong Tang, Meng Li, Junwei Liu, Jia Liu, Minjun Liao, Fuyuan Zhou,
Yong‑Yuan Zhang, and Yuanping Zhou
582 Meta-analysis of the Efficacy and Tolerability of Immune Checkpoint Inhibitors Combined With
Chemotherapy in First-line Treatment of Small Cell Lung Cancer
Jiao Wu, Aifen Zhang, Lu Li, Sicheng Liu, Fang Yang, and Runxiang Yang
594 Interindividual Variability in the Pharmacodynamic and Pharmacokinetic Characteristics of
Recombinant Human Insulin and Insulin Aspart
Ting Li, Hui Liu, Hongling Yu, Jingtao Qiao, Lisi Sun, and Yerong Yu
e71 Effect of Probiotic, Prebiotic, and Synbiotic Supplementation on Cardiometabolic and Oxidative Stress
Parameters in Patients With Chronic Kidney Disease: A Systematic Review and Meta-analysis
Mahsa Bakhtiary, Mojgan Morvaridzadeh, Shahram Agah, Mehran Rahimlou, Edward Christopher,
Joshua R. Zadro, and Javad Heshmati
602 Frequency and Patterns of Prescribing Antihypertensive Agents in Outpatient Kidney Transplant
Recipients Among Six Cities in China from 2011 to 2018
Wenjing Hou, Dandan Li, Su Shen, Jun Lin, Anqi Lou, and Aiping Wen
613 Efficacy, Safety, and Tolerability of a Novel Cyclosporine, a Formulation for Dry Eye Disease:
A Multicenter Phase II Clinical Study
Wen‑yan Peng, Rong‑xin Chen, Hong Dai, Lei Zhu, Ying Li, Zi‑qing Gao, Xiao‑yi Li, and Shi‑you Zhou
629 Pharmacokinetic Comparability of Risankizumab Formulations in Prefilled Syringe and Auto-injector for
Subcutaneous Injection
Hoi‑Kei Lon, Ling Cheng, Sai Nudurupati, Ralf Loebbert, Rachel Duan, Jasmina Kalabic, and Yinuo Pang
637 Glycerol Infusion Versus Mannitol for Cerebral Edema: A Systematic Review and Meta-analysis
Jia Wang, Yan Ren, Li‑Juan Zhou, Lian‑Di Kan, Hui Fan, and Hong‑Mei Fang

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