25/05/2021 Natural substances and semisynthetic derivatives as potential alternative products against SARS-CoV-2 - PubMed

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Mini Rev Med Chem. 2021 Feb 3. doi: 10.2174/1389557521666210203154541.

Online ahead of print.

Natural substances and semisynthetic derivatives as

potential alternative products against SARS-CoV-2 FOLLOW NCBI

Virginia Fuochi  1 , Pio Maria Furneri  1

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PMID: 33535950 DOI: 10.2174/1389557521666210203154541

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Abstract
Background and objective: Today, a new β-coronavirus called SARS-CoV-2 has emerged and it is
causing a global pandemic. Inter-human transmission studies have indicated a significant role of
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aerosols in the transmission of many respiratory viruses. Hence, it is very important to decrease the
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spread of the virus through disinfectant agents. This review aimed to provide an overview related to
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possible alternative inhibitory molecules against this virus.
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Method: For this review the literature search was performed in the MEDLINE electronic database
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using the public access known as NCBI-PUBMED. Keywords 'coronavirus' and "SARS-CoV-2" and
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"COVID19" were used. No specific time range was used.
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Results: We provide a review related to structure, anti-coronavirus activity and molecular mechanism
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of natural substances and semisynthetic derivatives such as glycopeptides, lipopeptides, probiotics,
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surfactants, terpenes and resveratrol. We also include the latest in vitro experiments with anti-SARS-
CoV-2 activity. We also provide the theoretical basis for discussing the prospects of such natural NLM NIH HHS USA.gov
molecules as possible alternative anti-Coronavirus products, so as to develop a complete screening
for future applications.

Conclusion: In summary, this review suggest to investigate deeper several molecules most of which
belong to natural substances to fight COVID19 disease.

Keywords: SARS-CoV-2; coronavirus; glycopeptides; polyphenols; probiotics; resveratrol; terpenes.

Copyright© Bentham Science Publishers; For any queries, please email at epub@benthamscience.net.

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https://pubmed.ncbi.nlm.nih.gov/33535950/ 1/1