Eleni Papadopoulou .

et al had done a cohort studyMaternal cell phone use in early pregnancy and
child’s language, communication and motor skills at 3 and 5 years: the Norwegian mother

his prospective study includes 45,389 mother-child pairs, participants of the MoBa, recruited at mid-
pregnancy from 1999 to 2008. Maternal frequency of cell phone use in early pregnancy and child
language, communication and motor skills at 3 and 5 years, were assessed by questionnaires. Logistic
regression was used to estimate the associations. Results

No cell phone use in early pregnancy was reported by 9.8% of women, while 39%, 46.9% and 4.3% of
the women were categorized as low, medium and high cell phone users. Children of cell phone user
mothers had 17% (OR = 0.83, 95% CI: 0.77, 0.89) lower adjusted risk of having low sentence
complexity at 3 years, compared to children of non-users. The risk was 13%, 22% and 29% lower by
low, medium and high maternal cell phone use. Additionally, children of cell phone users had lower
risk of low motor skills score at 3 years, compared to children of non-users, but this association was
not found at 5 years. We found no association between maternal cell phone use and low
communication skills.

Conclusions

We reported a decreased risk of low language and motor skills at three years in relation to prenatal
cell phone use, which might be explained by enhanced maternal-child interaction among cell phone
users. No evidence of adverse neurodevelopmental effects of prenatal cell phone use was reported.

Meta-Analysis

Int J Environ Res Public Health

. 2020 Nov 2;17(21):8079.

 doi: 10.3390/ijerph17218079.

Cellular Phone Use and Risk of Tumors: Systematic Review and Meta-Analysis
Yoon-Jung Choi 1 2 3, Joel M Moskowitz 4, Seung-Kwon Myung 1 5 6, Yi-Ryoung Lee 7, Yun-Chul Hong 2 3 8

Affiliations expand

 PMID: 33147845

 PMCID: PMC7663653

 DOI: 10.3390/ijerph17218079

Free PMC article

Abstract

We investigated whether cellular phone use was associated with increased risk of tumors using a
meta-analysis of case-control studies. PubMed and EMBASE were searched from inception to July
2018. The primary outcome was the risk of tumors by cellular phone use, which was measured by
pooling each odds ratio (OR) and its 95% confidence interval (CI). In a meta-analysis of 46 case-control
studies, compared with never or rarely having used a cellular phone, regular use was not associated
with tumor risk in the random-effects meta-analysis. However, in the subgroup meta-analysis by
research group, there was a statistically significant positive association (harmful effect) in the Hardell
et al. studies (OR, 1.15-95% CI, 1.00 to 1.33- n = 10), a statistically significant negative association
(beneficial effect) in the INTERPHONE-related studies (case-control studies from 13 countries
coordinated by the International Agency for Research on Cancer (IARC); (OR, 0.81-95% CI, 0.75 to 0.89-
n = 9), and no statistically significant association in other research groups' studies. Further, cellular
phone use with cumulative call time more than 1000 h statistically significantly increased the risk of
tumors. This comprehensive meta-analysis of case-control studies found evidence that linked cellular
phone use to increased tumor risk.

J Clin Oncol

. 2009 Nov 20;27(33):5565-72.

 doi: 10.1200/JCO.2008.21.6366. Epub 2009 Oct 13.

Mobile phone use and risk of tumors: a meta-analysis

Seung-Kwon Myung 1, Woong Ju, Diana D McDonnell, Yeon Ji Lee, Gene Kazinets, Chih-Tao Cheng, Joel M

Moskowitz

Affiliations expand

 PMID: 19826127

 DOI: 10.1200/JCO.2008.21.6366

Abstract

Purpose: Case-control studies have reported inconsistent findings regarding the association between
mobile phone use and tumor risk. We investigated these associations using a meta-analysis.

Methods: We searched MEDLINE (PubMed), EMBASE, and the Cochrane Library in August 2008. Two
evaluators independently reviewed and selected articles based on predetermined selection criteria.

Results: Of 465 articles meeting our initial criteria, 23 case-control studies, which involved 37,916
participants (12,344 patient cases and 25,572 controls), were included in the final analyses. Compared
with never or rarely having used a mobile phone, the odds ratio for overall use was 0.98 for malignant
and benign tumors (95% CI, 0.89 to 1.07) in a random-effects meta-analysis of all 23 studies. However, a
significant positive association (harmful effect) was observed in a random-effects meta-analysis of eight
studies using blinding, whereas a significant negative association (protective effect) was observed in a
fixed-effects meta-analysis of 15 studies not using blinding. Mobile phone use of 10 years or longer was
associated with a risk of tumors in 13 studies reporting this association (odds ratio = 1.18; 95% CI, 1.04
to 1.34). Further, these findings were also observed in the subgroup analyses by methodologic quality of
study. Blinding and methodologic quality of study were strongly associated with the research group.

Conclusion: The current study found that there is possible evidence linking mobile phone use to an
increased risk of tumors from a meta-analysis of low-biased case-control studies. Prospective cohort
studies providing a higher level of evidence are needed.