[UNIVERSITY OF SANTO TOMAS — oe FACULTY OF PHARMACY Boi 2/F Main de, Espohe Boulevard, Sampaec, Mania, Philipines 1005 SS Tel Nos: (632) 406-2631 loc 8273/(63-2) 731-4040 / Website: wuwustedu bh FACULTY OF PHARMACY ‘SEMINAR 2 EXAMINATION (A.Y. 2017-2018) CLINICAL CHEMISTRY 2 SPECIAL CLASS. f) 1. A serum sample was assayed for bilirubin for birubin a(Z0ars, nd the result was 12 mad. Te same sample was retested atom. The result now 1,8 mg/ot. The most ikely explanation for this discrepancy i: A. the reagent has deteriorated x C2 caleulation error inthe st assay 'B. the sample was exposed to light” D. the sample was not refrigerated L) 2. Giirbihs transported from reticloendothell cls othe Iver by ! "a abors ~C-Haptoglobin : 8, Blirubin-binding globulin 0. Transferrin + () GQ) inthe liver) bitirubie is converted to: A. urobilinogen C. bilirubin-albumin complex 8. urebiin rin diglucuronidey = - 4. Which enzyme is responsible for the«njugation of blinubin? glucoronide C. Bilirubin oxidase D. Biliverdin reductase C5. (irbins converted inthe fering to which of he oli Te porBRDbinoge ‘come 8. Noglobin D. phospholipid* \Which ofthe following may be associated with dite bilrubin®> A. Soluble in water C. Cennot be excrete in the urine 8. Conjugated with glucuronic acs f\_ 7. inwhich ofthe following disease states is conjugated bilirubin a major serum component? C.neonatal jaundice Nt B hemolysis D.erythroblastosisfetalis se In oe uncon poem unde Depot cross A heart tissue C. liver tissue O. kidney tissue ( 2D) muh fhe faving condos des scene ety of gran transfevae resutin increased untoniugated A \) brubin and keencterusin neonates? A. Glibert disease C. Dubin-Johnson syndrome B. Rotor syndrome 2. Crigler-Najjar syneromer 11, Which condition is cause by deficient secretion a bilirubin into the bile canaliculi? A. Gilbert's disease apr —— {._/ 8 Nenonatal nyperbiirubinemis 0. Criger-Naljar syndrome (2 Which ofthe fain reagent yates corals te components suai ei, ocr ad nd sadam A lafe 8. Zimmerman D. Lowry(7 13, Which reagent is used in the JgGdrassik-Grof method to solubilize unconjugated bilirubin? C ‘8.50% methanal A. Beta-lvceroshsophate 8 Phenylahosphate D. Thymalpnthalein monophosphate C _2-Which a the fllowingcheriea determinations maybe of hel in establishing te presence ofemina id) A. lactate dehydrogenase 8 alanine aminotransferase D. alkaline phosphatase ic acid phosphatase is best for the continuous monitoring method? 28,| Which of the following enzyme substrates for A. phenyl-phosphate 8 thymolphthalein monophosphate _O. beta-glycerophsophate ey \ a P\ @)sonnnesmzaanteas ascent ated in dsenest the | Se tO pile 8. Kidney ‘D. Pancreas x 1) 2 terme escent mcr na gy na ma ee B. Transaminase [) 46 nace panereati a signicant increase in which serum ensyme woud be expected dagnestalh? Rreatneknase SC Akane phosphatase S.Amylase . Aspartate aminotransferase vy) Ose the determination o{amylase, Which assay method is based on the measurement of the quantity of reducing substances formed? — a Amyloclastic €. chromogenic ©. Continuaus: monitoring [)- 25-The most specific encyme test forecute pancreatitsis ‘A. Acid phosphatase =. Amylase 8. Trypsin “Deuipase™ 34, In pesticide poisoning Gholinesterasd Betty i A. increase c.variable “B.Decrease D.No change b _35-Which ofthe following enzymes would not be useful to quantity inthe assessment of liver function?» ‘A. Alanine aminotransferase. Alkaline phosphatase MU? ‘S.Greainekinase ©. Gamma-sutamylransterase G67 C 36-“hich ofthe following sets of tests would be the most useful in giagnosing an AMI? A, AST, D, CK-MB BLD, CK-MB, Troponin 0.10, tyoglabinren an tocando ast wl te ewyes ST, Car became lee in these? G 'A. AST, UD, CK “CCK, AST. LO 8. LO, AST LD, Ck, AST B 38, Which of the following electrolytes is the chief plasma catio whose main function is maintain osmotic pressure? A Chloride x Potassium SS 0. Bicarbonate T 39, Which ofthe following conditions is associated with nfpernatremia? > pq Burns ©. Hypoaldosterenism 0. Oiarchea C Sodium produces which color in a flame? Red Callow” 8. Violet . Magnesium J) |.) ner eect sstianymtes inne ranamson ane mp? > ‘A. Magnesium 5 Phosphorus ©. Sodium [\ 22. a potassium level of 6.8 méa/tis obtained Before reporting the results, the fst step the technologist should take i te €. check the age of the patient B rerun the test D.do nothing, simply report out the result “45, Which of the following cantons is associated with hypokalemia? | K A lson's disease .bigoxi intonation 8. Hemolytic anemia Dealaioss . 45. quan aidaeraniSvesults from a tumor of the adrenal cortex. How would the extracellular fluid be affected? 'A, Normal sodium, decreased potassium levels. B, Decreased sodium, decreased cotassium levels _C. Decreased sodium, increased potassium levels Q) [D. 45. when measuring Gatassiimwith an lorselectve electrode by means of aliquid ion-exchange membrane, what antibiotic wil be incorporated inthe membrane? A. Peniilin C.streptomycin 8. Monactin. (> 36-%o maintain electrical neutrality inthe red bloc cel, ticarbonate leaves the red blood cell and enters the plasma A. Potassium 8 Sodium D. Phosphate ob” ‘The physiologically active form Kcalciun)is D A. Complexed €. Lipid-bound ‘Bitonized? D. Protein-bound ‘A. Decreased blood calcium levels 1PTh 8. Increased renal reabsorption of phosphate C. Decreased bone resorption 6 48, When measuring calcium with the complexometric dye ortho-cresolphthalein complexone, magnesium is kept from interfering by: AA. using an alkaline pH . Measuring at 450 nm _BrAdding &hycronyauinotine™ ©. Compexing to €OTA( sictiereasedanion gag’ at= Nov Can Noe) Lv-teenent] SO. The formation ef iélybdenum elu@complex Is associated with the quantitation of, Calcium C. Magnesium B.sodium ge WNask) ~ coy, QSURABRAARRE eee saecaaD) the 2.Poisoning by methanol - 4. Hypoalbuminemia Cl pho Atand3 ©.4,2,and3 B2ands B.4.2,3,and4 (1 YD) cs wie ormuta is most accurate in presitinglasma osmolliy?> ‘A.Na# 20) *BUN sglucowe B.2(Na) + 2(cI) + glucose + urea “sult C. 2(Na) + (glucose/18} + (BUN/2.8} —_— D.Nae cle kr HCO, sank f\ ee eee - A. Bicarbonate/carbonic acd C. Phosphate/phosphorus acid B Acetatefacetic acd 5, D. Hemoglobin Poy se. wnat iene specimen of hace fr aati of abe durbancesinvohing pulmonary dancin nan ah? ‘A Venous blood © €.capilary Blood era loo D.Urine B Arterial blood ‘ bp. ee Ce tape eter eora €. Sodium fluoride B Heparin b. crate be _— Letstniun eponn SE. To maintain a pH of 7.4in plasma, itis necessary to maintain a ‘A, 10:1 ratio of Bicarbonate to carbonic acid B. 20:1 ratio of bicarbonate to carbonic acid 1:20 ratio of bicarbonate to carbonic acid D. 20:1 ratio of carbonic acid to bicarbonate [) 057. teskationatli concentration may be clase ram the ttl ox and 20; blod lve by wing wich fhe following formulas? {0.03 X (PCO: ~ total C02) €.0103 (total CO: P02) Al B. (total COs + 0.03) x PCO> D. total CO: (0.03 X PCO:) a (2658. siven the flowing information, caleuat te blood pk [ rw Wo= ka + lop | a; e p cra G1 * log Was Dae 24-(00) oN) 0) (O58. Inthe plasma, an excess the concentration oXbicarbonaie without change in PCO: from normal wil resutin what physiological state? A Respiratory acidosis C. Metabolic acidosis B, Respiratory alkalosis D. Metabolic alkalosis ) 060. Which of the folowing isa causecGbeetabaicaKaTGEE> 1. Late stage of salicylate poisoning gaaoy . Renal failure "sy 8. Uncontrolled diabetes malitus™,,., 0. Excessive vomiting ‘A. Hyperventilation C.HCOs reabsorption { |\S4|) Py or 15s produces by the: 7 Hypethalrmus Adrenal cortex 8 Pituitary sland o-Thyroie Cle se ‘The major cetrie’ protein of the thyroid hormone in the blood is: 7 Albumin €. Thyroxine-bnding globulin 8. Beta-micrglobulin ©. Thyroglobulin ete eae ey 2? f —— t || jes je satents wits parary hypothyroih, TSH eves wil key be and wl be tikely ee Decrensed, Normal \ B. Increased, Decreased D. Increased, Normal h : stout { \dfe} ones th develo svt phy TH eve wily be and 74 will kely be A eseesmd nreased C becreased, Normal B. Increased, Decreased D. Increased, Normal By pace presence ot avery high er or anthyoglbulnantbodes andthe detection of anthyrol peroxidase anibsies isMighty suggestive of what disorder? ‘A Multnodular goiter Grave's disease “out B Hashimoto's hyoidts “tw, Thyroid adenoma One _—— fw Gihich ofthe following is he majar mineralacorticoig?2— ‘A. Alosterone,} Shin . androgens 2 copttel penne B. sineprieg A hovered (B® ich of ello statements regardiiadena corel dysfunctions true? i Patients with Cushing's smarome asualiRaveRyertalemia fT B. Cushing's syndrome is associated with glucose intolerance C.addiso's dsease s associated with WEermatremia NO < D Adelson's seat Is caused by clevted levels oferta eG Beatin: 7 § Mdottemne (Coy C Co tists usa to aitngush Cushing's disease (puitry Cushing's) from Cushing's syndrome cused by areal tumor? Low-dose overnight dexamethasone suprelion €.Serum ACTH 7 8, Petrosal sinus sampling ©. Twenty-four-hour urinary free cortisolCorrie divenal hanes pax a screening test for Cushing;s syndrome. The physician wishes to see whether a patient exhibits normal diurnal DO nythm in his or her cortisol secretion, At what time should the specimens be drawn for plasma corisel determination? A.6 am, 29m 22 noon, 6am 8.8m, 4pm 9.12 noonm 12 midnight \) crs. wnien of the folowing condtions is coracterzed 67 primanyhyperalosteraria cause hy gerenal adenoma carcinoma, orhyperslasia? Ls ase "A. Cushing's syndrome .Conn’s syndrome Tadorerae, *39,4% 8 Addison's disease D. Pheochromocytoma DowrSinen ‘assay using 24-hour urine is considered the best single screening test for pheochromocytoma? A, Total urinary catecholamines Homovanilc acid ‘err in obit made 8 vMA D. Metanephrines f\ | |) 7% Seeasregzans? te om feratennessuetin ne sme A stradil-oemetai Gees ne eareeeee B. Estria D. Pregnanediol [IA fe) omen ote folowing nemones soon ccesed by operon 2K inthe serum fprepantwomen who have 2 ets th Down sade? *¥c, 4 wae 8 sr line eto Progesterone Shuman chooniegoaastenn—9-esveda Ast. which set fresuts smost ely inn cma th rina tesla fare? er A, Increased LH, FSH, and decreased testosterone 7 am B. Decreased LH, FSH, and testosterone Achat end pride . Decreased testosterone, androstenedione, and FSH D. Increased androstenedione, decreased testosterone, and normal FSH A Vitamin Niacin 8. Vitamin ¢ D. Thiarming p 82. Beriberi is associated with deficiency of vitamin: 1) YBa. Geum associate with diene of wich af the folowing vitamins? Jf A itamin enacn B vtamin b.Tamine [fet nicked is asoeated with decency of which ofthe folowing vitamins? *vtomint, noc b.vtamine itarind ~ Pas Getag is ssateu with detseney of veh ofthe flowing wan? 2 vtorind Thiamine 2 vierin 0 Nac f [P)86. Clinical assays for tumor markers are most important for: . } ‘A screening fr the presence of cancer C. confirming the absence of a disease 8, monitoring the course of a known cancer 0. identifying patients at risk for cancer \v b| {). er. oetetin otwhich fhe folowing substances ismost seul to monitor the course of patient wt Gaul anes? ‘A alpha-fetoprotein x C. prolactin B, carcinoembryonic antigen D. testosterone A Ag8 ‘feos concentrations of aiptfetapsctein AF) in alts are mast caractricaly asso with ‘A hepatoceluiar carcinoma . chronic ative hepatitis B. alcoholic cirrhosis = D, multiple myelomai] 0° cxreoanerosefelase Facet Bed ee preduced ws malgnaney renga i) y A. brain ¢.bone A 3B. testes D. colon _Butestes (JD 20. cancer antigen 125 (CA 125) is a tumor marker associated with: breast carcinoma ~ C.lung cancer 8. colon cancer D. ovarian and endometrial carcinoma h lex Which ofthe following tumor markers is used is used to monitor persons with br@st cancer recurrence of eisease? J cathepsin ccaiss — — 8B. Retinoblastoma gene D. Estrogen receptor (ER) Ppo2. resent fo dana baie eps ad ety v ‘A. Gas chromatography CThin-layer chromatography seater ronatgcny 0. cuechanstoepyiascecamety + [ e€ani tnerapy wide inthe restment of A, Hypertension Aggression 8 Hyperactivity D. Manie-depression (C D)2*Cbizenn procainamide afd auiisine are crus that may be classifies as: ‘A Aminoglycosides= C. Acetaminophen B. Antidepressants D. Cardioactive -¢ Itis used for treatment of petit mal and absence seizure: 4, Phenobarbital ———C Valproie acid 8B. Carbamazepine D. Ethosuximides {A drug that relaxes the smaoth muscles of the bronchial passage is: Gorshine the major metabolite of: ny The most serious effect of ethanol ingestidn is: ‘A. Hallucinations . Psychosis: B. Blindness D. Liver damage — IA 100. Because of its antitussive and analgesic properties, it is one of the most frequently prescribed opiates ih the ) in world. ~ A.Codeine “under opiate . Morphine 8. Heroin ©. OxycodoneSEMINAR 2 ENR ees caustics Cot eee aes ceed anes TOPICS ayes > Electrolytes and Osmolality Acid-Base BalancelDisordors [> "Acla-Base BalancelDisor > Endocrinology _ | 10 > Toxicology and Therapeutic Drugs "Tumor Markers, 5 viyly Cag Sipe ney errs Fe Peinsbaaih ra pee a ec a aT tee aT tomer ae Prepared by: Bren paper cei enn Noted by: NY . assoc. Prof Edilbprto P. Manahan, PhD Chair, Department of Medical Technology Approved by: Prof. Aleth Therese L. Dacanay, PhD Dean, Faculty of Pharmacy