2nd Sessional Q.

Which of the following is used in the treatment of myasthenia gravis?

(a) Pyridostigmine (b) Neostigmine
(c) Both (d) None

Which of following is hydrophilic organophosphate compound?

(a) Parathion (b) Malathion
(c) Ecothiophate (d) None

The basic ring present in pilocarpine is:

(a) Tetrahydrofuran and Indole
(b) Tetrahydofuran and Imidazole
(c) Tetrahydrofuran and Pyrole
(d) None

One of the following is a selective COX-2 inhibitor _________

(a) Paracetamol (b) Nimesulide
(c) Valdecoxib (d) None

The isoxazole ring is present in which of following drug?

(a) Valdecoxib and paracoxib
(b) Celecoxib and rofecoxib
(c) Celecoxib and valdecoxib
(d) Paracoxib and celecoxib

Basic ring present in valdecoxib is _________

(a) Pyrazole (b) Furan
(c) Isoxazole (d) None

Toxic metabolite of paracetamol which causes hepatotoxicity is

(a) N-acetyl p-benzoquinone imine
(b) N-acetyl p-benzoquinone amine
(c) O-dealkyl acetaminophen
(d) None

Metabolism of paracetamol occurs by

(a) Glucuronide and glycine
(b) Glucuronide and sulphate
(c) Glutathione and sulphate
(d) Glutathione and sulphate

Which isomer of ibuprofen is more active?

(a) S (–) isomer (b) R (–) isomer
(c) S (+) isomer (d) R (+) isomer

Starting material for ibuprofen is

(a) Isobutyl benzene
(b) Isopropyl benzene
(c) Isobutyl acetophenone
(d) None

Phenylbutazone is a _________

(a) Pyrazolone derivative

(b) Pyrazolidinedione derivative.
(c) N-arylanthranilic acid derivative
(d) None of the above

Which of following bound 99% to protein?

(a) Ibuprofen (b) Flubiprofen
(c) Naproxen (d) All
Clozapine is
(a) Dibenzoxazepine derivative and D-2 blocker
(b) Dibenzoxazepine derivative and D-4 and 5HT-2a blocker

(c) Dibenzazepine derivative and D-4 and 5HT-2a blocker

(d) Dibenzazepine derivative and D-2 and 5HT-2a Blocker

Which of the following butyrophenones contains benzimidazolinone side chain?

(a) Haloperidol (b) Droperidol
(c) Penfluridol (d) Trifluperidol

Metabolism of phenacetin occurs by

(a) N-dealkylation (b) O-dealkylation
(c) Hydroxylation (d) None of above

Which of following drugs gives oil of wintergreen during urinary excretion?

(a) Aspirin (b) Salicylamide
(c) Methyl salicylate (d) All of above

Barbiturates are
(a) Derived from malonic acid
(b) Cyclic ureides
(c) Urea derivatives
(d) All of the above

Phenobarbital is classified as a
(a) Short-acting barbiturate
(b) Long acting-barbiturate
(c) Intermediate acting barbiturate
(d) Ultra-short-acting barbiturate

Sedative action of barbiturate is due to substituent at C-5. It is due to

(a) High lipophilicity of group at C-5 position
(b) Electronic withdrawing effect
(c) Sterric effect
(d) Low lipophilicity of group at C-5position

Morphine undergoes microsomal oxidation by

(a) N-dealkylation
(b) Aromatic hydroxylation
(c) Oxidative deamination
(d) O-dealkylation

IUPAC name of diclofenoac is

(a) Sodium 2-[(2,6-dichlorophenyl} amino] phenyl acetate
(b) Sodium 2-[(2-chlorophenyl) amino] phenyl acetate
(c) Sodium 3-[(2,6-Dichlorophenyl) amino] phenyl acetate
(d) Sodium 2-[(6-chlorophenyl} amino] phenyl acetate

Paracetamol undergoes metabolism by

(a) N-hydroxylation (b) Deamination
(c) O-dealkylation (d) Oxidative deamination

Risperidone belongs to class of

(a) Benzisoxazole (b) Butyrophenone
(c) Benzimidazole (d) DihydroindoJone

One of the following is false about SAR of benzodiazepines. Identify.

(a) Alkyl substituents at 3-position decreases the activity
(b) N-substituent at 1-position should be small
(c) A phenyl or pyridyl at 5-position decreases the activity
(d) The presence of electron-attracting substituent at position 7 is required for activity

Morphine and heroine differ from each other by

(a) Methyl group on nitrogen
(b) Acyl group at C3 and C6
(c) Absence of d ring
(d) Acyl group at C4 and C6

Starting material for synthesise of mefenamic acid is

a. 2-Chloro benzoic acid and 2,3-dimethyl benzamine
b. 4-Chloro benzoic acid and 2,3-dimethyl benzamine
c. 2-Chloro benzoic acid and 2,2-dimethyl benzamine
d. 4-Chloro benzoic acid and 2,2-dimethyl benzamine

Which of the following point about SAR of morphine is incorrect?

e. An aromatic phenyl ring is essential for activity.
f. Modification on phenolic hydroxyl group decreases the activity.
g. Any other substitution on phenyl ring diminishes activity.
h. None

Starting material for synthesis of ketamine is

a. 2-chloro benzonitrile and cyclo pentyl magnesium bromide
b. 3-chloro benzonitrile and cyclo hexyl magnesium bromide
c. 2-chloro benzonitrile and cyclo hexyl magnesium bromide
d. None

True/False:
Anticholinergic drugs should not be administered to patients with Glaucoma- True

Replacement of the -NH group at position 1 of the hydantoin system with an oxygen atom yields the
oxazolidine-2,4-dione system- True

NSAID’s has more abusability than morphine and other narcotic drugs- False

Removal of 3,4 epoxide bridge in morphine structure result in the compound that is referred to as
morphinans- True

Substitution of halogen atom on aromatic ring of salicylates decreases potency and activity & also
toxicity- False

Mefenamic acid is effective in dysmenorrhea- True

Levo isomer of antipsychotic drugs are less active than dextro- False

aromatic system substituted with fluoro group at para position enhances antipsychotic activity- True
2-Nitro benzyl chloride is starting material for synthesis of Carbamazepine- True

2-PAM is cholinesterase reactivator- True