MEBO Scar Ointment

Weiwei Xu
 What is MEBO Scar Ointment?

MEBO Scar Ointment has been widely used for

preventing scar formation and improving scar appearance.

MEBO Scar Ointment could provide a moist environment and

necessary nutrients, inhibit fibroblast hyper-proliferation, regulate
collagen ratio and arrangement, control blood flow, therefore
restore skin’s physiological structure and function.
SCAR OVERVIEW
 Incidence

Each year in the developed world 100 million patients acquire scars, some of which cause
considerable problems, as a result of 55 million elective operations and 25 million
operations after trauma.

11 million keloid scars and 4 million burn scars, 70% of which occur in children.
Oleum Sesami Cere Flava
Sesame Oil Beeswax
Physical, aesthetic, psychological, and social consequences that may be associated with
substantial emotional and financial costs.

A Bayat, D A McGrouther, and M W J Ferguson. Skin scarring. BMJ. 2003 Jan 11; 326(7380): 88–92.
Causes

Accident
Surgery
Burn and scald
Bite and scratch
Skin condition, such as chickenpox or acne
Oleum Sesami Cere Flava
Pregnancy and overweight
Sesame Oil
Injection, such as vaccination against tuberculosis (BCG vaccination) Beeswax

↑ Risk of keloid and hypertrophic scar: family history, 10-30 years old.
↑ Risk of keloid: darker skin.
Impact

Physical Impact Psychosocial Impact

• Itching • Depression
• Pain • Anxiety
• Deformity • Sleep disturbance
Cere Flava
• Abnormal skin function • Loss of self esteem
Beeswax
How do scars form?

When dermis is damaged, our body forms new collagen fibers to

mend the damage, resulting in a scar. Scar tissue has same collagen
as normal tissue but has a different texture and quality.

Oleum Sesami

For 3 months or longer, new collagen continues to form,

Sesame Oil and blood Beeswax
supply increases, causing scar to become raised, lumpy and red.
Some collagen then breaks down, and blood supply reduces, scar
gradually becomes smoother, softer and paler. Although scars are
permanent, they can fade over a period of up 2 years.

Basket weave (Normal) → Single Direction (Scar)

How do scars form?

Oleum Sesami

Sesame Oil

Hemostasis Phase Proliferation Phase Remodeling Phase

Fibroblasts are Fibroblasts are activated in Extracellular matrix (ECM)

recruited to the wound. the wound and begin to is remodeled by proteases
synthetize collagen. and other enzymes.
 Types

Hypertrophic scar Keloid Contracture Scar Atrophic Scar Stretch Marks

Red, raised scar Grow beyond Skin shrinks and Indented appearance. Skin stretches or
forming along the boundary of tightens. Commonly Commonly associated shrinks quickly,
wound. Grow original wound. associated with with chickenpox or which causes
within boundary of burns. acne. collagen and elastin
original wound. to rupture.
Treatment

Topical Medication Steroid Injection

Compression Therapy Cryotherapy

Radiotherapy Laser

Surgery Combination
INGREDIENTS
Ingredients

Opuntia Milpa Alta Oleum Sesami Cere Flava

Cactus Extract Sesame Oil Beeswax

• Inhibit typeⅠcollagen • Inhibit fibroblast hyperproliferation • Anti-itch

• Increase type Ⅲ collagen • Promote collagen rearrangement
• Anti-inflammatory • Anti-inflammatory
• Analgesic • Analgesic
INDICANTIONS
Indications

✓ Traumatic Scar
✓ Surgical Scar
Various Causes of Scars
✓ Burn and Scald Scar
✓ Scars caused by Skin Problems

✓ Hypertrophic Scar
✓ Atrophic Scar
✓ Keloid Various Types of Scars
✓ Contracture Scar
✓ Stretch Marks
CLINICAL EFFICACY
 Efficacy

Treating burn scars*.

*Study enrolled 316 patients with deep II degree burn.

Li C-J, Wu S-J, Hu J-W, Li J. Clinical application and efficacy assessment of MEBO Scar Ointment. The Chinese Journal of Burns Wounds & Surface Ulcers. 2002;14 (3):158-160
 Efficacy

Treating scars caused by burn and scald, trauma and ulcer*.

Number of Patients
30

25

20

15
Total effective Rate
10 69.8% (3 months) vs. 86.8% (6 months)

0
3 Months 6 Months
Highly Effective Effective Ineffective

*Study enrolled 53 patient with hypertrophic scars, and treated with ultrasonic introduction of MEBO combined with
elastic compression therapy. Highly effective/Effective/Ineffective: Scar score reduction ratio ＞75%/ 50-75%/＜50%

Bu P-Y, Luo C-Q, He Q-Y, Wu X-X, Yang P. Clinical efficacy of ultrasonic introduction of Scar Ointment combined with elastic compression therapy in treating hypertrophic scar. The Chinese Journal of Burns Wounds & Surface Ulcers. 2018;30(4):280-289.
 Efficacy

Treating post-operative scars*.

Scar Quality at 120 days

MEBO (%) Saline (%)

Efficacy at 120 days
Itching
80%
Relieved 97.6 2.0
70%
Not 2.5 98.0
60% Texture

50% Normal 50.0 2.0

Soft 47.5 50.0
40%
Hard 2.5 48.0
30%
Scar Dystrophy
20% Shrinkage 97.5 2.0
10% Slight shrinkage - 74

0% Hypertrophic scar 2.5 24.0

Highly Effective Moderately Effective Slightly Effective Ineffective Skin Color
MEBO Saline Close to Normal 75.0 2.0
Light in Color 22.5 50.0
*Study enrolled 90 patients undergoing various elective surgeries. Dark pink 2.5 48.0

Mustafa Usama. The use of MEBO Scar Ointment in the treatment and prevention of post-operative wound scars. International Journal of Pharma Research and Health Sciences. 2016, Vol 4 (s), 1171-1178.
MECHANISM OF ACTION
Scar Tissue Feature
 Mechanism

Enhance Skin Hydration

Higher hyaluronic acid intensity in MEBO group indicates higher skin hydration.

Basson R, Baguneid M, Foden P. Functional testing of a skin topical formulation in vivo: Objective and quantitative evaluation in human skin scarring using a double-blind volunteer study with sequential punch biopsies. Adv Wound Care. 2019;8(5):208-219.
 Mechanism

Regulate Intensity and Ratio of Collagens

Collagen Ⅰ (brown staining) with an even distribution

At week 16, MEBO Group’s typeⅠand Ⅲ collagen intensity and ratio Collagen Ⅲ (light brown staining) with an uneven distribution
was similar to normal skin.

Basson R, Baguneid M, Foden P. Functional testing of a skin topical formulation in vivo: Objective and quantitative evaluation in human skin scarring using a double-blind volunteer study with sequential punch biopsies. Adv Wound Care. 2019;8(5):208-219.
 Mechanism

Increase Skin Elasticity

Higher elastin intensity in MEBO group indicates better skin elasticity.

Basson R, Baguneid M, Foden P. Functional testing of a skin topical formulation in vivo: Objective and quantitative evaluation in human skin scarring using a double-blind volunteer study with sequential punch biopsies. Adv Wound Care. 2019;8(5):208-219.
 Mechanism

Control Blood Flow

Blood flow gradually decreased after week 2 in MEBO Group. Reduced blood
flow could reduce fibroblasts’ ability to synthesize collagens.

Basson R, Baguneid M, Foden P. Functional testing of a skin topical formulation in vivo: Objective and quantitative evaluation in human skin scarring using a double-blind volunteer study with sequential punch biopsies. Adv Wound Care. 2019;8(5):208-219.
 Mechanism

Relieve Pain and Itching

*MEBO Group：Ultrasonic introduction of MEBO combined with elastic compression therapy.

Bu P-Y, Luo C-Q, He Q-Y, Wu X-X, Yang P. Clinical efficacy of ultrasonic introduction of Scar Ointment combined with elastic compression therapy in treating hypertrophic scar. The Chinese Journal of Burns Wounds & Surface Ulcers. 2018;30(4):280-289.
DIRECTION FOR USE
Direction for Use
CLINICAL CASES
Cases

Hypertrophic Scar
Cases

Atrophic Scar
Cases

Hyperpigmentation
Cases

Keloid

Before Treatment Scar Excision Apply MEBO for 1 Month Follow-up