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Article in South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde · January 2012
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Vernon J Louw
University of the Free State and Panorama Mediclinic
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The spectrum of sickle cell disease (SCD) encompasses a heterogeneous Post a
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group of disorders that include: i) Homozygous SCD (HbSS), also
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referred to as sickle cell anaemia, ii) Heterozygous SCD (HbAS), also (Login required)
Contact referred to as sickle cell trait, and iii) Compound heterozygous states
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such as HbSC disease, HbSß thalassaemia, etc. Homozygous or article
compound heterozygous SCD patients manifest with clinical disease of
EDITOR varying severity that is influenced by biological and environmental Select Language
Professor factors, whereas subjects with sickle cell trait are largely asymptomatic. Powered by
Janet
Seggie SCD is characterized by vaso-occlusive episodes that result in tissue
ischaemia and pain in the affected region. Repeated infarctive episodes
cause organ damage and may eventually lead to organ failure.
Impact
factor: 1.702
For effective management, regular follow up is necessary, with support
Five-year: from a multidisciplinary health care team. The chronic nature of the
1.845 disease, the steady increase in patient numbers, as well as relapsing
acute episodes have cost implications that are likely to impact on the
provincial and national health budgets. Limited resources mandate the
need for local management protocols for consistency and
standardisation purposes, and which could also facilitate sharing of
HEALTH & resources between centres for maximal utility.
MEDICAL This set of guidelines has been developed for the South African setting,
PUBLISHING
GROUP with the intention of it being regularly updated, to meet new demands CURRENT
and challenges. ISSUE
July 2014
Vol. 104 No. 7
Authors' affiliations
SOUTH PO PU LA R
Nazeer Ahmed Alli, Department of molecular medicine and
AFRICAN A RTI CL ES
MEDICAL haematology, National Health Laboratory Service and School of
ASSOCIATION Pathology, University of Witwatersrand » Tuberculosis
Events | Careers | preventive
CPD Moosa Patel, Clinical haematology unit, Chris Hani Baragwanath hospital therapy: An
and academic head of clinical haematology, department of medicine, underutilised
faculty of health sciences, University of the Witwatersrand strategy to
Hassan Dawood Alli, Department of opthalmology, St John’s Eye reduce
Hospital, Soweto individual risk
of TB and
Fatima Bassa, Division of clinical haematology, Department of Medicine, contribute to
Tygerberg Academic Hospital TB control
Marius J Coetzee, Department of haematology & cell biology, NHLS
Universitas Tertiary Laboratories, University of the Free State » Side-effects
of systemic
Alan Davidson, Department of paediatric haematology-oncology, Red therapy for
Cross Children’s Hospital and University of Cape Town. the
Mohammed Rafique Essop, Department of cardiology, Chris Hani management
Baragwanath Hospital. of breast
cancer
http://www.samj.org.za/index.php/samj/article/view/8470 2014/07/02
Management of sickle cell disease: South African guidelines | Alli | South African Me... Page 2 of 3
The South African Medical Journal | Online ISSN: 2078-5135 | Print ISSN: 0256-9574 | ©
2014 Health & Medical Publishing Group
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http://www.samj.org.za/index.php/samj/article/view/8470 2014/07/02
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