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Received: 26 November 2019 Revised: 18 May 2020 Accepted: 19 May 2020

DOI: 10.1111/jerd.12606

REVIEW ARTICLE

Evaluation of influence factors on the width, length, and width


to length ratio of the maxillary central incisor: A systematic
review and meta-analysis

Yingying Wang BDS1,2† | Yingshuang Song BDS1,2† | Qi Zhong BDS1,2 |


1,2
Chun Xu DDS, PhD

1
Department of Prosthodontics, Shanghai
Ninth People's Hospital, College of Abstract
Stomatology, Shanghai Jiao Tong University Objectives: The aim of this study was to analyze whether symmetry of left and right
School of Medicine, Shanghai, China
2 sides, gender, measuring method, and ethnicity have influences on width (W), length
Shanghai Key Laboratory of Stomatology &
Shanghai Research Institute of Stomatology , (L), and width to length ratio (W/L) of the maxillary central incisor (MCI) and provide a
Shanghai, China
reference for dental treatment planning in the esthetic zone.
Correspondence Materials and Methods: An electronic search was conduct of the dental literature.
Chun Xu, Department of Prosthodontics,
Studies reporting data about measurements were included. Data were extracted and
Shanghai Ninth People's Hospital, College of
Stomatology, Shanghai Jiao Tong University analyzed for the differences between left and right, male and female, different mea-
School of Medicine, Shanghai, China.
suring methods, and ethnicities by Review Manager and Stata statistical software.
Email: imxuchun@163.com
Results: Seventeen studies were included. There were no differences between mea-
surement of the left and right groups, perceived and actual measuring groups. How-
ever, differences were found between genders in MCI's W and L but no difference in
W/L. Differences were also found between Asians and Caucasian subjects in MCI's
W, L, and W/L.
Conclusions: The results of this meta-analysis suggest that symmetry of left and right
sides and measuring method do not influence MCI dimension. Gender and ethnicity
are found as influence factors for MCI dimension. We believe these findings can be
helpful for dentists to decide and design the dimensions of the restorations for maxil-
lary anterior teeth in clinical practices.
Clinical significance
1 In the process of designing maxillary anterior teeth for implantation, the contralat-
eral MCI can be helpful to create a symmetrical esthetic restoration. For patients
with maxillary anterior tooth loss or diastemas, dentists should divide the left and
right space equally and keep the MCI contact area aligned with the midline.
2 Dentists should take face size and gender into consideration when making treat-
ment plans for the MCI. Facial parameters as well as the size ratios of the previous
teeth can be evaluated and may influence the size and shape of the teeth.
3 When measuring anterior teeth or facial dimensions for esthetic evaluation, the
recommended method is to measure the perceived sizes of a facial view image


These authors contributed equally to this work.

This work was supported by Shanghai Municipal Health Commission (grant number 201940009).

J Esthet Restor Dent. 2020;1–13. wileyonlinelibrary.com/journal/jerd © 2020 Wiley Periodicals LLC 1


2 WANG ET AL.

created by a digital camera. Slight discrepancies may exist between the actual and
measured values due to the curvature of the arch and the angle in which the pho-
tograph was taken.

KEYWORDS

ethnicity, gender, maxillary central incisor (MCI), measuring method, symmetry, width/length
ratio

1 | I N T RO DU CT I O N between male and female on the MCI dimension,9,10 and only a few
reported opposite results.2
1
It was reported by Shaw et al. that the social attractiveness of young Two different methods were employed to calculate the dimen-
adults could be influenced by their dental-facial appearance. Today, more sions of MCI. Direct measurements on the teeth with a caliper were
and more patients seek dental treatments to solve their concerns about used in some studies.11 Others used an indirect technique in which
dental appearance. In the practice of esthetic dentistry, it is common to the dimensions were measured on the photograph and then
see patients with multiple missing anterior teeth or tooth defects. It is converted mathematically to the 2D frontal image size of the mouth
very important to decide the dimensions of the restorations for these or cast.12 If measuring directly, there were potential sources of mea-
anterior teeth, especially the maxillary central incisor (MCI), for a success- surement error as reported by Farkas et al.13 such as improper identi-
ful esthetic treatment. A precise knowledge of the esthetics of natural fication of landmarks and problems with measuring instruments. If
anterior teeth is necessary for dental treatments in the esthetic zone. indirectly measuring photographs, slight discrepancies may exist
Dental esthetics were assessed by viewing patients from the front between the actual and measured values due to curvature of the arch
in specific dynamic states like during conversation, with certain facial and the angle in which the photograph was taken.2 However, errors
2
expressions and while smiling. A checklist for dental esthetic restor- from the quality of the impression or cast or of the materials and
ative success was firstly presented by Belser et al.3,4 in 1979 and mixing protocol were also reported.14-16 In this article, the measuring
updated by Magne et al.5 in 2003. This checklist encompassed objec- methods for the MCI size were divided into two groups, perceived
tive and subjective parameters, and the appearance of anterior teeth MCI size and actual MCI size, no matter whether they were measured
was considered as an important objective criterion within the esthetic directly or indirectly (Figure 1). The perceived group meant MCI was
checklist.4 MCI was most dominant in anterior teeth when smiling.2 As observed in front of patients including measuring front photographs
for the subjective esthetic standard, different people have different and frontal projection of casts.17,18 The actual group meant measuring
2
evaluation indicators. It was reported by Ku et al. that the natural MCI's physiological dimensions including directly measuring teeth on
observed MCI size was often different from the esthetic MCI size that patients or casts with a caliper.19 In this article, the difference
people prefer. Therefore, in this article, we chose to study the objective between these two measuring methods was analyzed to determine
esthetic standard of MCI to help in clinical treatment. Studying the nat- which method is more predictable and accurate for the measuring of
ural MCI size is a reliable and direct way for this aim. the MCI size.
A number of articles have reported factors influencing the MCI's Ethnicity was also considered as a potential influence factor on
dimension, including symmetry of left and right sides, gender, measur- the dimension of MCI. However, only a few studies compared the
ing method, and ethnicity; but, different articles conveyed different MCI dimensions of different ethnicities, and these results were not
opinions about how these factors influenced the MCI's dimension. In uniform.20,21
the present article, these previous studies were systematically Various investigations about MCI size have been done. However,
reviewed, and a meta-analysis was conducted by pooling the data of most related studies were limited by an unequal distribution of
these individual studies together, to get a more specific conclusion genders,14 and some poorly stated inclusion and exclusion criteria
about the factors influencing the MCI's dimension. resulting in discounting the effect of some important factors to MCI
One potential factor which could influence MCI dimension was measurements such as incisor's wear and gingival alteration on crown
the symmetry of MCI at the left side and the right side. Some authors height measurements.5,22 The majority of the studies were of the
reported discrepancies of the dimensions of right and left MCI in hori- Caucasian population. Whether the data complied with Asians or not
6
zontal and vertical measurements, whereas others found no signifi- was unknown. A more comprehensive analysis which took these
cant differences.7,8 abovementioned factors into consideration should be done.
Another factor is gender, which is usually thought to be a major The null hypothesis was there would be no differences in these
potential influence factor on the dimension of MCI. There were many studies between right and left side, between male and female,
gender-related papers. Most of them reported significant difference between the two measuring methods, and between Asian and
WANG ET AL. 3

FIGURE 1 Measurement of the width, length, and width to length ratio of maxillary central incisor

Caucasians subject on the width (W), length (L), and width to length synthesis were further reduced to 23 papers, which represent the
ratio (W/L) of the MCI. The results would be helpful for dentists to pool of studies that provide information required for a quantitative
design the sizes and proportions of restorations of maxillary anterior analysis.
teeth that are pleasing to their patients.

2.2 | Study selection and data extraction


2 | MATERIAL AND METHODS
Articles selected for inclusion were based on the following inclusion
The Preferred Reporting Items for Systematic Reviews and Meta- criteria: (1) articles published dating before April 7, 2020; (2) studies
analysis (PRISMA) statement was followed and consulted during the conducted on participants with normal oral function and appearance
whole process. and with no excessive wear of upper anterior teeth; (3) publications
including the measurements of MCI; (4) studies reporting data includ-
ing mean and SD of W, L, or W/L; (5) a clear report of the measuring
2.1 | Systematic literature search method. The following exclusion criteria were also agreed: (1) sum-
mary, editorials, letters, or case reports; (2) repeated or non-full-text
Systematic electronic and manual searches were conducted in several articles; (3) the research object does not meet the standard; (4) studies
databases including MEDLINE (PubMed), EBSCO, Web of Science, that did not follow the inclusion criteria.
and CNKI. Electronic search was complemented by manual searching These studies were evaluated independently, based on the inclusion/
and conducted to identify randomized clinical trials, case series, and exclusion criteria, by both reviewers (Yingying Wang and Yingshuang
prospective and retrospective cohort studies. Studies before April Song). Any disagreement between authors was resolved by discussion
7, 2020 in these literature databases were included. Terms used in the with a third reviewer (Chun Xu). Figure 2 provided an overview of the lit-
search included “anterior teeth,” “incisor,” “esthetic,” “ratio,” and erature search and article selection in the form of a flow diagram.
“Maxilla.” The relevant articles were from databases' recommended
articles. Full texts of all potentially related articles were obtained from
available sources on the internet. In particular, the strategy of litera- 2.3 | Quality assessment
ture search was as the following: ((((((proportion[Title/Abstract])) AND
((aesthetic*) OR esthetic*)) AND Maxilla*[Title/Abstract]) AND ((ante- A methodological quality assessment was performed according to the
rior teeth[Title/Abstract]) OR incisor[Title/Abstract]))) OR (((((ratio standards described in the Cochrane Handbook for Systematic Reviews
[Title/Abstract])) AND ((aesthetic*) OR esthetic*)) AND Maxilla*[Title/ of Interventions (v5.1.0).23 Two reviewers (Yingying Wang and
Abstract]) AND ((anterior teeth[Title/Abstract]) OR incisor[Title/ Yingshuang Song) evaluated the selected trials independently, and dis-
Abstract]). In total, 23 separate searches have been run to identify an agreements were resolved through discussion or consultation with a
initial set of studies (659). After removing duplicates, the selected third reviewer (Chun Xu). The methodological quality assessment of
studies (441) were screened based on information contained in titles, prospective and retrospective design was evaluated by the Case Series
abstracts, and full texts. The selected studies (77) for qualitative Critical Appraisal Tool from the Joanna Briggs Institute (JBI).24 In the
4 WANG ET AL.

F I G U R E 2 Flow diagram
summarizing literature search and
article selection

JBI Case Series Critical Appraisal Tool, there were more than six specific participants, and W, L, and W/L measurements of MCI including mean
areas with “yes” answers, reflecting the good methodological quality of and SD. In addition, the different classifications including left or right,
the studies. In addition, the different classifications included were the male or female, measuring methods, and ethnicities were also
groups comparable, were cases and controls matched appropriately, collected.
were the same criteria used for identification of cases and controls, was The data were subsequently entered into the meta-analysis
exposure measured in a standard, valid, and reliable way, was exposure software of the Cochrane Collaboration (RevManv5.3.5). Using the
measured in the same way for cases and controls, and were con- random-effects model, forest plots were drawn, and significance
founding factors identified (Table 1, Figure 3). tests were carried out (calculating P values) comparing the following
items: left and right; male and female; actual and perceived; Asians
and Caucasian subjects. Statistical heterogeneity between all the
2.4 | Statistical analysis studies included in this systematic review was not assessed because
all the studies had a different number of participants, measuring
Information was extracted from each included study on the following methods, and descriptive methods, making a comparison nearly
characteristics: year of publication, study design, number of impossible.
TABLE 1 Evaluation of article quality by JBI

(1) Were the


groups
WANG ET AL.

comparable
other than the (8) Were
presence of (3) Were the (4) Was (5) Was outcomes (9) Was the
disease in (2) Were same criteria exposure exposure (7) Were assessed in a exposure (10) Was
cases or the cases and used for measured in a measured in (6) Were strategies to standard, valid period of appropriate
absence of controls identification standard, valid the same way confounding deal with and reliable interest long statistical
disease in matched of cases and and for cases and factors confounding way for cases enough to be analysis Total
Author Year controls? appropriately? controls? reliable way? controls? identified? factors stated? and controls? meaningful? used? score
Yin, W. C. et al. 2010 Y Y Y Unclear Y N N Y Unclear Y 6
Parnia, F. et al. 2010 Y Y Y Y Y Unclear N Y Unclear Y 7
George, S. et al. 2010 Y Y Y Y Y Unclear Y Y Unclear Y 8
Tsukiyama, T. 2012 Y Y Y Y Y Y Unclear Y Unclear Y 8
et al.
Ku, J. E. et al. 2012 Unclear Unclear Unclear Unclear Y Unclear N Y Unclear Y 3
Al-Marzok, M. I. 2013 Y Y Unclear Y Y N N Y Y Y 7
et al.
Calcada, D. 2014 Y Y Y Y Y N N Y Unclear Y 7
et al.
Zhao, Q. et al. 2015 Y Y Y Y Y Y Y Y Unclear Y 8
Sandeep, N. 2015 Y Y Y Y Y N N Y Unclear Y 7
et al.
Rokaya, D. et al. 2015 Y Y Y Y Y N N Y Unclear Y 7
Orozeo-Varo, A. 2015 Y Y Y Y Y Y Y Y Unclear Y 9
et al.
Jain, S. et al. 2015 Y Y Y Unclear Y N N Y Unclear Y 6
Radia, S. et al. 2016 Y Y Y Y Y Y Y Y Y Y 10
Kaisy N. A. L. 2016 Y Y Y Y Y Unclear N Y Unclear Y 7
et al.
Parciak, E. C. 2017 Y Y Y Y Y Unclear N Y Unclear Y 7
et al.
Oh, Y. A. et al. 2017 Y Y Y Y Y Unclear N Y Y Y 8
Shetty, T. B. 2017 Y Y Y Y Y Y Y Y Unclear Y 9
et al.
Bali, Poonam, 2013 Y Y Y Y Y Y Y Y Unclear Y 9
et al.
Hemalatha, 2018 Y Y Y Y Y Y Y Y Unclear Y 9
Kumaravel,
et al.
5

(Continues)
6 WANG ET AL.

3 | RE SU LT S

score
Total

9
9

9
9
Electronic and manual search yielded a total of 659 abstracts. Of note,

appropriate
364 articles were excluded because they did not meet the inclusion

statistical
(10) Was

analysis
criteria. In the second phase of study selection, full-text analysis was

used?
performed for 77 articles, resulting in 23 meeting the inclusion criteria

Y
Y

Y
Y
and was, therefore, included in this systematic review (Figure 2). This

enough to be
interest long
review of the literature is based on 23 articles published from March
meaningful?
(9) Was the
exposure
period of

20, 2010, to July 25, 2019.2,8,9,17,18,20,21,25-34 In all, data from 3603

Unclear
Unclear

Unclear
Unclear
participants were recorded. Data collected was reported from each
study. The details of these studies are described in Table 2.
standard, valid

Using the risk-of-bias analysis (Table 1, Figure 3), 16 studies were


way for cases
and controls?
assessed in a

and reliable

classified as having low risk of bias, 1 study was classified as having a


outcomes
(8) Were

high risk of bias. High risk of bias was caused by the incorrect measur-
ing method for “MEDIA” group.2 In the following analyzation, data
Y
Y

Y
Y

from “MEDIA” group was not used.


factors stated?
confounding
strategies to

Nine papers were included for investigation of the effect of the


deal with
(7) Were

symmetry of left side and right side on the W, L, and W/L of MCI.
Results showed no difference between left and right on W, L, and
Y
Y

Y
Y

W/L of MCI and no heterogeneity in the included literatures


confounding

(Figure 4).
identified?
(6) Were

Eleven articles were included for analyzing the influence of gen-


factors

der on W of MCI, whereas six articles and another six articles were
Y
Y

Y
Y

included for analyzing the influence of gender on L and W/L of MCI,


the same way

respectively (Figure 5). The result showed statistical differences


for cases and
measured in

between males and females on W of MCI, and there was high hetero-
exposure

controls?
(5) Was

geneity in the included literature. Males had wider MCI than females,
and the difference was about 0.36 mm. There was also a statistical
Y
Y

Y
Y

difference between the two gender groups on L, and there was low
standard, valid
measured in a

reliable way?

heterogeneity in the included literature. Males had longer MCI than


exposure

females, and the difference was about 0.42 mm. However, the results
(4) Was

showed there was no statistical difference between the gender


and

Y
Y

Y
Y

groups on W/L.
The data was further subdivided into different groups by measur-
identification
same criteria
(3) Were the

of cases and

ing methods (Figure 5). The result showed no statistical difference


controls?
used for

between two subgroups (“perceived” or “actual”) on W, L, and W/L of


MCI. The data of the “actual” subgroup contained high heterogeneity
Y
Y

Y
Y

as for both W and L of MCI. Although the “perceived” subgroup


appropriately?

showed low heterogeneity as for W and L of MCI.


cases and
(2) Were

matched
controls

Concerning the influence of ethnicity on the MCI size, the data


were divided into two groups: Asian group and Caucasian subject
Y
Y

Y
Y

group. Eighteen papers were included for analyzing W, 11 papers for


other than the

analyzing L, and 12 for W/L (Figure 6). All these included data were
(1) Were the

cases or the
presence of
comparable

absence of
disease in

disease in
controls?

about 1:1 of male to female. The result showed there were statistic
groups

differences between these two groups on W, L, and W/L. Data con-


Y
Y

Y
Y

tained high heterogeneity as for W, L, and W/L.


(Continued)

2018
2019

2019
2014
Year
Rokaya, D. et al.

4 | DI SCU SSION
Kumar, et al.
Aldegheishem,

Melo, M. et al.
Sah, Sanjay
A. et al.
TABLE 1

After reading relevant articles, we selected symmetry of left and right


Author

sides, gender, measuring methods, and ethnicity as potential influence


factors for MCI and chose W, L, and W/L of MCI as indicators.
WANG ET AL. 7

FIGURE 3 Risk of bias graph

TABLE 2 Characteristics of included studies

Number Author Year Ethnicity Total number of Constituent ratio Method


1 Oh, Y. A. et al. 2017 Korea (Asian) 31 16 males:15 females Perceived
2 T. B. Shetty et al. 2017 India (Asian) 100 50 males:50 females Perceived
3 Parciak, E. C. et al. 2017 Asian, American (Asian, 360 80 males:180 female Perceived
African, and White)
4 Radia, S. et al. 2016 London (White) 149 73 males:76 female Perceived
5 A. L. Kaisy N et al. 2016 Kurdish (White) 101 38 males:27 females Cast
6 Zhao, Q. et al. 2015 Chinese (Asian) 101 63 males:38 females Cast
7 Sandeep, N. et al. 2015 India (Asian) 240 20 males:120 female Perceived and cast
8 Rokaya, D. et al. 2015 Nepal (Asian) 150 52 males:98 females Perceived and cast
9 Orozco-Varo, A. 2015 Spain (White) 412 62 males:250 female Cast
10 Jain. S. et al. 2015 India (Asian) 100 50 males:50 females Perceived
11 Calcada, D. et al. 2014 Portuguese (White) 50 20 males:30 females Perceived
12 Al-Marzok, M.I. et al. 2013 Chinese (Asian), India 49 Unclear Perceived
(Asian), Malasian (Asian)
13 Tsukiyama. T. et al. 2012 Asian and White 43 Unclear Perceived
14 Ku, J. E. et al. 2012 Korea (Asian) 80 40 males:40 females Perceived
15 Yin, W. C. 2010 Chinese (Asian) 41 25 males:46 females Cast
16 Parnia, F. et al. 2010 Iran (Asian) 100 50 males:50 females Perceived
17 George, S. et al. 2010 India (Asian) 300 44 males:156 female Cast
18 Bali, Poonam. et al. 2013 India (Asian) 250 21 males:129 female Actual
19 Hemalatha, Kumaravel. et al. 2018 India (Asian) 100 40 males:60 females Perceived
20 Rokaya, D. et al. 2018 Nepal (Asian) 200 68 males:132 females Cast
21 Aldegheishem, A. et al. 2019 Saudi (White) 61 25 males:36 females Perceived
22 Melo, M. et al. 2019 Spain (White) 384 78 males:206 female Cast
23 Sah, Sanjay Kumar. et al. 2014 Chinese (Asian) 147 65 males:82 females Cast

The first factor is the symmetry of left and right MCI. When result is in conformity with the esthetic principle of symmetry. There-
reviewing related articles, it was found that data of MCI dimension fore, following this principle of clinical treatment helps patients
were often divided into left and right sides. In this meta-analysis, the achieve a natural dental appearance. For example, in treating a patient
result demonstrated that there was no difference between the sizes with a single upper anterior tooth missing due to trauma or other rea-
of the left MCI and the right one, which meant no need to divide the sons by implantation, according to the principle of symmetry, consult-
MCI dimension data into these two groups. Studies by Mavroskoufis ing the size and shape of the contralateral MCI will be helpful for the
et al.6 and Gillen et al.35 pointed out the same results with ours. This esthetic outcome of the restoration. For patients with anterior teeth
8 WANG ET AL.

F I G U R E 4 Forest plots summary of comparison between MCI left side and right side. Diamond symbol represents overall mean and 95%
confidence interval for each group of comparisons. P < 0.05 or mean including 0 represents 2 measurements not statistically, significantly
different. Positive values of mean indicate MCI left side measurement larger than right side measurement; negative values of mean indicate MCI
left side measurement smaller than right side measurement

loss or diastema, dentists should divide left and right edentulous these studies told us that face size was correlative with MCI size and
spaces equally and keep MCIs' contact area aligned with the face confirmed that bigger face usually matched bigger MCI. Dentists
midline. should take face size and gender into consideration when making
Next is gender. Previous investigators like Lavelle et al.,36 Cesario treatment plan for MCI. In addition, more potential MCI-related
11,37,38 35 39
et al. Gillen et al. and Sterrett et al. reported that males had parameters of face should be investigated and previous ratios should
wider and longer MCI than females. These results were consistent be verified repeatedly.
with the present meta-analysis. One hypothesis about this result is As for MCI W/L ratio of male and female, some reported that the
that there is a relationship between face size and teeth size. Because W/L ratio of MCI was not affected by gender,35 which was consistent
males usually have larger faces than females, their teeth are usually with the results of the present meta-analysis. However, there were
larger than females. Teeth size to face size ratio has commonly been also reports showing that significant difference existed between males
used to aid denture teeth selection for edentulous patients. Berry and females on the W/L ratio of MCI.42,43 This discrepancy might be
et al.40 proposed the 1:16 MCI W to bizygomatic W ratio firstly, and it contributed to two possible reasons. First, the sample size of the later
41
was confirmed by House et al., whereas this ratio was not recon- articles was much smaller than that of the former ones, which might
firmed exactly by Radia et al. and Hasanreisoglu et al.8,38 Radia et al.8 weaken the power of their conclusions.35,42,43 Second, measuring
found an approximate 1:15 proportional relationship between MCI W methods of the MCI size were inconsistent among these studies,
and bitemporal W and suggested an approximate proportion of 1:18 which might lead to different outcomes. Therefore, the conclusion
for MCI L to total face L and 1:12 for MCI W to face W; but, poor cor- that gender does not affect the W/L ratio of MCI from the present
relation was found between MCI W/L ratio with face W/L ratio. meta-analysis should be reliable. The result of the meta-analysis also
Although there was no unified ratio for the MCI size and face size, suggests that the esthetic W/L ratio of MCI might vary in a range. In
WANG ET AL. 9

F I G U R E 5 Forest plots summary of


comparison between male and female & two
measuring methods. Diamond symbol
represents overall mean and 95% confidence
interval for each group of comparisons. P < 0.05
or mean including 0 represents 2 measurements
not statistically, significantly different. Positive
values of mean indicate male measurement
larger than female measurement; negative
values of mean indicate male measurement
smaller than female measurement. Test for
subgroup shows P < 0.05 or mean including
0 represents 2 measurements not statistically,
significantly different. Positive values of mean
indicate perceived measurement larger than
actual measurement; negative values of mean
indicate perceived measurement smaller than
actual measurement. The letter after study ID
means different group data from a same paper

the present meta-analysis, the average W/L ratio of MCI was The majority of surveyed dentists selected the esthetic W/L ratio as
0.85-0.86. The average W/L ratio of MCI in the Caucasian population close to a value between 0.75 and 0.78 as possible.49 Further studies
8
was 0.75-0.8 in a British study. In other studies, it has been reported are needed in this area.
between 0.72 and 1.24.35,39,44 W/L is an important parameter for Suitable measurement is the basis for the study of MCI dimension
esthetic evaluation of MCI. A higher W/L ratio means a squarer tooth, and other dental-facial measurements. The results of the present
and a lower ratio indicates a longer appearance. Some authors empha- study showed that there was no statistic difference between two
sized the importance for achieving Golden Proportion (GP) of W/L groups with different measuring methods for the W and L of MCI; but,
ratio before,9 which was considered the ideal W/L proportion and was the subgroup “actual” on W contained high heterogeneity. Hunter
commonly used before.45 But new studies contradicted this theory.46 et al. and Priest et al.15,16 found a 0.1 mm difference between cast-
GP established the value of 1:1.6181, 47,48
about 0.618 which is far derived and intraoral-measured MCI W, in other words, between “per-
different from the present meta-analysis result (0.85-0.86). GP is not ceived” and “actual” measurements. We found a 0.09 mm difference
suitable to be regarded as the standard objective esthetic W/L ratio. between perceived and actual MCI W and 0.14 mm difference
10 WANG ET AL.

F I G U R E 6 Forest plots summary of comparison


between Asians and Caucasian subjects. Diamond symbol
represents overall mean and 95% confidence interval for
each group of comparisons. P < 0.05 or mean including
0 represents 2 measurements not statistically, significantly
different. Positive values of mean indicate Asians
measurement larger than Caucasian subjects' measurement;
negative values of mean indicate Asians measurement
smaller than Caucasian subjects' measurement. The letter
after study ID means different group data from a same
paper
WANG ET AL. 11

between the MCI L values of these two groups. There was high het- criterion.2 Study by Ku et al.2 divided participants into two groups,
erogeneity between actual group members. This high heterogeneity one was MEDIA group made up by celebrities whose frontal photo-
reminded that actually measuring the patient's MCI might lack consis- graphs was obtained from the Internet, and the other was NON-
tency and repeatability. Besides, although the absolute value of the MEDIA group made up by dental students. It appeared that MCI of
difference was small, it was significant for MCI with a size of only sev- the NON-MEDIA group had a more square-like-form than those of
eral millimeters. Measuring actual patient's MCI size as a suitable MEDIA group.2 Understanding the public preference for a smaller W/
method for the esthetic evaluation needs more consideration. In con- H ratio of the MCI than is commonly observed in nature, could aid in
trast, reliability and accuracy of using digital images for teeth mea- better decisions regarding tooth sizes during treatment planning.
surements have been proved.11,50,51 In all, the method to measure This meta-analysis had several limitations. First was the small
perceived tooth or face size using digital images showed consistency number of included studies. Second, only data of MCI were collected
and repeatability. This method also allows a larger sample size and and analyzed, although we know all anterior teeth were important for
shorter patient visit time. Therefore, it is more recommended in fol- facial appearance. Further investigations about the relationship
lowing studies on esthetic evaluation of MCI. between periodontal biotype and tooth form/shape and the relation-
The last is ethnicity. A homogeneous comparison between two ship between the form/shape of face and tooth are necessary.
20
ethnic groups by Tsukiyama et al. showed that Caucasian population
had larger W/L ratio of MCI than Asians.20 Significant difference
between MCI size of different ethnic groups was also reported by 5 | CONC LU SIONS
Muller et al.52 Owens et al.53 measured MCI W in several racial groups
and reported variation in most of them. Our results confirmed the Despite the limited number of available studies, the results of this
influence of ethnicity on the dimension of MCI, showing that Cauca- meta-analysis suggested that left or right and measuring methods
sian population showed larger W, L, and W/L ratio than Asian popula- showed no significant influence on MCI W, L, and W/L. Gender and
tion. However, high heterogeneity existed in both Asian and ethnicity were found as influence factors on MCI dimension. Dentists
Caucasian groups. As only a few papers contained data for more than should pay more attention to the principle of the symmetry in clinical
two ethnicities, the meta-analysis could not exclude confounders such treatment for MCIs. Measuring perceived tooth or face sizes is more
as different measuring methods, sample size, and gender distribution. accurate and repeatable when using digital photos. Dentists should
A uniformed measuring method and a clear statement about gender take face size, gender, and ethnicity into consideration when making
distribution are needed in the future studies about the effect of eth- dental treatment plan for MCIs. In addition, more potential MCI
nicity on MCI dimension. In the following clinical practices, taking eth- related parameters of the face should be investigated, and previously
nicity into consideration of anterior teeth esthetic restoration design ratios should be verified.
is necessary.
When analyzing MCI dimension, most of the studies focused on ACKNOWLEDG MENTS
the relationship between W and L. MCI W/L ratio influenced not only None.
teeth appearance but also periodontal tissue. Muller and Eger evalu-
ated the correlation between tooth form and periodontal phenotype CONFLIC T OF INT ER E ST
52
in the Caucasian and Asian population. Results showed that the The authors declare that they have no conflict of interests and all
Asians seem to have a thinner biotype and more slender MCI than authors have read and approved the final draft.
Caucasians.52 Other studies also reported that the tooth form was
related to the thickness of the gingiva and surrounding bone.54-58 This
OR CID
relationship was important for the implant restoration plan at the MCI
Yingying Wang https://orcid.org/0000-0001-5621-1171
site. For example, if the patient exhibits a thin biotype, dentists should
choose a more slender crown which also means a smaller transgingival
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