1. In what way does urine pH affect the excretion pattern of drugs?

Explain your answer in 3 sentences.[ 10 points]

Fluctuations or changes in urinary pH affects tubular reabsorption of

drugs that are partially ionized. In acidic urine, alkaline drugs are more ionized
or readily ionized which means that these drugs are less reabsorbed and
more readily excreted by the body. While in alkaline urine, acidic drugs are
the ones’ becoming more ionized, making these drugs less reabsorbed and
more readily excreted from the body; ionization makes the drugs more polar
and more soluble in water that's why it is more readily excreted out of the
body.

SOURCES:

Tripathi, K. D. (2018). Essentials of Medical Pharmacology (8th ed.). Jaypee

Brothers Medical Pub.