ANALGESICS (NON-OPIOID) INDICATIONS ADVERSE EFFECTS OR CONTRAINDICATIONS DOSAGES or DOSAGES FOR DOSAGE FOR CHILDREN

ADULT
ASPIRIN  Analgesic for headache, toothache, joint ache,  Hypersensitivity  500 mg every 4-6 hrs  10-15 mg/kg q 4-6 hrs
pulled muscle, neuralgia, myalgia, and  Reye’s Syndrome  Half-life 3-6 hrs (PO)
dysmenorrhoea.  GIT (bleeding and ulcers)  Maximum dose= 60
 Preferred for post myocardial infarction and  Increased bleeding (antiplatelet effect) - BASED ON JEN DE LUNA mg/kg/day
stroke patients. not Indicated for those undergoing  Not really used for
 Anti-inflammatory and anti-platelet in high surgery. Oral: Fever, Mild to moderate children
doses  Renal perfusion pain
 Avoid for patients with bronchial asthma.
300-900 mg for 4-6 hours,
 Avoid for patients of peptic ulcer and Max=4 g (4000 mg)
hypersensitivity
 Not indicated for children  Anti-inflammatory:
 Children with chicken pox , flu , or viral 2,400-4,000 mg
infections  Antipyretic and
 Not for Pregnant patient analgesic: 300-2400 mg
 Anti-platelet: 300 mg

IBUFROPEN  Moderate anti-inflammatory effect  Avoid for patients with bronchial asthma.  200-400 mg every 4-6  Children >6 months
(can be used for children)  Less adverse side effects compared with  Similar yet less severe side effects as of hrs old: 5-10 mg/kg/dose
aspirin/better tolerated compared to aspirin other NSAIDS or aspirin q 6-8 hrs (PO)
 Can be used for children and does not cause  Do not use in pregnant women or those  400 mg every 4-6 hrs  Maximum dose= 30
Reye’s Syndrome with active or history of peptic ulcer. most recommended for mg/kg/day or 3200
 Analgesic (soft tissue injuries, after tooth dentistry mg/day
extraction, fractures, vasectomy)
Jen
 Very popular in dentistry
 Chronic pulpitis, periodontal abscess, gingival
For arthritis
abscess.
400-800 mg every 6-8 hours
(Max= 3,200 mg/day)

NAPROXEN  Infrequently used in dentistry  250 mg 2-3 times a day  Children >2 years old:
 Has a stronger anti-inflammatory effect 5-7 mg/kg/dose every
compared to ibuprofen. Jen 12 hrs (PO)
 For acute goat, rheumatoid arthritis,  Maximum =20
ankylosing spondylitis. 500 mg (PO) every 12 hrs, not mg/kg/day or 1250
exceed 1250 mg/day mg/day

INDOMETHACIN  Potent anti-inflammatory agent and good  Adverse effects are high  25-50 mg 2-4 times a day  1-2 mg/kg q 6-12 hrs
analgesic  GI disturbances, CNS disturbances, (PO)
 Treatment of Rheumatoid arthritis, goat, Hypersensitivity  Maximum = 4g/kg/day
ankylosing spondylitis, psoriatic arthritis  Renal dysfunction or 200 mg/day
 Closure of patent ductus arteriosus
KETOROLAC  Potent analgesic with efficacy almost equal to  Increased bleeding (not for surgery)  For IV uses: 15-30 mg  0.5 – 1 mg/kg/dose q
morphine.  GI disturbances, drowsiness, dizziness, every 4-6 hrs (Max= 90 6-8 hrs (IV)
 For renal colic, postoperative pain, and CA skin rashes. mg/day)  Maximum =30
pain.  Orally: 10-20 mg every 6 mg/dose, 120 mg/day;
 Don’t cause respiratory depression, hrs Max: 5 days
hypotension, and dependence
 Administered through IV Jen

20 mg once after IV, 10 mg

every 4-6 hrs, MAX= 40 mg/day

MEFENAMIC ACID  Chronic and dull aching pains.  Weaker analgesic compared to aspirin  250-500 mg 2-3 times a  Above or equal to 14
 Dysmenorrhoea  Diarrhoea day years of age = equal