Find an example for each type of drug interaction and briefly discuss in 2-3

sentences 
AVOID HAVING SIMILAR ANSWERS WITH YOUR CLASSMATES

ADDITION: Aspirin and Acetaminophen: Both of these drugs can be

combined to treat minor arthritic pain, back pain, and muscle aches. They are
considered as the mainstay of oral analgesic combinations and if both drugs
are combined with a narcotic or caffeine, an additive analgesic effect that is
greater than just the two can be produced.

SYNERGISM: Acetylcholine and physostigmine- Physostigmine acts in

inhibiting acetylcholinesterase, an enzyme that breaks down the
neurotransmitter called acetylcholine. As a result, it prolongs acetylcholine
activity and indirectly stimulates nicotinic and muscarinic receptors due to the
increased amounts of acetylcholine in the synapses.

POTENTIATION: Amoxicillin and Probenecid- Probenecid was shown to

benefit/increase the effects of Amoxicillin as Probenecid was shown to
decrease renal excretion of the antibiotics and prolong its serum levels. This
combination is also beneficial in treating infections such as syphilis which is a
type of infection that is diffucult to treat. Moreover, the inhibition effect of
Probenecid to the renal tubule is competitive in nature.

ANTAGONISM: Chelating agents and heavy metals- An example of a

commonly used chelating agents is Dimercaprol, this agent is used as an
antidote to heavy metals such as arsenic, gold, lead, and mercury.
Dimercaprol acts by forming a stable five-membered ring between the
sulfhydryl groups of these heavy metals, thus chelating or canceling its toxicity
and promoting its excretion through urine.

SOURCES:

Beaver WT. Aspirin and Acetaminophen as Constituents of Analgesic

Combinations. Arch Intern Med. 1981;141(3):293–300.
doi:10.1001/archinte.1981.00340030025006

Dawn, L. (2020, July 10). Dimercaprol - StatPearls - NCBI Bookshelf. NCBI.

https://www.ncbi.nlm.nih.gov/books/NBK549804/#:

%7E:text=Mechanism%20of%20Action,-A%20major
 %20protein&text=Dimercaprol%20is%20a%20dithiol%20that,toxicity

%20and%20promoting%20its%20elimination.

Healio. (n.d.). Amoxicillin/probenecid effectively treats syphilis in HIV patients.

Retrieved May 6, 2021, from https://www.healio.com/news/infectious-

disease/20150409/amoxicillin-probenecid-effectively-treats-syphilis-in-

hiv-patients

PDR l Prescriber’s Digital Reference. (n.d.). probenecid - Drug Summary.

Retrieved May 6, 2021, from https://www.pdr.net/drug-

summary/Probenecid--probenecid-1984

Physostigmine | DrugBank Online. (n.d.). DrugBank. Retrieved May 6, 2021,

from https://go.drugbank.com/drugs/DB00981

WebMD. (n.d.). Interactions between amoxicillin oral and antipsychotics-

sibutramine. Retrieved May 6, 2021, from

https://www.webmd.com/drugs/2/drug-1531-3295/amoxicillin-

oral/amoxicillin-oral/details/list-interaction-details/dmid-1080/dmtitle-

selected-cephalosporins-penicillins-probenecid/intrtype-drug