Melanin – The Skin Pigment

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 Melanin – The Skin Pigment
➢ Tyrosinase is the enzyme that catalyzes the production of
melanin.

➢ Excessive production of melanin in the melanocytes of the

skin results in tanning.

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 Skin Lightening
Skin lightening effect cannot be brought about by one single
mechanism.

It can occur effectively only by a synchronized combination of

various biological mechanisms in skin cells.

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 Targets for Skin Lightening

Major targets like Tyrosinase inhibition and Melanogenesis

inhibition

when supported by Antioxidant and Anti inflammatory

mechanisms

the product exerts a positive effect on skin cells, and that is a

crucial step in creating or maintaining light pigmented healthy
and conditioned skin.

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Skin Lightening Nutrients: Key Benefits

➢ Improves skin complexion.

➢ Helps lighten/ remove blemishes and freckles.

➢ Nourishes skin to make it bright and radiant.

➢ Protects skin against harmful UV radiation.

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 Sanat Offers:

➢ Glabridin 40% and 90% from Licorice

➢ Tetrahydrocurcuminoids 95% from Turmeric

➢ Pterostilbene 90% from Pterocarpus marsupium

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Glabridin
from
Licorice

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Common Name: Licorice/Sweet wood
Botanical Name: Glycyrrhiza glabra
Plant part used: roots
Standardization: 40% & 90% Glabridin

Glabridin
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 Glabridin - Mechanism of Action
Glabridin helps to lighten and brighten the skin by inhibiting
melanin formation, mainly by the inhibition of tyrosinase
activity.

Glabridin also has anti-inflammatory effects via inhibition of

superoxide anion production and cyclooxygenase activity.

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Glabridin in Cosmetics

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Glabridin: Anti Inflammatory &
Anti-Oxidation

Anti-Inflammatory Anti-Oxidation
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Glabridin: Skin Whitening

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 Glabridin Dosage

Application Dosage
Whitening & Lightening 0.01 to 1%

Sun Screens & Anti freckle .05% to 0.8%

Acne .01 to .5%

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Glabridin Products

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Glycyrrhizinic acid
from
Licorice

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Common Name: Licorice/Sweet wood
Botanical Name: Glycyrrhiza glabra
Plant part used: roots

Glycyrrhizinic Acid
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Glycyrrhizinic acid – UV-B Protection

Glycyrrhizinic acid is reported to offer protection against UV-B

light-induced damage in human melanoma cells.

Rossi T, Benassi L, Magnoni C, et al. Effects of glycyrrhizin on UVB-irradiated

melanoma cells. In Vivo. 2005 Jan;19(1):319-22.

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Tetrahydrocurcuminoids

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Common Name: Turmeric
Botanical Name: Curcumin longa
Plant part used: rhizome
Active components: 95% Curcuminoids

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 Features

Tetrahydrocurcuminoids offer effective topical antioxidant

protection. Its antioxidant action is of a comprehensive
“bioprotectant” nature, efficiently preventing the formation of
free radicals, while quenching pre-formed ones as well.

This dual action protects the skin cells from damage by UV

radiation and the resultant inflammation and injury with far
reaching beneficial effects on overall health and well being.

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ROS scavenging of THC’s with
Curcumin and Trolox

Radhika Prabhu P, Karunakar Hegde, A R Shabaraya and M N A Rao

Journal of Applied Pharmaceutical Science. 2011: 01(05): 114-118
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 Melanin inhibition in B16F1
mouse melanoma cell line
THC Arbutin

60
% Melanin inhibition

50

40

30

20

10

0
0.375 0.75 1.5 3

Concentration (µg/ml)

Melanin inhibition of THC’s was found to be better than Arbutin

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 Pterostilbene
from
Pterocarpus marsupium

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Common Name: Vijaysar
Botanical Name: Pterocarpus marsupium
Plant part used: bark wood
Standardization: 90% Pterostilbene

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 Thank You
Our Group Companies

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