BASIC PHRAMACOLOGY QUESTIONS FOR TUTORIAL

GROUP 18 (MAXIMUM ONE WEEK)

Write short concise answers on as few papers as
possible in your own handwriting; DRAW TABLES
WHERE NECCESSARY
1. Define the following terms with relevant examples
(3MKS EACH)
 Pharmacology
 Drug
 Receptor
 Toxicology
 Pharmacokinetics
 Pharmacodynamics
 Volume of distribution
 Zero order kinetics
 First order kinetics
 Phase 1 reactions
 Phase 2 reactions
 Pharmacogenomics
 Agonist
 Antagonist
 Partial agonist
 Bioavailability
 Inverse agonist
 Efficacy
  Potency
 Competitive inhibition
 Non-competitive inhibition
2. List and discuss the common routes of drug
administration and excretion with relevant
examples and documented advantages and
disadvantages of each route 25 MKS
3. Summarize the factors affecting drug absorption
and distribution with relevant examples 20MKS
4. Write short notes on (WITH RELEVANT EXAMPLES)
 therapeutic importance of drug metabolism
4MKS
 paracetamol toxicity in relation to drug
metabolism 3MKS
 entero hepatic circulation and drug
elimination 4MKS
 graded dose response and quantal dose
response curves (significance and differences)
4 MKS
 Spare receptors 3MKS
5. Describe 5 transmembrane receptor signalling
methods by which drug receptor interactions exert
their effects 20MKS
6. Describe 2 mechanisms of receptor regulation
4MKS
EXPECTED REVISION TIME = 5 DAYS.