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Corresponding author:
E-mail: Tzipi.Horowitz-Kraus@cchmc.org
Abstract
Reading is one of the most important academic abilities that establishes the foundation for a
child’s success in school. Therefore, early and accurate diagnosis of reading challenges is
crucial for prevention of later academic failure. One challenge in early detection of reading
This article has been accepted for publication and undergone full peer review but has not
been through the copyediting, typesetting, pagination and proofreading process, which may
lead to differences between this version and the Version of Record. Please cite this article as
doi: 10.1111/apa.13738
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difficulties is that the ability to read typically is acquired explicitly when a child is 4-6 years of
age. However, reading ability relies on development of more basic abilities prior to reading
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acquisition, starting from birth. Conclusion: Language, cognitive control, and literacy
milestones can be evaluated and trained from birth to better acquire reading later in life.
Key Notes:
Language, cognition (executive functions abilities), and literacy play a crucial role in
childhood.
Early evaluation of language, cognitive abilities, and literacy is beneficial for early
Reading is a highly adaptive, complex skill that relies on intact language, cognition, and
literacy. Unlike other linguistic and cognitive abilities, reading must be explicitly acquired and
is one of the highest cognitive abilities that the human species has been able to achieve.
Due to specific neural circuits and brain structures developed during evolution, humans are
the only species capable of engaging basic language, cognitive abilities, and literacy into the
foundational abilities. Due to the critical role of reading for both academic and occupational
success and evidence of reading difficulty in 5-15% of children in the US (1) and 5-12% of
children in Europe (2), it is crucial that pediatricians, clinicians, educators, and other
foundational domains in order to identify children with or at-risk for reading difficulties as
early as possible.
(standard scores lower than -1) in one or more reading domains (i.e., word or nonword
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reading accuracy, word or nonword reading fluency, phonemic awareness test, contextual
reading fluency, comprehension), whereas individuals with reading disability (dyslexia) suffer
from much more severe impairment in their reading achievements (i.e., scores lower than -
1.5 standard scores in more than two reading tests) (3). More specifically, dyslexia is defined
as slow and inaccurate reading that continues into adulthood despite remedial intervention
and appropriate literacy exposure, and individuals with dyslexia experience phonological or
orthographic deficits (4). According to this diverse definition, several clinical groups may
suffer from reading difficulties, including children with developmental delays such as due to
dyslexia, attention deficit hyperactivity disorder (ADHD), and autism, neurological disorders
such as in children with epilepsy, psychiatric disorders, and others (see (5)).
How can we screen for reading ability, even before reading is actually acquired? First
and foremost, reading difficulty is heritable with reports of more impaired reading (and
related cognitive-control ability) in children of parents with reading difficulties (6). Therefore,
a simple screen for challenges in this area can be whether a parent or any other immediate
family member suffers from reading difficulties, which may contribute to the existence of
reading difficulties by means of a genetic component only or also due to a lack of home
literacy environment. Even without familial reading difficulties, the foundations of reading
may not be well developed. In this review, we outline language, cognitive, and literacy
developmental milestones that are key to reading acquisition and discuss the scientific
evidence of the development and engagement of relevant neural circuits and cognitive
(alphabetic letters) into their corresponding spoken language sounds (phonemes) and
therefore, reading has both visual and auditory components. To read, one must first visually
identify each letter and decode its corresponding phonological sound using auditory
components (see the ‘Parallel Distributed Processing’ model; (7)). Gradually, the process of
auditory components to a visual pattern that represents a specific word, which is decoding.
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Then, the ‘orthographic’ pathway develops: the child learns to recognize words holistically,
without the need to decode individual letters every time the same word is encountered (7),
which then sets the foundation for a child’s written mental lexicon to bypass the phonological
system. In parallel, the child relates the decoded word to the context and their experiences
based on their oral language in order to identify the meaning of what is being read, a
process known as semantics. The better the semantic abilities are, the easier it is to gain the
meaning of the written word (see ‘Construction Integration’ model (8)). Fluent reading, or the
depends on accurate, rapid decoding of words and relies on intact phonology, orthography,
and semantics, as well as basic cognitive abilities such as attention and other executive
reshaping (or “recycling”) established networks that are originally devoted to other cognitive
functions (10). Specifically, magnetic resonance imaging (MRI) studies suggest that reading
visual/orthographic, and semantic processing, mainly in the left hemisphere (11), together
with frontal regions related to EF (12). Major brain regions identified include the angular,
fusiform, and inferior frontal gyri for phonological, orthographic, and semantic processing,
respectively (see (13) for review). This neuronal recycling depends on both intrinsic
(language and cognition) and extrinsic (literacy) factors that develop from birth and continue
with aging.
Language
The ability to read begins with language development, long before the initiation of formal
instruction in reading (14). Language development, or the ability to listen to and comprehend
oral language, begins before birth as suggested by fetal preference for human voice and
units of sound in a language that can determine meaning (14). Almost all words consist of
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several phonemes blended together, and changing the phonemes affects the meaning (16).
For example, the word “cat” consists of three phonemes (/k/, /æ/, and /t/) and substituting
one phoneme for another (e.g., /h/ for /k/) changes the word. The ability of a fetus to
recognize vowels highlights the fact that the ability to process language is innate (17).
Infants detect native phonemes early in the first year of life and acquire a sense of what
sounds are present in their language. Speech perception in infancy (phonemic awareness) is
necessary for learning to read and is the strongest independent predictor of reading ability
(18). These processes involve temporo-parietal brain regions, including the angular and
supramarginal gyri and the posterior aspect of the superior temporal gyrus (Wernicke’s Area)
(11).
Expressive language begins with cooing, or the production of vowel sounds without
formation of syllable units, within the first 2-3 months of life. Production of sounds containing
both vowels and consonants, or babbling, emerges at age 4 months and continues to
increase in quantity and complexity throughout infancy. First spoken words that typically
occur at approximately 1 year of age mark the beginning of a shift from mastery of sounds to
single-word semantics (understanding). New words are learned slowly between ages 12 and
increased expressive vocabulary, typically developing 2-year-old children can construct two-
word combinations. Toddlers and preschoolers continue to develop their ability to assemble
words into increasingly complex sentences that follow language-specific grammatical and
structural rules. See Table 1 and Figure 1 for language milestones during development.
in verbal ability and proceeds from diffused to localized and from bilateral to left-lateralized
with age and ability (19). Language processing in newborns involves bilateral fronto-
temporal activation, with gradual left shift throughout early childhood (18). Kuhl and
sounds to gradually discern how they are produced (20). Brain activation supporting
receptive (superior temporal gyrus) and expressive (inferior frontal gyrus) language has
been shown as early as at 3 months of age (20). A left-lateralized pattern is relatively stable
by age 4 or 5 years, though a diffuse pattern reemerges during reading acquisition that is
attributed to the difficulty of reading compared to oral language in early stages (21).
involved in cognitive control during language processing (i.e., narrative comprehension) and
along development (22). The researchers suggested that during a story-listening task, better
reading ability was related to greater engagement and therefore activation of regions related
to cognitive control (e.g., the anterior cingulate cortex, part of the cingulo-opercular network).
This demonstrated the critical role of cognitive control in both reading and auditory language
processing.
Cognition
cognitive skills (joint attention) (12). The cognitive skills gathered under the umbrella term
switching/shifting attention, planning, inhibition, and error monitoring (see (23) for the
correspondence between reading and EF). Reading performance has been suggested to
correlate with EF skills (9). Many studies have focused on specific aspects of EF related to
reading: attention shifting and inhibition (24), working memory and speed of processing (9),
verbal fluency (or verb-generation ability) (25) that were all found to be correlated with
reading ability (25). These studies suggest that reading utilizes neural circuits supporting EF
abilities are EF (28). The abilities to keep information in memory, focus attention for longer
periods of time, and draw conclusions based on a text develop gradually and are critical for
intact reading (28). Corresponding to the gradual cognitive development supporting reading
originate in the prefrontal cortex (29), and there is strong evidence supporting the continued
anatomical and functional maturation of the prefrontal cortex related to development of these
skills (30). Despite the main role of the prefrontal cortex in supporting EF, advanced
neuroimaging techniques provide insights regarding several other neural networks also
networks, which are found in young children ages 5-7 years and in older individuals (21
years of age) (31), are engaged during reading and positively correlate with reading skill and
Literacy
Emergent literacy is the developmental stage when children acquire the foundations of
reading and writing, and it refers to the code-based skills essential for understanding the
concept that each letter has a corresponding sound in the spoken language (32).
phonological awareness, oral language, and print awareness, are improved by an enriched
home literacy environment (33) with access to books, parent-child shared reading and
As outlined in Table 1 and Figure 1, during the first 2 years of life, infants and
toddlers master phonemic awareness and other oral language skills that lay the foundation
for later phonological awareness. In enriched home literacy environments, infants become
familiar with books during their first year of life by initially chewing on books and, as cognitive
to turn pages. Between ages 1 and 2 years, children are able to point to and name familiar
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objects, characters, or actions in books and recognize familiar books by their cover. Between
the ages of 2 and 3 years, children recognize symbols and signs in the community and are
able to identify some letters, such as the letters in their name. At the same age, they start
enjoying looking at books on their own, pretending to read familiar books, naming and
describing familiar characters and pictures, and recalling simple story lines. Phonological
awareness emerges between the ages of 3 and 4 years, including sensitivity to syllables in
words, awareness of rhymes, and the ability to identify some letter-sound associations. This
is coupled with print awareness, understanding that pictures are connected in a story and
recognizing familiar words such as their name in print. Children often begin making up
stories at age 3 years and become able to expand on the action in a written story beyond
accompanying pictures. Between the ages of 5 and 6 years, children can appreciate story
sequence and character motivation and, by the age of 6 years, children should be able to
identify and write upper- and lower-case letters and recognize some sight words. Between
the ages of 6 and 7 years, depending on conditional or explicit teaching, children begin to
decode independently, read with grade-level fluency, and use reading strategies such as
rereading, predicting, use of context clues, and asking questions. Most children are proficient
in decoding by the age of 7 years and, by the 3rd grade in the United States, the academic
emphasis shifts from learning to read to reading to learn. See Table 1 for a detailed
The one-on-one interaction during dialogic reading between caregiver and child,
coupled with genetics, is strongly associated with how well a child will perform academically
(34). Language networks provide critical support for emergent literacy, and a critical factor
fueling literacy is the level of verbal stimulation. As stated previously, young readers in
homes that are enriched for reading and verbal communication are empowered to
discriminate between sounds more effectively than those who are not similarly stimulated
(33).
growing brain. Utilizing fMRI during a stories-listening task, Hutton and colleagues provided
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the first association between home reading environment and increased neural activation
(33). Children from more stimulating home reading environments with higher reading
exposure (i.e., with access to books, frequent shared reading, and variety of books read)
cortex, which supports semantic processing and mental imagery and is later integrated into
the reading network. Similar beneficial effect of the home literacy environment on neural
(35).The researchers showed that children at pre-reading stage with a familial history for
dyslexia who had higher scores in the home literacy environment questionnaires, showed
greater activation in the left precental gyrus related to phonological processing and
articulation, as part of a compensatory mechanism (35). It is also important to note that the
occipital lobe, particularly the fusiform gyrus (“Word Form Area”), is stimulated and tuned
from an early age to respond to non-linguistic stimuli, such as faces and objects. The
activation of this region at a very young age is important for its future use for letters and
words processing (36). Interestingly, the fusiform gyrus is “tuned” to recognize letters and is
anatomically close to regions related to objects and facial recognition, which may explain the
Based on the several components contributing to reading success (Table 1), there are
several reasons that underlie a failure in reading acquisition resulting from deficits in each of
During the past 20 years, an extensive body of research has been conducted to identify
neural biomarkers for dyslexia. Several behavioral and neuroimaging studies confirm that
children with dyslexia show decreased abilities and brain activation in three main domains,
visual processing (40). The specific case of dyslexia demonstrates the critical role of several
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key EF in reading development (speed of processing, working memory, and visual attention),
all of which were found to be impaired in children with dyslexia (41) (42). Therefore, reports
of the positive effect of EF training (43) or even video games exposure (44) on reading
abilities are not surprising and may be the key for intervention or even prevention for children
who are at genetic risk for developing reading difficulties, as also has been suggested by
Ozrenov-Palchik and Gaab (45). In his multivariate model for dyslexia, Pennington
strengthens the tight relationship between phonological processing deficits and additional
cognitive alterations (i.e., naming difficulties, speed of processing, attention, and others)
dyslexia (46).
can cause reading difficulties, as is often found in children with ADHD (47). An estimated 18-
45% of children with ADHD have reading difficulties (47). Several hypotheses have been
proposed to explain the comorbidity of ADHD and reading difficulties (see (47) for review),
and at least some cognitive deficits are shared between the two conditions (see “cognitive
subtype hypothesis” (48)). Impairments in several EF, such as speed of processing (48) and
Extrinsic deficits
Reading challenges due to extrinsic deficits can result in an “environmental illiteracy” for
children who suffer from reading difficulties due to inadequate home literacy environment.
Disparities in literacy at school entry stem, in part, from large social-class differences in the
quality and frequency of early literacy experiences (50). Children who suffer from reading
difficulties due to environmental reasons compose the majority of children with reading
difficulties in the United States (51). With the increasing use of technology, the possible
trade-off of less time spent reading a book or shared child-parent reading prompted the
American Pediatric Society to limit on-screen time for children under 5 years of age (52).
currently no objective way to differentiate children with dyslexia from children who suffer
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from reading difficulties due to inadequate home literacy environment. However, accurate
knowledge, but children with environmental illiteracy require more comprehensive and
increased exposure to oral and written language (e.g., through shared reading) to develop
literacy skills (53), and since the source of their difficulty in not biological, it may be reversed
if treated in time.
The complexity of reading acquisition and reliance on intact language, cognition, and literacy
often means that the etiology of reading difficulty is multi-factorial. A child presenting with
psychological conditions. The high rate of co-occurrence between ADHD and dyslexia is a
case in point. Therefore, identifying and addressing deficits that may be contributing to
reading difficulty often require the combined expertise of several professionals, including
health problems, early identification allows for early intervention and increased benefit. One
way to improve a child’s literacy, even before reading is officially acquired, is by utilizing the
principles of shared or dialogic reading. Dialogic reading is a method of shared book reading
in which the child actively participates that has been shown to convey moderate to significant
benefits for expressive vocabulary, oral language, print concepts, and home reading
behaviors (34). Reach Out and Read is one dialogic reading program that aims to improve
home literacy environments via distribution of books at well-child visits and modeling of
dialogic reading and has been shown to positively affect parental attitudes and activities to
encourage early literacy and promote receptive and expressive language skills through
kindergarten in families with low socioeconomic status (54). In these activities, the book is a
catalyzer for a conversation between the parent/care giver and the child and a tool that can
an infant receives a book at 1 year of age, for example, literacy awareness can be measured
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by examination of what the child is doing with the book (e.g., chews or flips pages). Children
with reading difficulty are not typically identified until school-age years, even though reading
development begins long before formal reading instruction. Depending on their role,
clinicians may find specific milestones within each category to be more salient to their
practice. Based on the increasing number of children with reading difficulties due to either
internal or external reasons, we think there is a need for checkup points to evaluate the
Acknowledgements
The authors thank J. Denise Wetzel for review and editing of the manuscript.
No specific funding. The authors declare no conflict of interest related to this work.
Abbreviations used
References
Figure Legends
during ages 0-8 years in the different domains that underlie reading: language (green),
cognitive ability (or executive function; red), and literacy abilities (blue) along age (X axis).
Brain areas corresponding to language, cognitive ability and literacy development are noted
Figures
Figure 1.
milestones can be used as “relatively easy to assess” abilities to screen for developmental delays or difficulties in each domain (Language,
Cognition, Literacy).
* These ranks for naming ability are based on the norms from the Comprehensive Test of Phonological Processing (CTOPP) (60) and the
child’s ability to perceive, process, and name objects/letters fast and accurately.