Anticoagulant Comparison Chart

Which anticoagulant is right for me?

For more information, please visit www.natfonline.org.

Brand name:
What’s the name of the Warfarin*
drug I’m taking? *Coumadin® was
discontinued in
April 2020. Dabigatran Rivaroxaban Apixaban Edoxaban Betrixaban
Generic: Yes No No No* No No
Is there a generic *The FDA approved
available? a generic in
December 2019, but
it’s not available yet.

FDA approval: Stroke prevention Stroke prevention Stroke prevention Stroke prevention Stroke prevention VTE prevention
What conditions is this in Afib in nonvalvular in nonvalvular in nonvalvular in nonvalvular in hospitalized
drug approved for? Stroke prevention Afib Afib Afib Afib acute medically ill
in those with VTE treatment VTE treatment VTE treatment VTE treatment patients
heart valve VTE prevention in VTE prevention in VTE prevention in
replacements patients already patients already patients already
VTE treatment treated for a treated for a treated for a
VTE prevention blood clot blood clot blood clot
VTE prevention VTE prevention VTE prevention
after hip after hip and after hip and
replacement knee replacement knee replacement
surgery surgery surgery
VTE prevention
during
hospitalization
and after
discharge in
adults with acute
medical illness
Prevention of
major CV events
in patients with
CAD and PAD*
*In combination with
aspirin

Drug image and Doses vary 75 mg, 110 mg, 2.5 mg, 10 mg, 2.5 mg or 5 mg 15 mg, 30 mg, or 40 mg or 80 mg
available dosages: or 150 mg capsule 15 mg, or 20 mg tablet 60 mg tablet capsule
What does this drug
tablet
look like and how many
different doses are
available?

Onset:
How long does it take for Slow: Fast: Fast: Fast: Fast: Fast:
the drug to work? Several days A few hours A few hours A few hours A few hours A few hours

Kidney function: No Yes Yes Yes Yes Yes

Should my kidney Kidney function Kidney function Kidney function Kidney function Kidney function
function be considered affects the dosage affects the dosage affects the dosage affects the dosage affects the dosage
before starting this drug?

Food effects: Yes No Yes No No Yes

Do I need to take this Speak with your The 15 and 20 mg Bevyxxa should be
drug with food? Will the provider about doses of Xarelto taken at the same
food I eat affect how the vitamin K intake should be taken with time each day with
drug works? and warfarin food food
Drug interactions:
How many other drugs
may interfere with the Many Few Few Few Few Few
way this drug works?

Routine lab
monitoring:
Do I need to take a Yes No No No No No
blood test to monitor the
medication?

Reversal agents: Yes Yes Yes Yes Not yet Not yet
Are there medications to Vitamin K, fresh Praxbind Andexxa Andexxa Reversal agents are Reversal agents are
reverse major bleeding? frozen plasma, (idarucizumab) (andexanet alfa) (andexanet alfa) being investigated being investigated
prothrombin
complex concentrate
Acute medical illness: Conditions such as pneumonia, Coronary artery disease (CAD): Develops when the Peripheral artery disease (PAD): A condition where
stroke, heart failure, infection, or inflammatory major blood vessels that supply your heart with blood, narrowed arteries reduce blood flow to the limbs.
disease. oxygen, and nutrients (coronary arteries) become Venous thromboembolism (VTE): A term used
Atrial fibrillation (Afib): An irregular heart beat that damaged or diseased. to describe a blood clot that forms in a vein. VTE
can increase the risk of stroke. Nonvalvular Afib Major cardiovascular (CV) events include CV death, includes deep vein thrombosis (DVT) and pulmonary
affects patients without mechanical heart valves. heart attack, and stroke. embolism (PE).
This chart is for informational purposes only. Always consult with your healthcare provider before starting a new medication.