• Master the types complications, the clinical manifestations of otogenic of Bezold abscess, peripheral facial paralysis, meningitis, sigmoid sinus thrombophlebitis and brain labyrinthitis, abscess • Be familiar with the risk signals and diagnostic basis of otogenic intracranial complications, all kinds of otogenic intracranial and extracranial complications and their development Case A 55 year old male presented with otorrhea in his left ear for more than 40 years. Half a month ago, the discharge aggravated in his left ear. The left side had severe headache and high fever at 39.5 °C. Temporal bone CT and head MRI showed that the left side had chronic suppurative otitis media and mastoiditis with sigmoid sinus thrombophlebitis. Case • Questions: • 1. Is chronic suppurative otitis media associated with sigmoid sinus thrombophlebitis? • 2. How does the otogenic infection spread into sigmoid sinus? • 3. How to treat this disease in time? • Brief Introduction • 1.Definition • The extracranial and intracranial complications caused by suppurative otitis media and mastoiditis, cholesteatoma and other ear diseases are collectively referred to as otogenic complications. • If the above diseases are not treated properly or in time, the infection is more likely to cause complications • Because of its special anatomical position, it is often life- threatening, and is one of the critical severe cases in ENT department • Brief Introduction • . 2.classifications • Intracranial complications • Epidural abscess, subdural abscess, meningitis, sigmold sinus thrombophlebitis, brain abscess, cerebral hernia, hydrocephalus, etc • Extracranial complications • > intratemporal complications • Labyrinthitis FP Petrositis, labyrinthine Fistula • > extratemporal complications • Anatomical Considerations • Intratemporal Mastoiditis Labyrinthitis Facial paralysis Labyrinthine fistula Petrositis • Intracranial Extradural abscess -Subdural abscess Brain abscess Meninigitis Sinus thrombophilbitis • extratemporal Retropharyngeal abscess Parapharyngeal abscess • lymphadentitis • Diagnosis • 1. Clinical Manifestations : Intratemporal • 1.1 Labyrinthitis • Fistiula The most common complications of cholesteatoma, paroxysmal vertigo, conductive deafness and fistula test+ • Serous labyrinthitis Diffuse non-suppurative inflammation, vertigo, severe sensorineural hearing loss, and vestibular dysfunction • Purulent labyrinthitis Diffuse suppurative inflammation, severe vertigo, total deafness, unilateral vestibular dysfunction • Diagnosis • 1. Clinical Manifestations : Intratemporal • 1.2 otogenic facial paralysis • Facial nerve edema: acute and chronic inflammatory stimulation • Compression of facial nerve: erosion of cholesteatoma and compression of bone canal • Facial nerve injury: granulation or cholesteatoma long-term compression injury, surgical injury • Diagnosis • 1. Clinical Manifestations : Intratemporal • 1.3 Petrositis • > Headache: ophthalmic branch of trigeminal nerve • > Ear abscess: erosion of cholesteatoma and compression of bone canal • > Fever: <39 °C • > Petrous apex syndrome: abduction paralysis, trigeminal neuralgia, localized meningitis • > Labyrinth irritation symptoms: dizziness, nausea, vomiting, nystagmus • Diagnosis • 1. Clinical Manifestations : Extratemporal • 1.4 Postauricular subperiosteal abscess • The mastoid cortex was broken and accumulated under the periosteum • More common seen in infant patients • Fluctuating abscess behind the ear, ski redness and pain on the surface in acute stage • Form a fistula, which can not be cured and sequela of cholesteatoma • Diagnosis • 1. Clinical Manifestations : Extratemporal • 1.5 Otogenic cervical abscess • > Bezold Abscess : Deep neck • abscess • From the thin bone wall inside the mastoid tip, the pus accumulated to the deep surface of sternocleidomastoid muscle, located in the deep part of the neck under the ear • > Mouret Abscess : Digastric abscess • Diagnosis • 2. Clinical Manifestations Intracranial • 2.1 Thrombophlebitis sigmoid sinus • > The bone plate of sigmoid sinus was eroded and destroyed, perivenous inflammation of sigmoid sinus, secondary thrombosis, growth, shedding and infection • Symptoms: high fever up to 40 °C, chills, headache • Signs: swelling and tenderness can be seen in the mastnid reoinn and nerk • Diagnosis • 2. Clinical Manifestations : Intracranial • 2.2 Extradural abscess • > Definition: abscess is located between dura and temporal bone • > Headache, fever • > Elevated intracranial pressure, meningeal irritation, signs of nerve localization • > Imaging features: dural shadow, middle ear mastoid bone destruction • Diagnosis • 2. Clinical Manifestations : Intracranial • 2.3 Subdural abscess • - Definition: between dura and arachnoid or between arachnoid and pia mater, It often occurs in the old and weak patients. • Symptoms: diffuse headache, chills and high fever, jet vomiting, mental and neurological symptoms • Signs: intracranial hypertension, meningeal stimulation, nerve Do localization • Imaging features: dural shadow, middle ear mastoid bone destruction • Diagnosis • 2. Clinical Manifestations : Intracranial • 2.4 Otogenic meningitis • > Definition: suppurative inflammation of the meningitis • Diagnosis • 2. Clinical Manifestations: Intracranial • 2.4 Otogenic meningitis • > Ear symptoms and signs • > General symptoms: high fever, chills, headache, vomiting • - Meningeal irritation: cervical resistance/neck rigidity, cervical ankylosis, and arcuate reflex Kernig sign(+) Brudzinskin sign(+); • > Intracranial hypertension: headache, vomiting, papilledema • - Mental, neurological symptoms: irritabili • Diagnosis • 2. Clinical Manifestations Intracranial • 2.5 Otogenic brain abscess • > Definition: ear disease causes pus to spread into brain parenchyma, mainly in temporal lobe and cerebellum • > The most dangerous and common brain • > The diagnosis was confirmed by imagine examination • Diagnosis • 2. Clinical Manifestations Intracranial • 2.5 Otogenic brain abscess • > Stages of progression • Onset (localized encephalitis or meningitis, about days): chills, fever, headache, vomiting, mild meningeal stimulation; • Dormant period (suppurative period, lasting for 10 days to weeks): the symptoms were not obvious or light; • The obvious stage (abscess formation period, time is different): • Diagnosis • 3.Assistant Examinations • 3.1 Lab test • - Blood routine test: WBC count and polymorphonuclear leukocyte count increased • - Lumbar puncture + CSF pressure, routine, culture: helpful for the diagnosis of intracranial complications • - Hearing : identify whether cochlea and auditory are abnormal • - Vestibular function examination: whether the semicircular canal and otolith function are abnormal • Ophthlmoscope: papilledema • Diagnosis • 3.Assistant Examinations • 3.2 Imaging examination • - CT scan of temporal bone: most of otogenic intracranial and extracranial complications can be identified, thin-layer, magnification • > MRI of inner ear and internal auditory canal: differentiation of abscess, effusion, hemorrhage, tumor and inflammation • Diagnosis • 4.Maps to diagnosis • 4.1 history of otogenic diseases: otitis media, cholesteatoma of middle ear, etc • 4.2 in case of any of the following situations, it shall be regarded as a dangerous signal: • - Sudden reduction or cessation of ear pus (obstruction of drainage) • * Severe ear pain, headache • * Cold, fever, chills • - Vertigo, nausea, vomiting, change of mind, etc • Diagnosis • 4.Maps to diagnosis • 4.3 Susceptibility factors • > Virulence of pathogenic bacteria: Pseudomonas aeruginosa, Staphylococcus aureus, Streptococcus • > Patient resistance: weak, old man, infant • - Poor drainage • Diagnosis • 4.Maps to diagnosis • 4.4 Anatomic pathways • Complications Pathways Bone Vessels, bone erosion, Preformed Pathway ,Labyrinth IAC/CA • Etiology & Pathogenesis • 1. Etiology • Inflammation destroys bone wall • Poor health: severe chronic disease, weak resistance, malnutrition • Virulence: Gram negative bacilli, Staphylococcus aureus • Etiology & Pathogenesis • 2 Infectious and spreading approaches • > Peripheral bone destruction • > According to anatomic pathway: vestibular window, cochlear window or bone suture • > Blood Route • Treatment • Therapeutic principles • > Elimination of primary ear diseases • Treatment of intracranial and extracranial complications • > Symptomatic support • - Different treatments for patients with different complications • Treatment • Surgical Options • - mastoidectomy • - facial nerve • - inner ear • - intracranial • Sufficient broad-spectrum antibiotics • Reducing intracranial pressure; mannitol, corticosteroids • Supportive treatment • Summary • The main way of otogenic intracranial complications? • Which middle ear diseases are more likely to cause otogenic complications? • What are the common intracranial complications? • What are the common complications in temporal bone? • Common extratemporal complications in infants?