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Vestibular evoked myogenic potentials in early Crevits L., Venhoovens J.

,
Debruyne J.
stage of MS and clinically isolated syndrome Departement of neurology, Ghent University Hospital, Belgium

ABSTRACT Introduction and Purpose RESULTS


Background and purpose Brainsterm and cerebellar lesions are common in early
Brainstem and cerebellar lesions are common in clini- stages of MS and CIS. However, many of them might
cally isolated syndrome (CIS) and early multiple scle- be subclinical. Testing with VEMP is thought to be a
rosis (MS). Many might be subclinical. Testing w10ith marker for brainstem function. Therefore, we studied
vestibular evoked myogenic potentials (VEMP) is VEMP in patients with early MS and CIS
thought to be a marker for brainstem dysfonction.
The aim of the study was to test VEMP in early stages Methods
of MS and CIS Subjects:
20% outpatients with CIS or early MS 75% without any
Material and methods infratentorial sign or lesion on clinical examination
Collic and ocular tap-VEMPs in a group of outpatients and MRI 20 age matched healthy volunteers
CONCLUSIONS
with CIS and early MS where compared to age –mat- Collic and ocular VEMP latencies of the patients were
ched healthy volunteers .75% of the patients did not Methods: significantly prolonged. These findings suggest that
have any infratentorial lesion on MRI and critical exa- Tap-VEMPs: evoked by forehead taps with a triggered VEMP is a rather sensitive test, able to detect subclini-
mination. Peak latencies and standardized amplitudes reflex hammer. Registration:over the middle part of cal dysfunction or lesions beneath detection threshold
were measured. the belly off the sternpcleidomastoid muscles (collic of MRI in patients with early MS and clinically isolated
VEMP) and over the middle part of the lower eyelid , on syndrome..
Results and conclusions top of the optical edge (ocular VEMP). During the collic
Collic and ocular VEMP latencies of the patients were VEMP, subjects had to push the chin downward with a
significantly prolonged compared to healthy constant pressure. During ocular VEMP, subjects had to
volunteers.The standardized p13n23 amplitude was deviate the eyes 25 degrees upward.
significantly enhanced. These findings suggest that
VEMP is a rather sensitive t'est, able to detect subclini- Measurements
cal dysfunction or lesions beneath detection thres- Peak latencies and standardized amplitudes
hold of MRI in patients with early MS and CIS

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