Serum values of inorganic phosphorus and sodium increased, while calcium, magnesium and

potassium concentrations decreased. Increase in blood lactic acid levels. Upon induction of SARA,
an increased concentration of toxin (LPS) is observed within several compartments of the rumen. Blood
Urea level increases in both sara and acute rumen acidosis. Blood glucose concentration is also increased
in grain associated SARA Rumen pH depression triggers the release of vasoactivesubstances, such as
histamine and LPS, which damagethe capillaries of the lamellae in the foot, thus causinghemorrhage,
inflammation, and lameness (Nocek,1997). Endotoxin in blood and rumen fluid can be detected following
ruminal acidosis, as ddamaged ruminal epithelium allows for uptake of

Dehydration is reflected by increased

hematocrit, BUN, creatinine, and total
protein. Leukocytosis (stress) may occur.
Hypokalemia and hypocalcemia. Alkalemia.
The acute phase reactants serum
amyloid A (SAA) and haptoglobin are markedly
increased within 6 to 12 hours and 18
to 36 hours, respectively, of experimental
induction of acute ruminal acidosis, whereas
a much smaller increase in serum fibrinogen
concentration was present after 24 hours