Alloxan Alloxan Alloxan

Experimen HFD Alloxan DM&50m DM&100 DM&200

1.0 tal g\kg mg\kg mg\kg

treated
Curcmi Curcmi Curcmi
Groups Mean ne Mean± ne Mean± ne Mean±
DM
SEM SEM SEM 1.0

HFD
Mean±
Test SEM Mean

Parameter
s 186.5
400.0
235.9
Glucose 375.93±22. 248.3±13.5 188.2±5.5*
±16.3***
350.0 6*** *** ** 15.8

(mg/dl)
300.0 186.5±15.8

250.0

200.0

150.0

100.0

50.0

-
 Alloxan Alloxan Alloxan
Experimen HFD Alloxan DM&50m DM&100 DM&200
tal g\kg mg\kg mg\kg

treated
Curcmi Curcmi Curcmi
Groups Mean ne Mean± ne Mean± ne Mean±
DM
SEM SEM SEM 2.0

Mean±
Test SEM

Parameter
s
8.98 ± 0.39 6.48 6.72 6.25
HbA1c HbA1c
4.45 ±.38 *** ±0.39*** ±0.34*** ±0.41*** 4.5
% 0.4
C– .38± 0.72±0.4 .83±0.4 0.97±0.5 C–
peptide 1. 7± 0 .9 0.03*** ** *** *** peptide 1.7
(ng/ml) 0.9

Table (8): Effects of (100,150,200mg\kg) of Oral Mangeferin Extract on Ad

Alloxan Alloxan Alloxan
Experimen HFD Alloxan DM&100 DM&150 DM&200
tal mg\kg mg\kg mg\kg

treated
Groups Mean
DM Mangefe Mangefe Mangefe
rin rin rin
Mean± Mean± Mean±
SEM SEM SEM
Mean±
Test SEM

Parameter
s
 Leptin 148.5
108.5±3.7* 91.5±5.69* Leptin
(ng/dl) 91.00±4.6 148.5±6.1Ɨ 115.9±3.8* ** **
**
6.1

295.4

295.4±10.8 325.3±17.2 364.8±10.7

335.09±13. Adiponecti
Adiponecti 8Ɨ 7Ɨ *
23 Ɨ n (µg/ml)
n (µg/ml) 350.27±18.
03 1.9

30.32 ±2.2 22.60± 18.63±1.68 15.47±0.7*

Chemerin
24.85±1.6 Ɨ 0.8** *** ** Chemerin
30.3
(µg/ml) 2.2

23.16 ±1.7 30.02

SOD 31.13±1.96 33.62±1.51 SOD
Ɨ ±1.97 Ɨ
(u/L) 30.01±2.58 * *** (u/L) 23.2
1.7

25.85
37.10±1.71 39.60±1.87 42.80±2.33
GPx (u/L) ±1.66 GPx (u/L)
33.57±2.88 ** *** *** 25.9
1.7

Table (9): Effects of (100,150,200mg\kg) of Oral Mangeferin Extract on Ad

Alloxan Alloxan Alloxan
Experimen HFD Alloxan DM&100 DM&150 DM&200
tal mg\kg mg\kg mg\kg

treated
Groups Mean
DM Mangefe Mangefe Mangefe
rin rin rin
Mean± Mean± Mean±
SEM SEM SEM
Mean±
Test SEM 4.0

Parameter
s

375.93±22.
Glucose 247±8.9 *** 243±9.30 217±12.6
186.46±15. 6*** *** ***
8 186.4 375.0
(mg/dl) 15.8 22.6
Table (9): Effects of (100,150,200mg\kg) of Oral Mangeferin Extract on Ad
Alloxan Alloxan Alloxan
Experimen HFD Alloxan DM&100 DM&150 DM&200
tal mg\kg mg\kg mg\kg

treated
Groups Mean
DM Mangefe Mangefe Mangefe
rin rin rin
Mean± Mean± Mean±
SEM SEM SEM
Mean±
Test SEM
200.0 185.5
Parameter 180.0 176.4
169.2
s 160.0
Alloxan140.0 Alloxan 136.2

185.53±12. 176.41±4.2 169.15±7.1 136.24±6.2 120.0 111.0

Cholestero 183.07±14. 2Ɨ 0Ɨ 2Ɨ * 100.0 9
l(mg/dl) 92 185.5 176.4
80.0
12.2 4.2
60.0
111.31±10. 94.14±5.7 87.03±4.7 77.73±6.4 40.0
TGs 89.33 ±
3Ɨ Ɨ Ɨ **
(mg/dl) 6.4 20.0
111.0 94.0
1.3 - 5.7
Cholesterol(mg/dl) TGs
89.89±5.4 67.10±2.7 58.60±4.08 47.60±4.09
LDL-c 61.76±3.3 ** ** *** ***
(mg/dl) 89.9 67.0
5.4 2.7
27.96±2.33 30.47±1.67 30.62±2.63 32.95±2.12
HDL-c Ɨ Ɨ Ɨ Ɨ
(mg/dl) 31.44±1.97 27.9 30.0
2.3 2.0
Alloxan Alloxan Alloxan Alloxan DM&200mg\kg

treated D Curcmine Curcmine Curcmine Mean± SEM

375.9 248.3 235.9 188.2

250
22.6 13.5 16.3 5.5 Alloxan SEM Ṯ

200 185.53 Alloxan DM&50mg\kg

172.3

150 Alloxan DM&100mg\kg

135.3
111.31 Alloxan DM&200mg\kg
100 87.48 89.89

61.64
47.48
50
27.96 30.62

187.1 94.55 80.87 64.78 30.47 32.95

0
Cholesterol(mg/dl) TGs (mg/dl) LDL mg/dl HDL mg/dl

10.0
8.9 Alloxan
9.0
Alloxan DM&50mg\kg
8.0
Alloxan DM&100mg\kg
7.0 6.7
6.4 6.3 Alloxan DM&200mg\kg
6.0
5.0
4.0
3.0
2.0
1.0 0.7 0.8
0.4
-
HbA1c C –peptide
 4.0
3.0
2.0
1.0 0.7 0.8
0.4
-
HbA1c C –peptide

HbA1c

8.9 6.4 6.7 6.3 4.5 0.4

0.4 0.4 0.3 0.4 8.9 0.4

0.4 0.7 0.8 1.0 6.4 0.4

0.3 0.4 0.4 0.5 6.7 0.3
6.3 0.4

erin Extract on Adipokines and Antioxidant Levels in HFD Alloxan Diabetic Rats.
 115.9 108.5 91.5 Leptin Adiponectin (µg/ml)

3.8 3.7 5.7 148.5 6.1 295.4 1.9

115.9 3.8 325.3 17.3
325.3 335.0 364.8 108.5 3.7 335.0 13.2

17.3 13.2 10.7 91.5 5.7 364.8 10.7

400.0
364.8 Alloxan
350.0 335.0
325.3
22.6 18.6 15.5 Alloxan DM&100
295.4
0.8 1.6 0.7 300.0
Alloxan DM&150
250.0 Alloxan DM&200
30.0 31.1 33.6 200.0
2.0 2.0 1.5
148.5
150.0
115.9
108.5
100.0 91.5
37.1 39.6 42.8
1.7 1.9 2.3 50.0 33.6 37.139
30.322.6
18.6
15.5 23.230.031.1 25.9

-
Leptin Adiponectin (µg/ml) Chemerin SOD (u/L) GPx (u

erin Extract on Adipokines and Antioxidant Levels in HFD Alloxan Diabetic Rats .

400.0 Glucose
350.0
300.0
250.0
200.0
150.0
100.0
50.0
-

247.0 243.0 217.0

8.9 9.3 12.6
erin Extract on Adipokines and Antioxidant Levels in HFD Alloxan Diabetic Rats .

185.5
176.4 Alloxan TGs
169.2 Cholestero
(mg/dl)
Alloxan DM&100mg\kg l(mg/dl)
Alloxan
136.2 Alloxan DM&200mg\kg Alloxan DM&150mg\kg Alloxan 185.5 12.2 111.0
111.0 Alloxan DM&200mg\kg
94.0 89.9
87.0
169.2 136.2
77.7 Alloxan 176.4 4.2 94.0
7.1 6.0 67.0 Alloxan 169.2 7.1 87.0
59.0
48.0
27.930.030.632.9
87.0 77.7 Alloxan 136.2 6.0 77.7
4.7 6.4
Cholesterol(mg/dl) TGs (mg/dl) LDL-c (mg/dl) HDL-c (mg/dl)

59.0 48.0
4.0 4.0

30.6 32.9
2.6 2.1
 C–
peptide

1.7 0.9
0.4 0.3

0.7 0.4
0.8 0.4
1.0 0.5

betic Rats.
 Chemerin SOD (u/L) GPx (u/L)

30.3 2.2 23.2 1.7 25.9 1.7

22.6 0.8 30.0 2.0 37.1 1.7
18.6 1.6 31.1 2.0 39.6 1.9

15.5 0.7 33.6 1.5 42.8 2.3

Alloxan

Alloxan DM&100mg\kg

Alloxan DM&150mg\kg

Alloxan DM&200mg\kg

33.6 42.8
37.139.6
5.5 23.230.031.1 25.9

n SOD (u/L) GPx (u/L)

betic Rats .
betic Rats .

LDL-c HDL-c
(mg/dl) (mg/dl)

1.3 89.9 5.4 27.9 2.3

5.7 67.0 2.7 30.0 2.0

4.7 59.0 4.0 30.6 2.6

6.4 48.0 4.0 32.9 2.1