విటమిన్ ~B7

B7, H, Biotin

. , к"# $% &'(к) *+, .
&- ./0123 45678+, . 7 '( *5*&91 *56: ;<% =>?5 :@A
A(+1 х
CDA<E . A "+,FGH . ) к)&/ &'( яJK?L)
M=(FGH . я4N @OPA G2&Q ?RA O?S M=(FGH . 456ATUV W
45?A<% я
CDA :@A XA . ;*YZ+, - B7, H, Biotin- R&O $[)=(\
A "+,к)&<& !. K&' A(']R&OA O$SX) .@]A F=& @R&OA
*5^ O?S _?5

&O O?S F=& ?RA G23' *YÀ( =&*5<E&aH ...
bcd ,Vitamin H,Biotin ,4e.
<f 48_ bcd (Vit H - 4e).&gh . ' bcd' A& ij&OA Nbck/5%lmn3 *5@&
l ?8_q1 ") *&9(к)&r&<E. шqg&1 t

9>m op _ l Fu vA(, \wxy z {A( 8&65&O
9g}& "~ /04gк)&/ g0=L (&<E. <f к) 25

CDFKK) M=(FGH.
.&a% *<) : H@, /0&OA +,l... 'w3A G1 .
к кR7 -=&ly (B-complex). 1916 1 4} кA(gh ( B7)
H < &я3 = 8R R . к/ m)xLgh . Biotin 1к tetrahydrothiophene R&
кH "# W к ureido (tetrahydroimidizalone) R& *5&?& &<E. к valeric 8_
*5$ _8 tetrahydrothiophene R& к gN .`@Y к .A(=&X&94+,?&<E.
l x# , R8 Gw3 ?8_q1A( , к &я3 = 8R, R8

Biotin \@Yv _
"#5 pA( , \@Yv l ?8_gW-'t

l Feя' 1 "?5 "# =L (&<E.
xXg` `(general view):
l ) ?Z6L , R8 \@Yv) R8 .

CD _
Biotin n{ mngh', \@Yv _ l :@K8 к)
.@=g&. ;<E :@gx8A шL v=K8 <v *5K8 =&'g& +,'W 5 8_
9кK& 1 к "?5 "# =L (&<E. Biotin ^ :@K8 *569g 1 = 8 *+,? , gN +8_S
4<E =]кR=L (&<E. Biotin ?g9( ry R8 ghl 41m ?& F=& oghS a%84/0&<E.
¡H?&, ;<E, ry R8 9g}& F=& .Qк x¢&'g x^) R8 ?Z?
L 1
кA4+,?&<E.;<E ry < 9g}& <v Kb£&9+& x^ & '(.
xXg`&, m 4¤yR8_ шqg к Gq .@=) к&- к)@ biotin ?Z6L a%8+& @A
Biotin 1*& .gh'(. g`&, .Qк <%1 9y 4'

CDA =&=¥ ), <]g`к) USA R8
yzH8_, biotin A( Gq M=(F@+& =>O&9 '(. .W$%, к @ L к :@K8 .xXg`
:@gx8A9g A*Y+, biotin 1") .Qк& W.
Biotin к ¦L §8 =>?5& (C10 H16 O3 N2 S) . Biotin .xXg` }` кHR &r&<E. ;<E
кH "# WA &+, n3 @¨$L) &<E. &+, n3 @¨$L) imidazole R8 ©Eeª¦ W.
Biotin к heterocyclic («-) carboxylic 8_ S-кHR &<E. Biotin t+, &я3)
<v &+, *¬gv), . R8 pimeloyl-CoA A(&/0 ?8_g@Y?&<E. 8-
CD-7-
oxopelargonic 8_ synthase к pyridoxal 5'-o ® &я3¯. pimeloyl-CoA, xygy к
malonyl thioester "°±A к O@R _ghZ \@Yv l& . 7,8-Diaminopelargonic l& (/")
aminotransferase, NH2 <? (AdoMet) S-adenosylmethionine *eR&O .xXg`
&<E. Dethiobiotin synthethase ATP $² 8_yG®

Q .W к /" carbamate <v ureido R&
gZ+ $%³´g`. /0к{ к deoxyadenosyl 1 Biotin synthase reductively cleaves
AdoMet -. Dethiobiotin A Zr ' /0к{ &я3¯ кHR A ;A(-= (Fe-S)
7&'5& кA(A4/0&<E ;<E = <?, <v Oк)\ &<E.
Cofactor :@gx8A=L §&

Biotin /0 (+) .Qк carboxylase &я3) 1 gN +8_S 4<E 4^ ? к cofactor &<E:
* µ3{-CoA carboxylase _,
* µ3{-CoA carboxylase ¶,

* Methylcrotonyl-CoA carboxylase,
* Propionyl-CoA carboxylase,
* Pyruvate carboxylase,
4y \@Yv l& ?8_q1, х-)=( .

CD l& :@A 9g к) *e*+, шL +,'
a%8, "#5 pA( gh8 \@Yv lA(&/0 ?8_gWA t

l F 1 х
CDA<E. Biotin
=eя8 carboxylases 1 R·y w3 ¸l¹ mS1-.

CD =t]& яº/0&94/0.
biotinylation =Z&'A ATP .@=g& R8 holocarboxylase synthetase <v $%³´gк. ^
gx8A n3lк) biotin к .a[}&® "#5 p x¥¤кg`, "#5 p *g=Zg, DNA *R@RL?, R8
7ml7 = ^ *5K8 .^ 8A& к х

CA
D *5e x&76к? *eR&9@9(P.
<к<% Biotinidase b£xy # "#5 pAl ( biotinylate a[8 / »gh m)xLgh \<E· biotin
=]я& FK_ я? кm=L (&<E.
Biotin 4& 1 =eя8 4& =»m&a%, 4

CDA $[HA "#5 p-w3& *g=Zg к ;<E 10-
15 кK_ к ¼A ¥g& KD, $², tetrameric "#5 p avidin (к/ streptavidin R8
neutravidin) a_ к½RA binds. ?g9( ^ :@ x&76к .ml 7A(l *eRxL gh. 2005
@gк), a_ к½RA *R¥ ?A( biotin-streptavidin 4& & .@=g& &94+,$²&<E.
Biotin к sources:
Biotin g&1, g @Agh =L ¨? &9(A( , .W$% \ х & Rd t_) W.
biotin к&µ&®.XEк &a% ) - v 9· , /0 +,¾, K+,¾1 &/% *9P x~ A (.W$%,
+,¾ ¸v?(white) e& $² K+,¾1 &/% *9P x~ A к biotin *5G ?R±=L (&<E),
8&, \ кg8) R8 GQgh¿A. "P? я 1 g biotin M=(F@+& 35 @gк)
70
CDFK K¯S / d (143-287 nmol / /0) Ar
l .&9 &<E.
Biotin к/ &'() A(&/0 .&'(4r1 &<E. 1940 1 '' He Sternbach R8 «n GÀ{
w¾ Á± '' .@¨<E &Â *5K8 "5g&i *<g & fumaric 8_ *eRagh .
4eG23Hp--
Biotin к/ H (H "] & ]Ã®", "ry R8 9g}" F=& German *<)
=>O=(L&<E) < B7 . m)xLgh. Biotin к =_A

CDA :@ i ?A( A =y /Ä )к)
R8 F/0ml) 1 gvb£&O a%84/¾W. .^ 8) A(&/0, яRRA<E biotin =_A

CDA :@
i ?A( g eR&9&$²"r < к g 4y , ?к)@ < GQR84{ &+@9(P .
R&agh. xXg`&, biotin "#5 p G2ÅÆV gÇ*&1 < biocytin @& g 1 &<E. "#5 pu
<v "#5 pAl ( OÈAW *5K8 &'( É` .@=g&. *5K8 O? biotin .=(ÊË . biocytin
R8 "#5 p-G2ÅÆV biotin A(&/0 +,' кяÌA 1 biotin *5=L (?& ?`
i &;. .W$%,
a_ R&я) biotin к 20-40% @gк) g`& =_A

CDA :@ i ?A( R&O кHR Biotin
=_A
CDA :@ i ?A( 1 =L ¨? G23X к x^ & @g`. ;<E g& A(&/0 ^ biotin-
"#5 p 4&Â( к : к x¥Í g`& &r&<E. к : 4&^& g *<g &
A(&/0 biotin к =_A

CDA :@ i ?A( gÎ W=(L&'Q<E '( .
Biotin .@=) *5?& a% .&) --
"&? biotin ¥6 "¢AÏ*YA $[H8'(, ' "A 1 =g¡ ?к)@ &+& biotin x¥W)
=&i@& xXg` я 1 к)@ кA(A4/0&<E., biotin xm & ?к)@ x¥W1 "0к
nyzyF» A < ;?g .l? g`), 4 ), epileptics, mn'· @8=( GR, R8
l . g Xg` R8 9A(4H@v+& t?5& 1 biotin RL&9+& яRR&<E . R`Ñ 1
.Ð[l r
4e 4Ò Hя& к)@ &++ RL&9+& яRR&<E . ^>"A 4e e
к)@ a%8A(.
/[ª8S
Biotin 1*& .gh'(, $%Hк", R8 iqL $² *RR&9@9(P. ._& 1*& /0 +,¾ ("#5 p
avidin .XEк x¥W1 кHR A), &+, < .&?к&- к)@ +к4Óy +,¾ a_ 2)... Ô
6A+ @A biotin 1*& <RM=(L&<E. /0 "#5 p 4e A( 4Ó3& a%=L (&<E .
я&?@Y) 1 biotin 1*& '- я&?@Y) /0 +,¾ $[l 6m¦&O &agh. )кк) +,¾
$[l "#5 p ;@v+ @& 9g}, 7ш Ay&, .1m 8_, R8 +,к), к&+gк) =&4&XE&OA
*a%8к"# @+& &agh . &/Õ5 ¯ +,¾ $[l 8& . R8 +,¾ $[l кm&a% к l ÖF
"#5 p avidin . кA(A4/0&<E. Avidin, GQ/0 (@&) @A denature .WA&'(A Biotin
a[к)a['gк)&/ &r&<E .
Biotin 1*& к `):
* bcW Ay& (.1m 8_)
* к&+l кк
кTUV, к), gh, R8 яAQ&<E58 "5&?& 9(×

y к "~ g) /0A $²)"~ )=( @& gh*Y
Ø gÇ*&1 9g}ÉÂA((/[g}µ3 ) @A .

L , 6i5`, '(·4gh R8 я'R&9& .
A> _jк{ `)- ш, '(g?
xvк х Ø, кH к .xXg` х \@Yv *&m`Ù, "biotin-1*& х&" (biotin
deficient face) \&?&<E *Y`) @RÎ&agh . Biotin 1*& к @&A(? gh}?) A
@ к)L) 4¤yR8{ R8 ¡&{ ;2 к) mnRRA K]`Ú? = , 4bÛA*/0A ^к @ @=¥
*Mgh A( &agh .
R`Ù ¦L §) biotin 1*& к к)@ Ay& кHR &W. R`Ù ¦L §) <<*Y =& biotin
?R±"# WA ¥6 *56&&a% 3-hydroxyisovaleric 8_ .xXg` mngh', . *RÉÂ
9>m&O&<E. g& =8&1 .@ш& biotin 1*& ÜÝ@Y) '*Yryк$² @OPA
malformations(cleft palate) @9(P . GQ<E&O&<E .^ 8) $[)*Y?W .
:@K8_ 1")
Biotin-XR? carboxylases к 1*& 9g ) кHR Gg=?v& :@K8 1") 4]ÞT
carboxylase 1*& . m)=(Lgh. &я3) holocarboxylase synthetase <
biotinidase 1 1"A( W. Holocarboxylase synthetase 1*& =g¥ @&?& biotin
*eR&O A(&/0 шqg& к к`) XE=L (&<E, .&'(@A 4]ÞT carboxylase *569g )
=&кgß ` 4eк{ R8 G23' .@ L W:. Ketolactic gкL 1 l^g}&, &<f58
t?5A .XEк l "# @Y, hyperammonemia, 9g}& ''(·ghl, <` == ),
C?L4/0, tgÈ), .@¨<E = &, .1m 8_, R8 F_.
Biotinidase 1*& =R"# biotin g`& '(, .<E *5K8 . &я3) к 1*& @gк).
Biotinidase biocytin R8 biotinyl-mnmy nàS (*56 holocarboxylase к proteolytic
.XÕ кg`& ?Z?

L )) A(&/0 biotin к áHк $%³´g` R8 ?<v biotin recycles. ;<E
g "#5 p-G2ÅÆV biotin A(&/0 biotin L 1 к/ a_ х

CDA<E. яAg{ `) ?R±&<E
кH R8 mngh' W. 9g}=&4&^ `) 9g}ÉÂ, .1m 8_ (ry Ay&) R8
achromotrichia (ry 1 A*YZ+, < @gÎ '5@ & F1Z@+&). Perosis (к) к к)l*L
CDA
R8 *)94/0A*Y+,) .¥*&яg& 1 &9@9(P . \@Yv 8& R8 t?5m&/
&/Õ5 ¯ (FLKS) R8 8 9g} $[3 K&^( G XE к/ =&i&9@9(P.
*e)
+8_4Ó--^(
]& biotin iqL · "~ &'@9(P. ;A(SH-XR? R8 -;A(SH-XR?
&+, ^(
]& 1, biotin $² iqL gкL 9g 8&?5`
Cgh*g9/ R8 ?к)@ *G=&
l Fu x¥WA( =v8& @, \ .^ 81 *G=& t

gкL t l Fu 1 ?R±&*Y 50 ?&
l Fu 8&?5` =&4&^& '(·4gh R8 я'R&9& &+,

.XE&agh . Biotin к/ t
?R±&9+&, ?g9( ^(
]& =&4&^& A> *6 GR&9+& "?5 "# xL W.
bcW & gh == )
biotin 1*& O ) R8 `) M@5& 1*& 8_A( 1 eyelashes R8 кA(4â
Ay&, ._7 ghl , ry Ay& кHR&9(A( .

Biotin &'() : a_ &'() .&'(4r1 W. oghS «$'( 7500mcg @gк)
5000mcg R&O к) &<E. &'

CDA R8 4
CDA ry R8 @&?
CDA ghl @¨<E
7r *) 21l 9>+@9(P. \ shampoos .. biotin кHR A .&'(4r1 W,
biotin 4 Kb£&9к"# $%, GR1 *eкg

CDA *5@& &r&<E .Q 8& =&<% =Z'&
&<E .
palmo plantar Pustulosis
"«"l& *Y=(L° ) t

l Fu R8 \@Yv _
l ) ._7 9g}&, к R8 ;?g
.@8Gк) к .xXg` @к) <RM&<E. biotin 1*& ^к *a%8к"# @+&
к :@K8 derangements @OP&<E. lк{, :@K8 R8 ^к 1") . biotin
*R"A <v
Cgh W. gÎ 8_) biotin 1*& G XE R8 < Ar@& G mL
R8 *5F* 1 к)?&<E $[H8a%=L (W. Biotin O?Sк) к "#5 4Ó38 agent к
.A(4&^ .'A& к O?S *5@& M@5

CD&<E. .'A&, x# R8_ 9g}, <[3b£к
* R©[_=, .m 9g}ÉÂ < ghW A к/ ?'(*R :@K8
.xXg`?) R8 ^к *a%8к"# @+& $² biotin 1*& кHR, .&'(@A biotin O?S
"«"l& =&'g&1, G ^( O?S1 *5eя) .&<E&OA Xg& A&<E .
9g}ÉÂ (x# 4Ò gW 9g} É^ )
(PKU-phenylketonuria; к .
CD l& ª_w
3 OÈA& a%8 к ) phenylketonuria .Q
к .gh<[3A Gg=?v& :@K8 gh}? mlк) ?g9( 26L»' 9g}&, ;?g шqg g&1l $g
R8 x# 4Ò ãW 9g} @& 9g} *R¥ ? кm&9( . PKU $² *5я) =&i&a% "~ g) /0A
$²)"~ )=( @& 9g}& _ghZ) biotin *eR&9/ *¬ x¥Í =&4&XE&OA
&+@9(P. mngh?A g biotin =&'1 x# 4Ò ãW 9g}

Cgh 9>*4/0&<E .
*5@&-toxicity>
я&? .^ 8) biotin .XEк x¥W1 «$'(1 g`& \, <[3 &-, *5G) Ar
l
=>O&aW. я&?@Y) R8 _A@Y) GR "# к .@=) к&- к)@ *R_`& к=& к
g¾ ä «$'(1 ?ryF gh@YA( .&<E&9@9(P. ÜÝ@Y1l sebhorrheic 9g} <f@l
:@K8 gh}? O?S *eR&OA*YZ+, *56к *5GA( =&х GQ<E&OA =&'1,
х &, .XEк «$'(1 ¦vкR&9+& A(&/0 W.

విటమిన్ ~B7

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విటమిన్ ~B7

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B7, H, Biotin

A   "+,к)&<& !. K&' A(']R&OA O$SX)  .@]A F=& @R&OA

*5^ O?S _?5

bcd ,Vitamin H,Biotin ,4e.

l  ?8_q1 ") *&9(к)&r&<E. шqg&1 t

9g}& "~ /04gк)&/ g0=L (&<E. <f к) 25

.&a% *<) : H@, /0&OA +,l... 'w3A G1 .

H  < &я3  = 8R R . к/ m)xLgh . Biotin 1 к tetrahydrothiophene R&

кH "# W к ureido (tetrahydroimidizalone) R& *5&?& &<E. к valeric 8_

*5$ _8 tetrahydrothiophene R& к gN .`@Y к .A(=&X&94+,?&<E.

l  x#  , R8 Gw3 ?8_q1A( , к &я3  = 8R, R8

"#5 pA( , \@Yv  l  ?8_gW-'t

xXg` `(general view):

l ) ?Z6L , R8 \@Yv) R8 .

кA4+,?&<E.;<E ry  < 9g}& <v Kb£&9+& x^ & '(.

Biotin 1*& .gh'(.  g`&, .Qк <%1 9y 4'

:@gx8A9g A*Y+, biotin 1") .Qк& W.

oxopelargonic 8_ synthase к pyridoxal 5'-o ­® &я3¯. pimeloyl-CoA, xygy к

aminotransferase, NH2 <?  (AdoMet) S-adenosylmethionine *eR&O .xXg`

&<E. Dethiobiotin synthethase ATP $² 8_yG®

gZ+ $%³´g`. /0к{ к deoxyadenosyl 1 Biotin synthase reductively cleaves

7&'5& кA(A4/0&<E ;<E =­ <?, <v Oк)\ &<E.

Cofactor :@gx8A=L §&

* µ3{-CoA carboxylase _­,

* µ3{-CoA carboxylase ¶,

4y \@Yv  l& ?8_q1, х-)=( .

a%8, "#5 pA( gh8 \@Yv  l A(&/0 ?8_gWA t

= eя8  carboxylases 1 R·y w3 ¸l¹ mS1-.

7ml7 = ^ *5K8 .^ 8A& к х

=]я& FK _ я? кm=L (&<E.

Biotin 4& 1 = eя8 4& =»m&a%, 4

=>O=(L&<E)  < B7 . m)xLgh. Biotin к = _A

R8 F/0ml) 1 gvb£&O a%84/¾W.  .^ 8) A(&/0, яRRA<E biotin = _A

a_ R&я) biotin к 20-40% @gк) g`& = _A

A(&/0 biotin к = _A

Biotin 1*& к `):

* bcW Ay& (.1m 8_)

кTUV, к), gh, R8 яAQ&<E58 "5&?& 9(×

Ø gÇ*&1 9g}ÉÂA((/[g}µ3 ) @A .

xvк х Ø, кH к .xXg` х \@Yv *&m`Ù,  "biotin-1*& х&" (biotin

?R±"# WA ¥6 *56&&a% 3-hydroxyisovaleric 8_ .xXg` mngh', . *RÉ^A

9>m&O&<E. g& = 8&1  .@ш& biotin 1*&  ÜÝ@Y) '*Yryк$² @OPA

malformations(cleft palate) @9(P . GQ<E&O&<E .^ 8) $[)*Y?W .

Biotin-XR? carboxylases к 1*& 9g ) кHR Gg=?v& :@K8 1") 4]ÞT

carboxylase 1*& . m)=(Lgh.  &я3 ) holocarboxylase synthetase  <

biotinidase 1 1"A( W. Holocarboxylase synthetase 1*& = g¥ @&?& biotin

C?L4/0, tgÈ), .@¨<E = &, .1m 8_, R8 F _.

Biotinidase biocytin R8 biotinyl-mnmy nàS (*56 holocarboxylase к proteolytic

.XÕ кg`& ?Z?

 g "#5 p-G2ÅÆV biotin A(&/0 biotin L 1 к/ a_ х

R8 *)94/0A*Y+,) .¥*&яg& 1  &9@9(P . \@Yv  8& R8 t?5m&/

&/Õ5 ¯ (FLKS) R8  8  9g} $[3 K&^( G XE к/ =&i&9@9(P.

l Fu x¥WA( =v8& @, \ .^ 81 *G=& t

l Fu 8&?5` =&4&^& '(·4gh R8 я'R&9& &+,

bcW & gh = = )

Ay&, ._7 ghl , ry Ay& кHR&9(A( .

5000mcg R&O к) &<E. &'

biotin 4 Kb£&9к"# $%, GR1  *eкg

palmo plantar Pustulosis

"«"l& *Y=(L° ) t

.A(4&^ .'A& к O?S *5@& M@5

"«"l& =&'g&1, G ^( O?S1 *5eя) .&<E&OA Xg& A&<E .

9g}ÉÂ (x# 4Ò gW 9g} É^ )

&+@9(P. mngh?A  g biotin  =&'1 x# 4Ò ãW 9g}

A "+,к)&<& !. K&' A(']R&OA O$SX) .@]A F=& @R&OA

*5^ O?S _?5

bcd ,Vitamin H,Biotin ,4e.

l ?8_q1 ") *&9(к)&r&<E. шqg&1 t

9g}& "~ /04gк)&/ g0=L (&<E. <f к) 25

.&a% *<) : H@, /0&OA +,l... 'w3A G1 .

H < &я3 = 8R R . к/ m)xLgh . Biotin 1к tetrahydrothiophene R&

кH "# W к ureido (tetrahydroimidizalone) R& *5&?& &<E. к valeric 8_

*5$ _8 tetrahydrothiophene R& к gN .`@Y к .A(=&X&94+,?&<E.

l x# , R8 Gw3 ?8_q1A( , к &я3 = 8R, R8

"#5 pA( , \@Yv l ?8_gW-'t

xXg` `(general view):

l ) ?Z6L , R8 \@Yv) R8 .

кA4+,?&<E.;<E ry < 9g}& <v Kb£&9+& x^ & '(.

Biotin 1*& .gh'(. g`&, .Qк <%1 9y 4'

:@gx8A9g A*Y+, biotin 1") .Qк& W.

oxopelargonic 8_ synthase к pyridoxal 5'-o ® &я3¯. pimeloyl-CoA, xygy к

aminotransferase, NH2 <? (AdoMet) S-adenosylmethionine *eR&O .xXg`

&<E. Dethiobiotin synthethase ATP $² 8_yG®

gZ+ $%³´g`. /0к{ к deoxyadenosyl 1 Biotin synthase reductively cleaves

7&'5& кA(A4/0&<E ;<E = <?, <v Oк)\ &<E.

Cofactor :@gx8A=L §&

* µ3{-CoA carboxylase _,

* µ3{-CoA carboxylase ¶,

4y \@Yv l& ?8_q1, х-)=( .

a%8, "#5 pA( gh8 \@Yv lA(&/0 ?8_gWA t

=eя8 carboxylases 1 R·y w3 ¸l¹ mS1-.

7ml7 = ^ *5K8 .^ 8A& к х

=]я& FK_ я? кm=L (&<E.

Biotin 4& 1 =eя8 4& =»m&a%, 4

=>O=(L&<E) < B7 . m)xLgh. Biotin к =_A

R8 F/0ml) 1 gvb£&O a%84/¾W. .^ 8) A(&/0, яRRA<E biotin =_A

a_ R&я) biotin к 20-40% @gк) g`& =_A

A(&/0 biotin к =_A

Biotin 1*& к `):

* bcW Ay& (.1m 8_)

кTUV, к), gh, R8 яAQ&<E58 "5&?& 9(×

Ø gÇ*&1 9g}ÉÂA((/[g}µ3 ) @A .

xvк х Ø, кH к .xXg` х \@Yv &m`Ù, "biotin-1& х&" (biotin

?R±"# WA ¥6 56&&a% 3-hydroxyisovaleric 8_ .xXg` mngh', . RÉ^A

9>m&O&<E. g& =8&1 .@ш& biotin 1& ÜÝ@Y) 'Yryк$² @OPA

malformations(cleft palate) @9(P . GQ<E&O&<E .^ 8) $[)*Y?W .

Biotin-XR? carboxylases к 1*& 9g ) кHR Gg=?v& :@K8 1") 4]ÞT

carboxylase 1*& . m)=(Lgh. &я3) holocarboxylase synthetase <

biotinidase 1 1"A( W. Holocarboxylase synthetase 1*& =g¥ @&?& biotin

C?L4/0, tgÈ), .@¨<E = &, .1m 8_, R8 F_.

Biotinidase biocytin R8 biotinyl-mnmy nàS (*56 holocarboxylase к proteolytic

.XÕ кg`& ?Z?

g "#5 p-G2ÅÆV biotin A(&/0 biotin L 1 к/ a_ х

R8 )94/0AY+,) .¥*&яg& 1 &9@9(P . \@Yv 8& R8 t?5m&/

&/Õ5 ¯ (FLKS) R8 8 9g} $[3 K&^( G XE к/ =&i&9@9(P.

l Fu x¥WA( =v8& @, \ .^ 81 *G=& t

l Fu 8&?5` =&4&^& '(·4gh R8 я'R&9& &+,

bcW & gh == )

Ay&, ._7 ghl , ry Ay& кHR&9(A( .

5000mcg R&O к) &<E. &'

biotin 4 Kb£&9к"# $%, GR1 *eкg

"«"l& *Y=(L° ) t

.A(4&^ .'A& к O?S *5@& M@5

"«"l& =&'g&1, G ^( O?S1 *5eя) .&<E&OA Xg& A&<E .

9g}ÉÂ (x# 4Ò gW 9g} É^ )

&+@9(P. mngh?A g biotin =&'1 x# 4Ò ãW 9g}

g¾ ä «$'(1 ?ryF gh@YA( .&<E&9@9(P. ÜÝ@Y1l sebhorrheic 9g} <f@l

:@K8 gh}? O?S eR&OAYZ+, 56к 5GA( =&х GQ<E&OA =&'1,

х &, .XEк «$'(1 ¦vкR&9+& A(&/0 W.