Organ dysfunction

Organ dysfunction is a condition where an organ does not perform its expected function. Organ failure is
organ dysfunction to such a degree that normal homeostasis cannot be maintained without external clinical
intervention.

It is not a diagnosis. It can be classified by the cause, but when the cause is not known, it can also be
classified by whether the onset is chronic or acute.

Multiple organ failure can be associated with sepsis and is often fatal. Countries such as Spain, have shown
a rise in mortality risk, due to a large elderly population there.[1]

However, there are tools physicians use when diagnosing multiple organ failure and when prognosing the
outcome. The Sequential Organ Failure Assessment (SOFA) score[2] uses early lab values in a patient's
hospitalization (within 24 hours) to predict fatal outcomes for a patient.

References
1. Bouza C, López-Cuadrado T, Saz-Parkinson Z, Blanco J (2014). "Epidemiology and recent
trends of severe sepsis in Spain: a nationwide population-based analysis (2006-2011)" (http
s://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327809). BMC Infect Dis. 14 (1): 717.
doi:10.1186/s12879-014-0717-7 (https://doi.org/10.1186%2Fs12879-014-0717-7).
PMC 4327809 (https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4327809). PMID 25528662
(https://pubmed.ncbi.nlm.nih.gov/25528662).
2. Ferreira FL, Bota DP, Bross A, Mélot C, Vincent JL (2001). "Serial evaluation of the SOFA
score to predict outcome in critically ill patients" (https://doi.org/10.1001%2Fjama.286.14.17
54). JAMA. 286 (14): 1754–8. doi:10.1001/jama.286.14.1754 (https://doi.org/10.1001%2Fja
ma.286.14.1754). PMID 11594901 (https://pubmed.ncbi.nlm.nih.gov/11594901).

External links
Sequential Organ Failure Assessment (SOFA) Score (http://www.mdcalc.com/sequential-org
an-failure-assessment-sofa-score/)

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This page was last edited on 26 June 2021, at 13:46 (UTC).

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