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10 Interactions Found

See details below.

Patient Regimen

  aspirin
• acetylsalicylic acid

  clopidogrel

  captopril

  sodium bicarbonate

  folic acid

  ranitidine

  heparin

Serious - Use Alternative

aspirin + captopril

aspirin, captopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug.

Coadministration may result in a significant decrease in renal function. NSAIDs may diminish
the antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely
related to the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

Monitor Closely

aspirin + clopidogrel

aspirin, clopidogrel.
Either increases toxicity of the other by pharmacodynamic synergism.
Use Caution/Monitor. The need for simultaneous use of low-dose aspirin and anticoagulant or
antiplatelet agents are common for patients with cardiovascular disease; monitor closely.

sodium bicarbonate + captopril

sodium bicarbonate decreases effects of captopril by unspecified interaction mechanism. Use

Caution/Monitor. Sodium bicarbonate may decrease absorption of captopril.

captopril + aspirin

captopril, aspirin.
Either increases toxicity of the other by Other (see comment). Use
Caution/Monitor. Comment: May result in renal function deterioration, particularly with high
dose aspirin, elderly or volume depleted individuals.

aspirin + heparin
 aspirin, heparin.
Either increases toxicity of the other by anticoagulation. Use
Caution/Monitor. The need for simultaneous use of low-dose aspirin and anticoagulant or
antiplatelet agents are common for patients with cardiovascular disease; monitor closely.

heparin + captopril

heparin increases toxicity of captopril by Other (see comment). Use Caution/Monitor.

Comment: Low molecular weight heparins may suppress adrenal aldosterone secretion,
which can potentially cause hyperkalemia.

heparin + aspirin

heparin and aspirin both increase anticoagulation. Modify Therapy/Monitor Closely.

heparin + clopidogrel

heparin, clopidogrel.
Either increases effects of the other by pharmacodynamic synergism.
Modify Therapy/Monitor Closely. Enhanced risk of hemorrhage; additive effects are intended
when both drugs are prescribed as indicated for ACS.

Minor

sodium bicarbonate + aspirin

sodium bicarbonate, aspirin. Mechanism: passive renal tubular reabsorption due to increased
pH. Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate
levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).

aspirin + folic acid

aspirin decreases levels of folic acid by inhibition of GI absorption. Applies only to oral form of
both agents. Minor/Significance Unknown.

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