4/3/24, 14:07 Drug Interactions Checker - Medscape Drug Reference Database

This site is intended for healthcare professionals

281 Interactions Found

See details below.

Patient Regimen

amlodipine

captopril

enoxaparin

losartan

omeprazole

acetaminophen IV

pregabalin

metoclopramide

acetazolamide

aspirin
• acetylsalicylic acid

heparin

folic acid

tranexamic acid injection

valproic acid

zoledronic acid

albumin IV

allopurinol

amphotericin B deoxycholate
• amphotericin B (conventional)

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amikacin

amiodarone

amitriptyline

ampicillin

ampicillin/sulbactam

aripiprazole

atenolol

atorvastatin

atropine IV/IM

azathioprine

azithromycin

baclofen

calcipotriene/betamethasone

budesonide

buprenorphine
• Buprenex

calcium carbonate

carbamazepine

carvedilol

cefadroxil

celecoxib

clonidine

clopidogrel

clobetasone

clozapine

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chlorpheniramine

chloral hydrate

sodium sulfate/​magnesium sulfate/potassium chloride

chlorpheniramine/pseudoephedrine
• A.R.M.

dexamethasone

donepezil

chlordiazepoxide/ clidinium

Contraindicated

amikacin + amphotericin B deoxycholate

amikacin and amphotericin B deoxycholate both increase nephrotoxicity and/or ototoxicity.

Contraindicated.

Serious - Use Alternative

aspirin + captopril

aspirin, captopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug. Coadministration

may result in a significant decrease in renal function. NSAIDs may diminish the antihypertensive
effect of ACE inhibitors. The mechanism of these interactions is likely related to the ability of
NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

celecoxib + captopril

celecoxib, captopril. pharmacodynamic antagonism. Avoid or Use Alternate Drug.

Coadministration may result in a significant decrease in renal function. NSAIDs may diminish the
antihypertensive effect of ACE inhibitors. The mechanism of these interactions is likely related to
the ability of NSAIDs to reduce the synthesis of vasodilating renal prostaglandins.

atenolol + carvedilol

atenolol and carvedilol both increase anti-hypertensive channel blocking. Avoid or Use Alternate
Drug.

enoxaparin + heparin

enoxaparin and heparin both increase anticoagulation. Avoid or Use Alternate Drug.

omeprazole + clopidogrel

omeprazole decreases effects of clopidogrel by affecting hepatic enzyme CYP2C19 metabolism.

Avoid or Use Alternate Drug. Clopidogrel efficacy may be reduced by drugs that inhibit

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CYP2C19. Inhibition of platelet aggregation by clopidogrel is entirely due to an active metabolite.

Clopidogrel is metabolized to this active metabolite in part by CYP2C19. .

carbamazepine + losartan

carbamazepine will decrease the level or effect of losartan by affecting hepatic/intestinal enzyme
CYP3A4 metabolism. Avoid or Use Alternate Drug.

aripiprazole + amiodarone

aripiprazole and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.

clozapine + amiodarone

clozapine and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.

donepezil + amiodarone

donepezil and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.

buprenorphine + amiodarone

buprenorphine and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.

donepezil + azithromycin

donepezil and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.

donepezil + buprenorphine

donepezil and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.

buprenorphine + amitriptyline

buprenorphine and amitriptyline both increase QTc interval. Avoid or Use Alternate Drug.

buprenorphine + azithromycin

buprenorphine and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.

clozapine + azithromycin

clozapine and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.

clozapine + buprenorphine

clozapine and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.

aripiprazole + azithromycin

aripiprazole and azithromycin both increase QTc interval. Avoid or Use Alternate Drug.

aripiprazole + clozapine

aripiprazole and clozapine both increase QTc interval. Avoid or Use Alternate Drug.

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aripiprazole + buprenorphine

aripiprazole and buprenorphine both increase QTc interval. Avoid or Use Alternate Drug.

captopril + allopurinol

captopril increases toxicity of allopurinol by Mechanism: unspecified interaction mechanism.

Avoid or Use Alternate Drug. May increase risk for allergic or hypersensitivity reactions to
allopurinol Monitor for symptoms of hypersensitivty reactions if both drugs must be used
together.

carbamazepine + clozapine

carbamazepine, clozapine. Either increases toxicity of the other by pharmacodynamic

synergism. Avoid or Use Alternate Drug. Increased risk of agranulocytosis.

allopurinol + azathioprine

allopurinol increases levels of azathioprine by decreasing metabolism. Avoid or Use Alternate

Drug. Increased risk of bone marrow toxicity.

losartan + captopril

losartan, captopril. Either increases toxicity of the other by pharmacodynamic synergism. Avoid
or Use Alternate Drug. Dual blockade of renin-angiotensin system increases risks of
hypotension, hyperkalemia, and renal impairment.

carbamazepine + omeprazole

carbamazepine will decrease the level or effect of omeprazole by affecting hepatic enzyme
CYP2C19 metabolism. Avoid or Use Alternate Drug.

clonidine + atenolol

clonidine, atenolol. Either increases toxicity of the other by unspecified interaction mechanism.
Avoid or Use Alternate Drug. Can increase risk of bradycardia.

captopril + pregabalin

captopril, pregabalin. Either increases toxicity of the other by Other (see comment). Avoid or Use
Alternate Drug. Comment: Coadministration results in additive risk of developing angioedema of
face, mouth, and neck. Angioedema may result in respiratory compromise.

clonidine + buprenorphine

clonidine, buprenorphine. Either increases toxicity of the other by pharmacodynamic synergism.

Avoid or Use Alternate Drug. Coadministration enhances CNS depressant effects.

amitriptyline + pseudoephedrine

amitriptyline increases effects of pseudoephedrine by sympathetic (adrenergic) effects, including

increased blood pressure and heart rate. Avoid or Use Alternate Drug. Tricyclic antidepressants
increase or decrease effects of sympathomimetics, by blocking reuptake of NE, or blocking
uptake of indirect sympathomimetics into the adrenergic neuron.

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amitriptyline + amiodarone

amitriptyline and amiodarone both increase QTc interval. Avoid or Use Alternate Drug.

carbamazepine + budesonide

carbamazepine will decrease the level or effect of budesonide by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.

carbamazepine + dexamethasone

carbamazepine will decrease the level or effect of dexamethasone by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.

carbamazepine + amiodarone

carbamazepine will decrease the level or effect of amiodarone by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.

carbamazepine + aripiprazole

carbamazepine will decrease the level or effect of aripiprazole by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. If carbamazepine is started in a
patient already taking aripiprazole, the aripiprazole dose should be doubled; reduce aripiprazole
dose if carbamazepine is discontinued

carbamazepine + atorvastatin

carbamazepine will decrease the level or effect of atorvastatin by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.

carbamazepine + clopidogrel

carbamazepine will increase the level or effect of clopidogrel by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug. CYP3A4 inducers may increase the
metabolism of clopidogrel to its active metabolite. Monitor patients for potential increase in
antiplatelet effects when CYP3A4 inducers are used in combination with clopidogrel

carbamazepine + clozapine

carbamazepine will decrease the level or effect of clozapine by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Avoid or Use Alternate Drug.

amitriptyline + clonidine

amitriptyline decreases effects of clonidine by Other (see comment). Avoid or Use Alternate
Drug. Comment: Inhibition of uptake by adrenergic neurons.

azithromycin + enoxaparin

azithromycin increases effects of enoxaparin by decreasing metabolism. Avoid or Use Alternate

Drug.

azithromycin + heparin

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azithromycin increases effects of heparin by decreasing metabolism. Avoid or Use Alternate

Drug.

captopril + allopurinol

captopril, allopurinol. Mechanism: unknown. Avoid or Use Alternate Drug. Risk of anaphylaxis,
Stevens Johnson syndrome.

Monitor Closely

calcium carbonate + atenolol

calcium carbonate decreases effects of atenolol by unspecified interaction mechanism. Use

Caution/Monitor.

calcium carbonate + carvedilol

calcium carbonate decreases effects of carvedilol by unspecified interaction mechanism. Use

Caution/Monitor.

acetazolamide + aspirin

acetazolamide, aspirin. Either increases levels of the other by Other (see comment). Use
Caution/Monitor. Comment: Carbonic anhydrase inhibitors (CAIs) and salicylates inhibit each
other's renal tubular secretion, resulting in increased plasma levels. CAIs also shift salicylates
from plasma to the CNS, leading to potential neurotoxicity.

amiodarone + atenolol

amiodarone, atenolol. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of

cardiotoxicity with bradycardia.

amiodarone + carvedilol

amiodarone, carvedilol. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of

cardiotoxicity with bradycardia.

budesonide + enoxaparin

budesonide, enoxaparin. Other (see comment). Use Caution/Monitor. Comment: Corticosteroids

may decrease anticoagulant effects by increasing blood coagulability; conversely, they may
impair vascular integrity, thus increasing bleeding risk. Monitor INR closely.

budesonide + heparin

budesonide, heparin. Other (see comment). Use Caution/Monitor. Comment: Corticosteroids

may decrease anticoagulant effects by increasing blood coagulability; conversely, they may
impair vascular integrity, thus increasing bleeding risk. Monitor INR closely.

dexamethasone + enoxaparin

dexamethasone, enoxaparin. Other (see comment). Use Caution/Monitor. Comment:

Corticosteroids may decrease anticoagulant effects by increasing blood coagulability;
conversely, they may impair vascular integrity, thus increasing bleeding risk. Monitor INR closely.

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dexamethasone + heparin

dexamethasone, heparin. Other (see comment). Use Caution/Monitor. Comment: Corticosteroids

may decrease anticoagulant effects by increasing blood coagulability; conversely, they may
impair vascular integrity, thus increasing bleeding risk. Monitor INR closely.

calcium carbonate + zoledronic acid

calcium carbonate decreases levels of zoledronic acid by inhibition of GI absorption. Applies only
to oral form of both agents. Use Caution/Monitor. Separate by 30 minutes.

clonidine + aripiprazole

clonidine, aripiprazole. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Additive

hypotensive effects; potential delirium.

clonidine + clozapine

clonidine, clozapine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Additive

hypotensive effects; potential delirium.

aspirin + dexamethasone

aspirin, dexamethasone. Either increases toxicity of the other by pharmacodynamic synergism.

Use Caution/Monitor. Increased risk of GI ulceration.

celecoxib + budesonide

celecoxib, budesonide. Either increases toxicity of the other by pharmacodynamic synergism.

Use Caution/Monitor. Increased risk of GI ulceration.

celecoxib + dexamethasone

celecoxib, dexamethasone. Either increases toxicity of the other by pharmacodynamic

synergism. Use Caution/Monitor. Increased risk of GI ulceration.

valproic acid + carbamazepine

valproic acid will increase the level or effect of carbamazepine by Mechanism: decreasing
metabolism. Use Caution/Monitor. Valproic acid may increase or decrease carbamazepine
levels.

atenolol + losartan

atenolol, losartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of fetal

compromise if given during pregnancy.

carvedilol + losartan

carvedilol, losartan. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of

fetal compromise if given during pregnancy.

ampicillin + aspirin

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ampicillin, aspirin. Either increases levels of the other by plasma protein binding competition.
Use Caution/Monitor.

carbamazepine + valproic acid

carbamazepine decreases levels of valproic acid by increasing metabolism. Use

Caution/Monitor.

calcium carbonate + allopurinol

calcium carbonate decreases levels of allopurinol by inhibition of GI absorption. Applies only to

oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

carbamazepine + enoxaparin

carbamazepine decreases levels of enoxaparin by increasing metabolism. Use Caution/Monitor.

carbamazepine + heparin

carbamazepine decreases levels of heparin by increasing metabolism. Use Caution/Monitor.

calcium carbonate + atenolol

calcium carbonate decreases levels of atenolol by inhibition of GI absorption. Applies only to oral
form of both agents. Use Caution/Monitor. Separate by 2 hours.

calcium carbonate + amlodipine

calcium carbonate decreases effects of amlodipine by pharmacodynamic antagonism. Use

Caution/Monitor.

acetazolamide + aspirin

acetazolamide, aspirin. Mechanism: passive renal tubular reabsorption due to increased pH. Use
Caution/Monitor. Salicylate levels increased at moderate doses; risk of CNS toxicity. Salicylate
levels decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).

azathioprine + enoxaparin

azathioprine decreases effects of enoxaparin by unknown mechanism. Use Caution/Monitor.

azathioprine + heparin

azathioprine decreases effects of heparin by unknown mechanism. Use Caution/Monitor.

calcium carbonate + carvedilol

calcium carbonate decreases levels of carvedilol by inhibition of GI absorption. Applies only to

oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

aspirin + valproic acid

aspirin increases levels of valproic acid by plasma protein binding competition. Use
Caution/Monitor.

aspirin + clopidogrel
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aspirin, clopidogrel. Either increases toxicity of the other by pharmacodynamic synergism. Use
Caution/Monitor. The need for simultaneous use of low-dose aspirin and anticoagulant or
antiplatelet agents are common for patients with cardiovascular disease; monitor closely.

calcium carbonate + azithromycin

calcium carbonate decreases levels of azithromycin by inhibition of GI absorption. Applies only to

oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

captopril + azathioprine

captopril, azathioprine. Mechanism: pharmacodynamic synergism. Use Caution/Monitor. Risk of

neutropenia.

aspirin + atenolol

aspirin decreases effects of atenolol by pharmacodynamic antagonism. Use Caution/Monitor.

Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

aspirin + carvedilol

aspirin decreases effects of carvedilol by pharmacodynamic antagonism. Use Caution/Monitor.

Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

celecoxib + atenolol

celecoxib decreases effects of atenolol by pharmacodynamic antagonism. Use Caution/Monitor.

Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

celecoxib + carvedilol

celecoxib decreases effects of carvedilol by pharmacodynamic antagonism. Use

Caution/Monitor. Long term (>1 wk) NSAID use. NSAIDs decrease prostaglandin synthesis.

budesonide + aripiprazole

budesonide will decrease the level or effect of aripiprazole by affecting hepatic/intestinal enzyme
CYP3A4 metabolism. Use Caution/Monitor.

budesonide + carbamazepine

budesonide will decrease the level or effect of carbamazepine by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Use Caution/Monitor.

budesonide + clopidogrel

budesonide will increase the level or effect of clopidogrel by affecting hepatic/intestinal enzyme
CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers may increase the metabolism of
clopidogrel to its active metabolite. Monitor patients for potential increase in antiplatelet effects
when CYP3A4 inducers are used in combination with clopidogrel

budesonide + clozapine

budesonide will decrease the level or effect of clozapine by affecting hepatic/intestinal enzyme
CYP3A4 metabolism. Use Caution/Monitor.

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dexamethasone + aripiprazole

dexamethasone will decrease the level or effect of aripiprazole by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Use Caution/Monitor.

dexamethasone + atorvastatin

dexamethasone will decrease the level or effect of atorvastatin by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Use Caution/Monitor.

dexamethasone + carbamazepine

dexamethasone will decrease the level or effect of carbamazepine by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Use Caution/Monitor.

dexamethasone + clopidogrel

dexamethasone will increase the level or effect of clopidogrel by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Use Caution/Monitor. CYP3A4 inducers may increase the
metabolism of clopidogrel to its active metabolite. Monitor patients for potential increase in
antiplatelet effects when CYP3A4 inducers are used in combination with clopidogrel

dexamethasone + clozapine

dexamethasone will decrease the level or effect of clozapine by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Use Caution/Monitor.

carbamazepine + clozapine

carbamazepine will decrease the level or effect of clozapine by affecting hepatic enzyme
CYP1A2 metabolism. Use Caution/Monitor.

amiodarone + carvedilol

amiodarone will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10
metabolism. Use Caution/Monitor.

amiodarone + losartan

amiodarone will increase the level or effect of losartan by affecting hepatic enzyme CYP2C9/10
metabolism. Use Caution/Monitor. May inhibit the conversion of losartan to its active metabolite
E-3174. Importance of interaction not established; monitor individual therapeutic response to
determine losartan dosage.

omeprazole + losartan

omeprazole will increase the level or effect of losartan by affecting hepatic enzyme CYP2C9/10
metabolism. Use Caution/Monitor. May inhibit the conversion of losartan to its active metabolite
E-3174. Importance of interaction not established; monitor individual therapeutic response to
determine losartan dosage.

valproic acid + carvedilol

valproic acid will increase the level or effect of carvedilol by affecting hepatic enzyme
CYP2C9/10 metabolism. Use Caution/Monitor.

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carbamazepine + carvedilol

carbamazepine will decrease the level or effect of carvedilol by affecting hepatic enzyme
CYP2C9/10 metabolism. Use Caution/Monitor.

carbamazepine + losartan

carbamazepine will decrease the level or effect of losartan by affecting hepatic enzyme
CYP2C9/10 metabolism. Use Caution/Monitor.

amiodarone + carvedilol

amiodarone will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6
metabolism. Use Caution/Monitor. Monitor for signs of bradycardia or heart block when
amiodarone and a beta adrenergic blocker are coadministered. Amiodarone should be used with
caution in patients receiving a beta adrenergic blocker, particularly if there is suspicion of
underlying dysfunction of the sinus node, such as bradycardia or sick sinus syndrome, or if there
is partial AV block.

celecoxib + carvedilol

celecoxib will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2D6
metabolism. Use Caution/Monitor.

budesonide + dexamethasone

budesonide will decrease the level or effect of dexamethasone by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Use Caution/Monitor.

budesonide + amiodarone

budesonide will decrease the level or effect of amiodarone by affecting hepatic/intestinal enzyme
CYP3A4 metabolism. Use Caution/Monitor.

enoxaparin + aspirin

enoxaparin and aspirin both increase anticoagulation. Use Caution/Monitor. Additive effects are
intended when both drugs are prescribed as indicated for unstable angina, non-Q-wave MI, and
STEMI

dexamethasone + amiodarone

dexamethasone will decrease the level or effect of amiodarone by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Use Caution/Monitor.

amiodarone + amikacin

amiodarone will increase the level or effect of amikacin by P-glycoprotein (MDR1) efflux
transporter. Use Caution/Monitor.

amiodarone + budesonide

amiodarone will increase the level or effect of budesonide by P-glycoprotein (MDR1) efflux
transporter. Use Caution/Monitor.

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amiodarone + dexamethasone

amiodarone will increase the level or effect of dexamethasone by P-glycoprotein (MDR1) efflux
transporter. Use Caution/Monitor.

amiodarone + amitriptyline

amiodarone will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux
transporter. Use Caution/Monitor.

amiodarone + atorvastatin

amiodarone will increase the level or effect of atorvastatin by P-glycoprotein (MDR1) efflux
transporter. Use Caution/Monitor.

atorvastatin + budesonide

atorvastatin will increase the level or effect of budesonide by P-glycoprotein (MDR1) efflux
transporter. Use Caution/Monitor.

atorvastatin + dexamethasone

atorvastatin will increase the level or effect of dexamethasone by P-glycoprotein (MDR1) efflux
transporter. Use Caution/Monitor.

atorvastatin + amitriptyline

atorvastatin will increase the level or effect of amitriptyline by P-glycoprotein (MDR1) efflux
transporter. Use Caution/Monitor.

acetazolamide + pseudoephedrine

acetazolamide will increase the level or effect of pseudoephedrine by passive renal tubular
reabsorption - basic urine. Use Caution/Monitor.

sodium sulfate/?magnesium sulfate/potassium chloride + losartan

sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of losartan by Other

(see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause
fluid and electrolyte abnormalities may increase the risk of adverse events of seizure,
arrhythmias, and renal impairment.

sodium sulfate/?magnesium sulfate/potassium chloride + captopril

sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of captopril by Other

(see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause
fluid and electrolyte abnormalities may increase the risk of adverse events of seizure,
arrhythmias, and renal impairment.

sodium sulfate/?magnesium sulfate/potassium chloride + aspirin

sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of aspirin by Other

(see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause
fluid and electrolyte abnormalities may increase the risk of adverse events of seizure,
arrhythmias, and renal impairment.

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sodium sulfate/?magnesium sulfate/potassium chloride + celecoxib

sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of celecoxib by Other

(see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause
fluid and electrolyte abnormalities may increase the risk of adverse events of seizure,
arrhythmias, and renal impairment.

sodium sulfate/?magnesium sulfate/potassium chloride + betamethasone

sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of betamethasone by

Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that
cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure,
arrhythmias, and renal impairment.

sodium sulfate/?magnesium sulfate/potassium chloride + dexamethasone

sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of dexamethasone by

Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that
cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure,
arrhythmias, and renal impairment.

sodium sulfate/?magnesium sulfate/potassium chloride + amikacin

sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of amikacin by Other

(see comment). Use Caution/Monitor. Comment: Coadministration with medications that cause
fluid and electrolyte abnormalities may increase the risk of adverse events of seizure,
arrhythmias, and renal impairment.

sodium sulfate/?magnesium sulfate/potassium chloride + calcium carbonate

sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of calcium carbonate

by Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications
that cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure,
arrhythmias, and renal impairment.

sodium sulfate/?magnesium sulfate/potassium chloride + zoledronic acid

sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of zoledronic acid by

Other (see comment). Use Caution/Monitor. Comment: Coadministration with medications that
cause fluid and electrolyte abnormalities may increase the risk of adverse events of seizure,
arrhythmias, and renal impairment.

sodium sulfate/?magnesium sulfate/potassium chloride + amphotericin B deoxycholate

sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of amphotericin B

deoxycholate by Other (see comment). Use Caution/Monitor. Comment: Coadministration with
medications that cause fluid and electrolyte abnormalities may increase the risk of adverse
events of seizure, arrhythmias, and renal impairment.

sodium sulfate/?magnesium sulfate/potassium chloride + amiodarone

sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of amiodarone by QTc

interval. Use Caution/Monitor. Consider predose and post-colonoscopy ECGs in patients at
increased risk of serious cardiac arrhythmias.

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sodium sulfate/?magnesium sulfate/potassium chloride + buprenorphine

sodium sulfate/?magnesium sulfate/potassium chloride increases toxicity of buprenorphine by

QTc interval. Use Caution/Monitor. Consider predose and post-colonoscopy ECGs in patients at
increased risk of serious cardiac arrhythmias.

amlodipine + sodium sulfate/?magnesium sulfate/potassium chloride

amlodipine, sodium sulfate/?magnesium sulfate/potassium chloride. Either increases effects of

the other by unknown mechanism. Use Caution/Monitor. Monitor for hypotension or muscle
weakness in patients receiving calcium channel blockers with elevated serum magnesium
concentrations.

sodium sulfate/?magnesium sulfate/potassium chloride + aripiprazole

sodium sulfate/?magnesium sulfate/potassium chloride increases effects of aripiprazole by

unknown mechanism. Use Caution/Monitor. Closely monitor for evidence of enhanced CNS
depression when using higher dose of magnesium sulfate together with a CNS depressant.

sodium sulfate/?magnesium sulfate/potassium chloride + clozapine

sodium sulfate/?magnesium sulfate/potassium chloride increases effects of clozapine by

unknown mechanism. Use Caution/Monitor. Closely monitor for evidence of enhanced CNS
depression when using higher dose of magnesium sulfate together with a CNS depressant.

sodium sulfate/?magnesium sulfate/potassium chloride + amitriptyline

sodium sulfate/?magnesium sulfate/potassium chloride increases effects of amitriptyline by

unknown mechanism. Use Caution/Monitor. Closely monitor for evidence of seizures when using
higher dose of magnesium sulfate together with drugs that lower the seizure threshold.

azithromycin + amiodarone

azithromycin will increase the level or effect of amiodarone by P-glycoprotein (MDR1) efflux
transporter. Use Caution/Monitor.

azithromycin + atorvastatin

azithromycin will increase the level or effect of atorvastatin by affecting hepatic/intestinal enzyme
CYP3A4 metabolism. Use Caution/Monitor. If this combination is used, closely monitor for
evidence of atorvastatin toxicity (eg, muscle aches or pains, renal dysfunction).

atenolol + amlodipine

atenolol, amlodipine. Either increases effects of the other by pharmacodynamic synergism. Use
Caution/Monitor. Both drugs lower blood pressure.

carbamazepine + buprenorphine

carbamazepine will decrease the level or effect of buprenorphine by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Use Caution/Monitor.

dexamethasone + buprenorphine

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dexamethasone will decrease the level or effect of buprenorphine by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Use Caution/Monitor.

carbamazepine + atorvastatin

carbamazepine increases toxicity of atorvastatin by Other (see comment). Use Caution/Monitor.

Comment: OATP1B1 inhibitors may increase risk of myopathy.

heparin + losartan

heparin increases toxicity of losartan by Other (see comment). Use Caution/Monitor. Comment:
Low molecular weight heparins may suppress adrenal aldosterone secretion, which can
potentially cause hyperkalemia.

heparin + captopril

heparin increases toxicity of captopril by Other (see comment). Use Caution/Monitor. Comment:
Low molecular weight heparins may suppress adrenal aldosterone secretion, which can
potentially cause hyperkalemia.

enoxaparin + captopril

enoxaparin increases toxicity of captopril by Other (see comment). Use Caution/Monitor.

Comment: Low molecular weight heparins may suppress adrenal aldosterone secretion, which
can potentially cause hyperkalemia.

enoxaparin + losartan

enoxaparin increases toxicity of losartan by Other (see comment). Use Caution/Monitor.

Comment: Low molecular weight heparins may suppress adrenal aldosterone secretion, which
can potentially cause hyperkalemia.

captopril + aspirin

captopril, aspirin. Either increases toxicity of the other by Other (see comment). Use
Caution/Monitor. Comment: May result in renal function deterioration, particularly with high dose
aspirin, elderly or volume depleted individuals.

captopril + celecoxib

captopril, celecoxib. Either increases toxicity of the other by Other (see comment). Use
Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or
volume depleted individuals.

losartan + aspirin

losartan, aspirin. Either increases toxicity of the other by Other (see comment). Use
Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or
volume depleted individuals.

losartan + celecoxib

losartan, celecoxib. Either increases toxicity of the other by Other (see comment). Use
Caution/Monitor. Comment: May result in renal function deterioration, particularly in elderly or
volume depleted individuals.

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aspirin + enoxaparin

aspirin, enoxaparin. Either increases toxicity of the other by pharmacodynamic synergism. Use
Caution/Monitor. The need for simultaneous use of low-dose aspirin and anticoagulant or
antiplatelet agents are common for patients with cardiovascular disease; monitor closely.

aspirin + heparin

aspirin, heparin. Either increases toxicity of the other by anticoagulation. Use Caution/Monitor.
The need for simultaneous use of low-dose aspirin and anticoagulant or antiplatelet agents are
common for patients with cardiovascular disease; monitor closely.

aripiprazole + atropine IV/IM

aripiprazole increases effects of atropine IV/IM by pharmacodynamic synergism. Use

Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

clozapine + atropine IV/IM

clozapine increases effects of atropine IV/IM by pharmacodynamic synergism. Use

Caution/Monitor. Additive anticholinergic effects, possible hypoglycemia.

atropine IV/IM + aripiprazole

atropine IV/IM decreases levels of aripiprazole by inhibition of GI absorption. Applies only to oral
form of both agents. Use Caution/Monitor.

atropine IV/IM + aripiprazole

atropine IV/IM decreases levels of aripiprazole by pharmacodynamic antagonism. Use

Caution/Monitor.

atropine IV/IM + clozapine

atropine IV/IM decreases levels of clozapine by inhibition of GI absorption. Applies only to oral
form of both agents. Use Caution/Monitor.

atropine IV/IM + clozapine

atropine IV/IM decreases levels of clozapine by pharmacodynamic antagonism. Use

Caution/Monitor.

calcium carbonate + captopril

calcium carbonate decreases effects of captopril by unspecified interaction mechanism. Use

Caution/Monitor. Calcium carbonate may decrease absorption of captopril.

calcium carbonate + celecoxib

calcium carbonate decreases levels of celecoxib by inhibition of GI absorption. Applies only to

oral form of both agents. Use Caution/Monitor. Separate by 2 hours.

amiodarone + captopril

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amiodarone, captopril. Either increases effects of the other by pharmacodynamic synergism.

Use Caution/Monitor. Both drugs lower blood pressure. Monitor blood pressure.

amphotericin B deoxycholate + captopril

amphotericin B deoxycholate, captopril. Either increases effects of the other by

pharmacodynamic synergism. Use Caution/Monitor. Both drugs lower blood pressure. Monitor
blood pressure.

clozapine + captopril

clozapine increases toxicity of captopril by pharmacodynamic synergism. Use Caution/Monitor.

Both drugs lower blood pressure. Monitor blood pressure.

clonidine + amiodarone

clonidine, amiodarone. Either decreases effects of the other by pharmacodynamic synergism.

Use Caution/Monitor. Coadministration increases risk of bradycardia, sinus arrest, and AV block;
monitor heart rate in patients on concomitant drugs that slow heart rate.

carbamazepine + omeprazole

carbamazepine will decrease the level or effect of omeprazole by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Use Caution/Monitor.

clonidine + atenolol

clonidine, atenolol. Either increases toxicity of the other by pharmacodynamic synergism. Use
Caution/Monitor. Sympatholytic action may worsen sinus node dysfunction and atrioventricular
(AV) block.

aripiprazole + captopril

aripiprazole, captopril. Either increases effects of the other by pharmacodynamic synergism. Use
Caution/Monitor. Both drugs lower blood pressure. Monitor blood pressure.

aripiprazole + amitriptyline

aripiprazole and amitriptyline both increase QTc interval. Use Caution/Monitor.

clozapine + amitriptyline

clozapine and amitriptyline both increase QTc interval. Use Caution/Monitor.

donepezil + aripiprazole

donepezil and aripiprazole both increase QTc interval. Use Caution/Monitor.

donepezil + amitriptyline

donepezil and amitriptyline both increase QTc interval. Use Caution/Monitor.

cefadroxil + amikacin

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cefadroxil increases toxicity of amikacin by nephrotoxicity and/or ototoxicity. Use

Caution/Monitor. Cephalosporins may increase nephrotoxic effect of aminoglycosides. .

enoxaparin + clopidogrel

enoxaparin, clopidogrel. Either increases effects of the other by pharmacodynamic synergism.

Modify Therapy/Monitor Closely. Enhanced risk of hemorrhage; additive effects are intended
when both drugs are prescribed as indicated for ACS.

heparin + clopidogrel

heparin, clopidogrel. Either increases effects of the other by pharmacodynamic synergism.

Modify Therapy/Monitor Closely. Enhanced risk of hemorrhage; additive effects are intended
when both drugs are prescribed as indicated for ACS.

aspirin + losartan

aspirin decreases effects of losartan by pharmacodynamic antagonism. Modify Therapy/Monitor

Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and thus affect fluid
homeostasis and may diminish antihypertensive effect.

celecoxib + losartan

celecoxib decreases effects of losartan by pharmacodynamic antagonism. Modify

Therapy/Monitor Closely. NSAIDs decrease synthesis of vasodilating renal prostaglandins, and
thus affect fluid homeostasis and may diminish antihypertensive effect.

clopidogrel + celecoxib

clopidogrel, celecoxib. Either increases effects of the other by pharmacodynamic synergism.

Modify Therapy/Monitor Closely. Clopidogrel and NSAIDs both inhibit platelet aggregation.

omeprazole + budesonide

omeprazole decreases effects of budesonide by increasing gastric pH. Applies only to oral form
of both agents. Modify Therapy/Monitor Closely. Enteric-coated budesonide dissolves at pH
>5.5. Also, dissolution of extended-release budesonide tablets is pH dependent.
Coadministration with drugs that increase gastric pH may cause these budesonide products to
prematurely dissolve, and possibly affect release properties and absorption of the drug in the
duodenum.

calcium carbonate + budesonide

calcium carbonate decreases effects of budesonide by increasing gastric pH. Applies only to oral
form of both agents. Modify Therapy/Monitor Closely. Enteric-coated budesonide dissolves at pH
>5.5. Also, dissolution of extended-release budesonide tablets is pH dependent.
Coadministration with drugs that increase gastric pH may cause these budesonide products to
prematurely dissolve, and possibly affect release properties and absorption of the drug in the
duodenum.

pregabalin + buprenorphine

pregabalin, buprenorphine. Either increases effects of the other by pharmacodynamic

synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in

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serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor
for respiratory depression and sedation.

pregabalin + chlorpheniramine

pregabalin, chlorpheniramine. Either increases effects of the other by pharmacodynamic

synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in
serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor
for respiratory depression and sedation.

pregabalin + chloral hydrate

pregabalin, chloral hydrate. Either increases effects of the other by pharmacodynamic

synergism. Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in
serious, life-threatening, and fatal respiratory depression. Use lowest dose possible and monitor
for respiratory depression and sedation.

pregabalin + amitriptyline

pregabalin, amitriptyline. Either increases effects of the other by pharmacodynamic synergism.

Modify Therapy/Monitor Closely. Coadministration of CNS depressants can result in serious, life-
threatening, and fatal respiratory depression. Use lowest dose possible and monitor for
respiratory depression and sedation.

enoxaparin + celecoxib

enoxaparin and celecoxib both increase anticoagulation. Modify Therapy/Monitor Closely.

heparin + aspirin

heparin and aspirin both increase anticoagulation. Modify Therapy/Monitor Closely.

heparin + celecoxib

heparin and celecoxib both increase anticoagulation. Modify Therapy/Monitor Closely.

carbamazepine + amlodipine

carbamazepine will decrease the level or effect of amlodipine by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Modify Therapy/Monitor Closely.

carvedilol + amlodipine

carvedilol and amlodipine both increase anti-hypertensive channel blocking. Modify

Therapy/Monitor Closely.

donepezil + amitriptyline

donepezil increases and amitriptyline decreases cholinergic effects/transmission. Effect of

interaction is not clear, use caution. Modify Therapy/Monitor Closely.

atenolol + clonidine

atenolol, clonidine. Mechanism: pharmacodynamic synergism. Modify Therapy/Monitor Closely.

Selective beta blocker administration during withdrawal from centrally acting alpha agonists may

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result in rebound hypertension.

losartan + atenolol

losartan and atenolol both increase serum potassium. Use Caution/Monitor.

losartan + carvedilol

losartan and carvedilol both increase serum potassium. Use Caution/Monitor.

losartan + aspirin

losartan and aspirin both increase serum potassium. Use Caution/Monitor.

losartan + celecoxib

losartan and celecoxib both increase serum potassium. Use Caution/Monitor.

atenolol + carvedilol

atenolol and carvedilol both increase serum potassium. Use Caution/Monitor.

atenolol + aspirin

atenolol and aspirin both increase serum potassium. Use Caution/Monitor.

atenolol + celecoxib

atenolol and celecoxib both increase serum potassium. Use Caution/Monitor.

carvedilol + aspirin

carvedilol and aspirin both increase serum potassium. Use Caution/Monitor.

carvedilol + celecoxib

carvedilol and celecoxib both increase serum potassium. Use Caution/Monitor.

aspirin + celecoxib

aspirin and celecoxib both increase serum potassium. Use Caution/Monitor.

amiodarone + losartan

amiodarone decreases effects of losartan by decreasing metabolism. Use Caution/Monitor. May

inhibit the conversion of losartan to its active metabolite E-3174. Importance of interaction not
established; monitor individual therapeutic response to determine losartan dosage.

aspirin + celecoxib

aspirin and celecoxib both increase anticoagulation. Use Caution/Monitor.

aripiprazole + clozapine

aripiprazole and clozapine both increase antidopaminergic effects, including extrapyramidal

symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.
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aripiprazole + metoclopramide

aripiprazole and metoclopramide both increase antidopaminergic effects, including

extrapyramidal symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.

clozapine + metoclopramide

clozapine and metoclopramide both increase antidopaminergic effects, including extrapyramidal

symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.

amitriptyline + azithromycin

amitriptyline and azithromycin both increase QTc interval. Use Caution/Monitor.

chlorpheniramine + chloral hydrate

chlorpheniramine and chloral hydrate both increase sedation. Use Caution/Monitor.

chlorpheniramine + baclofen

chlorpheniramine and baclofen both increase sedation. Use Caution/Monitor.

chlorpheniramine + buprenorphine

chlorpheniramine and buprenorphine both increase sedation. Use Caution/Monitor.

chlorpheniramine + aripiprazole

chlorpheniramine and aripiprazole both increase sedation. Use Caution/Monitor.

chlorpheniramine + clozapine

chlorpheniramine and clozapine both increase sedation. Use Caution/Monitor.

chlorpheniramine + amitriptyline

chlorpheniramine and amitriptyline both increase sedation. Use Caution/Monitor.

chloral hydrate + baclofen

chloral hydrate and baclofen both increase sedation. Use Caution/Monitor.

chloral hydrate + buprenorphine

chloral hydrate and buprenorphine both increase sedation. Use Caution/Monitor.

chloral hydrate + aripiprazole

chloral hydrate and aripiprazole both increase sedation. Use Caution/Monitor.

chloral hydrate + clozapine

chloral hydrate and clozapine both increase sedation. Use Caution/Monitor.

chloral hydrate + amitriptyline

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chloral hydrate and amitriptyline both increase sedation. Use Caution/Monitor.

baclofen + buprenorphine

baclofen and buprenorphine both increase sedation. Use Caution/Monitor.

baclofen + aripiprazole

baclofen and aripiprazole both increase sedation. Use Caution/Monitor.

baclofen + clozapine

baclofen and clozapine both increase sedation. Use Caution/Monitor.

baclofen + amitriptyline

baclofen and amitriptyline both increase sedation. Use Caution/Monitor.

buprenorphine + aripiprazole

buprenorphine and aripiprazole both increase sedation. Use Caution/Monitor.

buprenorphine + clozapine

buprenorphine and clozapine both increase sedation. Use Caution/Monitor.

buprenorphine + amitriptyline

buprenorphine and amitriptyline both increase sedation. Use Caution/Monitor.

aripiprazole + clozapine

aripiprazole and clozapine both increase sedation. Use Caution/Monitor.

aripiprazole + amitriptyline

aripiprazole and amitriptyline both increase sedation. Use Caution/Monitor.

clozapine + amitriptyline

clozapine and amitriptyline both increase sedation. Use Caution/Monitor.

carbamazepine + donepezil

carbamazepine will decrease the level or effect of donepezil by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Use Caution/Monitor.

omeprazole + ampicillin

omeprazole will decrease the level or effect of ampicillin by increasing gastric pH. Applies only to
oral form of both agents. Use Caution/Monitor.

carbamazepine + amitriptyline

carbamazepine will decrease the level or effect of amitriptyline by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Use Caution/Monitor.
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carbamazepine + buprenorphine

carbamazepine decreases levels of buprenorphine by increasing metabolism. Use

Caution/Monitor. Carbamazepine increases metabolism of buprenorphine; monitor for decreased
efficacy.

atropine IV/IM + amitriptyline

atropine IV/IM and amitriptyline both decrease cholinergic effects/transmission. Use

Caution/Monitor.

donepezil + atropine IV/IM

donepezil increases and atropine IV/IM decreases cholinergic effects/transmission. Effect of

interaction is not clear, use caution. Use Caution/Monitor. .

donepezil + clozapine

donepezil and clozapine both increase QTc interval. Use Caution/Monitor.

Minor

acetazolamide + chlorpheniramine

acetazolamide will increase the level or effect of chlorpheniramine by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

acetazolamide + omeprazole

acetazolamide will increase the level or effect of omeprazole by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

acetazolamide + losartan

acetazolamide will increase the level or effect of losartan by affecting hepatic/intestinal enzyme
CYP3A4 metabolism. Minor/Significance Unknown.

acetazolamide + aripiprazole

acetazolamide will increase the level or effect of aripiprazole by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

acetazolamide + amlodipine

acetazolamide will increase the level or effect of amlodipine by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

acetazolamide + buprenorphine

acetazolamide will increase the level or effect of buprenorphine by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

acetazolamide + dexamethasone

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acetazolamide will increase the level or effect of dexamethasone by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

acetazolamide + atorvastatin

acetazolamide will increase the level or effect of atorvastatin by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

acetazolamide + amiodarone

acetazolamide will increase the level or effect of amiodarone by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

acetazolamide + budesonide

acetazolamide will increase the level or effect of budesonide by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

aspirin + acetazolamide

aspirin will decrease the level or effect of acetazolamide by affecting hepatic/intestinal enzyme
CYP3A4 metabolism. Minor/Significance Unknown.

donepezil + atropine IV/IM

donepezil decreases effects of atropine IV/IM by pharmacodynamic antagonism.

Minor/Significance Unknown.

amitriptyline + atropine IV/IM

amitriptyline increases levels of atropine IV/IM by unknown mechanism. Minor/Significance

Unknown.

atropine IV/IM + atenolol

atropine IV/IM increases levels of atenolol by unknown mechanism. Minor/Significance

Unknown.

dexamethasone + omeprazole

dexamethasone will decrease the level or effect of omeprazole by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

acetazolamide + carbamazepine

acetazolamide will increase the level or effect of carbamazepine by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

acetaminophen IV + heparin

acetaminophen IV increases effects of heparin by unknown mechanism. Minor/Significance

Unknown.

acetaminophen IV + enoxaparin

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acetaminophen IV increases effects of enoxaparin by unknown mechanism. Minor/Significance

Unknown.

acetazolamide + acetaminophen IV

acetazolamide decreases levels of acetaminophen IV by increasing metabolism.

Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

carbamazepine + acetaminophen IV

carbamazepine decreases levels of acetaminophen IV by increasing metabolism.

Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

valproic acid + acetaminophen IV

valproic acid decreases levels of acetaminophen IV by increasing metabolism.

Minor/Significance Unknown. Enhanced metabolism incr levels of hepatotoxic metabolites.

metoclopramide + acetaminophen IV

metoclopramide increases levels of acetaminophen IV by enhancing GI absorption. Applies only

to oral form of both agents. Minor/Significance Unknown.

dexamethasone + donepezil

dexamethasone will decrease the level or effect of donepezil by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

budesonide + donepezil

budesonide will decrease the level or effect of donepezil by affecting hepatic/intestinal enzyme
CYP3A4 metabolism. Minor/Significance Unknown.

budesonide + amitriptyline

budesonide will decrease the level or effect of amitriptyline by affecting hepatic/intestinal enzyme
CYP3A4 metabolism. Minor/Significance Unknown.

celecoxib + donepezil

celecoxib will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6
metabolism. Minor/Significance Unknown.

amiodarone + donepezil

amiodarone will increase the level or effect of donepezil by affecting hepatic enzyme CYP2D6
metabolism. Minor/Significance Unknown.

celecoxib + aripiprazole

celecoxib will increase the level or effect of aripiprazole by affecting hepatic enzyme CYP2D6
metabolism. Minor/Significance Unknown.

amiodarone + aripiprazole

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amiodarone will increase the level or effect of aripiprazole by affecting hepatic enzyme CYP2D6
metabolism. Minor/Significance Unknown.

carbamazepine + celecoxib

carbamazepine will decrease the level or effect of celecoxib by affecting hepatic enzyme
CYP2C9/10 metabolism. Minor/Significance Unknown.

valproic acid + celecoxib

valproic acid will increase the level or effect of celecoxib by affecting hepatic enzyme
CYP2C9/10 metabolism. Minor/Significance Unknown.

omeprazole + carvedilol

omeprazole will increase the level or effect of carvedilol by affecting hepatic enzyme CYP2C9/10
metabolism. Minor/Significance Unknown.

amiodarone + celecoxib

amiodarone will increase the level or effect of celecoxib by affecting hepatic enzyme CYP2C9/10
metabolism. Minor/Significance Unknown.

valproic acid + clozapine

valproic acid decreases levels of clozapine by plasma protein binding competition.

Minor/Significance Unknown.

dexamethasone + amitriptyline

dexamethasone will decrease the level or effect of amitriptyline by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

dexamethasone + amlodipine

dexamethasone will decrease the level or effect of amlodipine by affecting hepatic/intestinal

enzyme CYP3A4 metabolism. Minor/Significance Unknown.

cefadroxil + aspirin

cefadroxil will increase the level or effect of aspirin by acidic (anionic) drug competition for renal
tubular clearance. Minor/Significance Unknown.

cefadroxil + celecoxib

cefadroxil will increase the level or effect of celecoxib by acidic (anionic) drug competition for
renal tubular clearance. Minor/Significance Unknown.

aspirin + celecoxib

aspirin will increase the level or effect of celecoxib by acidic (anionic) drug competition for renal
tubular clearance. Minor/Significance Unknown.

carbamazepine + amitriptyline

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carbamazepine decreases levels of amitriptyline by increasing metabolism. Minor/Significance

Unknown.

amphotericin B deoxycholate + budesonide

amphotericin B deoxycholate, budesonide. Mechanism: unspecified interaction mechanism.

Minor/Significance Unknown. Potential for hypokalemia.

amphotericin B deoxycholate + dexamethasone

amphotericin B deoxycholate, dexamethasone. Mechanism: unspecified interaction mechanism.

Minor/Significance Unknown. Potential for hypokalemia.

budesonide + calcium carbonate

budesonide decreases levels of calcium carbonate by increasing elimination. Minor/Significance

Unknown.

dexamethasone + calcium carbonate

dexamethasone decreases levels of calcium carbonate by increasing elimination.

Minor/Significance Unknown.

aspirin + folic acid

aspirin decreases levels of folic acid by inhibition of GI absorption. Applies only to oral form of
both agents. Minor/Significance Unknown.

aspirin + zoledronic acid

aspirin decreases levels of zoledronic acid by inhibition of GI absorption. Applies only to oral
form of both agents. Minor/Significance Unknown.

amikacin + calcium carbonate

amikacin decreases levels of calcium carbonate by inhibition of GI absorption. Applies only to

oral form of both agents. Minor/Significance Unknown.

dexamethasone + aspirin

dexamethasone decreases levels of aspirin by increasing renal clearance. Minor/Significance

Unknown.

ampicillin + allopurinol

ampicillin, allopurinol. Mechanism: unknown. Minor/Significance Unknown. Increased incidence

of rash.

amikacin + zoledronic acid

amikacin, zoledronic acid. Mechanism: pharmacodynamic synergism. Minor/Significance

Unknown. Additive hypocalcemia.

omeprazole + carbamazepine

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omeprazole increases levels of carbamazepine by decreasing metabolism. Minor/Significance

Unknown. Monitor plasma levels when used concomitantly.

calcium carbonate + aspirin

calcium carbonate, aspirin. Mechanism: passive renal tubular reabsorption due to increased pH.
Minor/Significance Unknown. Salicylate levels increased at moderate doses; salicylate levels
decreased at large doses (d/t increased renal excretion of unchanged salicylic acid).

ampicillin + atenolol

ampicillin decreases levels of atenolol by inhibition of GI absorption. Applies only to oral form of
both agents. Minor/Significance Unknown.

azithromycin + clozapine

azithromycin increases toxicity of clozapine by unspecified interaction mechanism.

Minor/Significance Unknown. Enhanced CNS toxicity.

azithromycin + ampicillin

azithromycin decreases effects of ampicillin by pharmacodynamic antagonism.

Minor/Significance Unknown.

aspirin + amikacin

aspirin increases levels of amikacin by decreasing renal clearance. Minor/Significance Unknown.

Interaction mainly occurs in preterm infants.

celecoxib + amikacin

celecoxib increases levels of amikacin by decreasing renal clearance. Minor/Significance

Unknown. Interaction mainly occurs in preterm infants.

carbamazepine + folic acid

carbamazepine decreases levels of folic acid by unspecified interaction mechanism.

Minor/Significance Unknown.

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