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36 Drug Interactions Checker - Medscape Drug Reference Database

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43 Interactions Found
See details below.

Patient Regimen

  escitalopram

  risperidone

  trihexyphenidyl

  aripiprazole

  folic acid

  clobazam

  fluoxetine

  lithium

  valproic acid

  amitriptyline

Serious - Use Alternative

fluoxetine + amitriptyline

fluoxetine and amitriptyline both increase serotonin levels. Avoid or Use Alternate Drug.

escitalopram + fluoxetine

escitalopram and fluoxetine both increase serotonin levels. Avoid or Use Alternate Drug.

escitalopram + amitriptyline

escitalopram and amitriptyline both increase serotonin levels. Avoid or Use Alternate Drug.

aripiprazole + fluoxetine

aripiprazole and fluoxetine both increase QTc interval. Avoid or Use Alternate Drug.

escitalopram + amitriptyline

escitalopram increases toxicity of amitriptyline by QTc interval. Avoid or Use Alternate Drug.
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fluoxetine + amitriptyline

fluoxetine will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2C19
metabolism. Avoid or Use Alternate Drug.

fluoxetine + escitalopram

fluoxetine will increase the level or effect of escitalopram by affecting hepatic enzyme CYP2C19
metabolism. Avoid or Use Alternate Drug.

fluoxetine + aripiprazole

fluoxetine will increase the level or effect of aripiprazole by affecting hepatic enzyme CYP2D6
metabolism. Avoid or Use Alternate Drug.

fluoxetine + risperidone

fluoxetine will increase the level or effect of risperidone by affecting hepatic enzyme CYP2D6
metabolism. Avoid or Use Alternate Drug.

Monitor Closely

clobazam + amitriptyline

clobazam will increase the level or effect of amitriptyline by affecting hepatic enzyme CYP2D6
metabolism. Use Caution/Monitor. Lower doses of drugs metabolized by CYP2D6 may be
required when used concomitantly.

clobazam + aripiprazole

clobazam will increase the level or effect of aripiprazole by affecting hepatic enzyme CYP2D6
metabolism. Use Caution/Monitor. Lower doses of drugs metabolized by CYP2D6 may be
required when used concomitantly.

clobazam + fluoxetine

clobazam will increase the level or effect of fluoxetine by affecting hepatic enzyme CYP2D6
metabolism. Use Caution/Monitor. Lower doses of drugs metabolized by CYP2D6 may be
required when used concomitantly.

clobazam + risperidone

clobazam will increase the level or effect of risperidone by affecting hepatic enzyme CYP2D6
metabolism. Use Caution/Monitor. Lower doses of drugs metabolized by CYP2D6 may be
required when used concomitantly.

aripiprazole + escitalopram

aripiprazole and escitalopram both increase QTc interval. Use Caution/Monitor.

aripiprazole + amitriptyline

aripiprazole and amitriptyline both increase QTc interval. Use Caution/Monitor.

lithium + aripiprazole
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lithium, aripiprazole. unspecified interaction mechanism. Use Caution/Monitor. Serotonin

modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic
malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators,
which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental
status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant
syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).

lithium + risperidone

lithium, risperidone. unspecified interaction mechanism. Use Caution/Monitor. Serotonin

modulators may enhance dopamine blockade, possibly increasing the risk for neuroleptic
malignant syndrome. Antipsychotics may enhance serotonergic effect of serotonin modulators,
which may result in serotonin syndrome. Monitor for evidence of serotonin toxicity (eg, mental
status changes, autonomic instability, and neuromuscular hyperactivity) or neuroleptic malignant
syndrome (eg, hyperthermia, muscle rigidity, autonomic dysfunction).

lithium + escitalopram

lithium and escitalopram both increase QTc interval. Use Caution/Monitor.

lithium + amitriptyline

lithium and amitriptyline both increase QTc interval. Use Caution/Monitor.

escitalopram + lithium

escitalopram and lithium both increase serotonin levels. Modify Therapy/Monitor Closely.

escitalopram + fluoxetine

escitalopram and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.

fluoxetine + lithium

fluoxetine and lithium both increase serotonin levels. Modify Therapy/Monitor Closely.

amitriptyline + lithium

amitriptyline and lithium both increase serotonin levels. Modify Therapy/Monitor Closely.

amitriptyline + fluoxetine

amitriptyline and fluoxetine both increase QTc interval. Modify Therapy/Monitor Closely.

amitriptyline + risperidone

amitriptyline and risperidone both increase QTc interval. Modify Therapy/Monitor Closely.

fluoxetine + risperidone

fluoxetine and risperidone both increase QTc interval. Use Caution/Monitor.

aripiprazole + risperidone

aripiprazole and risperidone both increase sedation. Use Caution/Monitor.

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aripiprazole + amitriptyline

aripiprazole and amitriptyline both increase sedation. Use Caution/Monitor.

risperidone + amitriptyline

risperidone and amitriptyline both increase sedation. Use Caution/Monitor.

aripiprazole + risperidone

aripiprazole and risperidone both increase antidopaminergic effects, including extrapyramidal

symptoms and neuroleptic malignant syndrome. Use Caution/Monitor.

trihexyphenidyl + amitriptyline

trihexyphenidyl and amitriptyline both decrease cholinergic effects/transmission. Use

Caution/Monitor. Potential for additive anticholinergic effects.

amitriptyline + clobazam

amitriptyline, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant

administration can increase the potential for CNS effects (e.g., increased sedation or respiratory
depression).

aripiprazole + clobazam

aripiprazole, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant

administration can increase the potential for CNS effects (e.g., increased sedation or respiratory
depression).

risperidone + clobazam

risperidone, clobazam. Other (see comment). Use Caution/Monitor. Comment: Concomitant

administration can increase the potential for CNS effects (e.g., increased sedation or respiratory
depression).

risperidone + trihexyphenidyl

risperidone increases effects of trihexyphenidyl by pharmacodynamic synergism. Use

Caution/Monitor. Potential for additive anticholinergic effects.

escitalopram + risperidone

escitalopram increases toxicity of risperidone by QTc interval. Use Caution/Monitor.

aripiprazole + risperidone

aripiprazole and risperidone both increase QTc interval. Use Caution/Monitor.

aripiprazole + lithium

aripiprazole and lithium both increase QTc interval. Use Caution/Monitor.

lithium + fluoxetine

lithium and fluoxetine both increase QTc interval. Use Caution/Monitor.

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lithium + risperidone

lithium and risperidone both increase QTc interval. Use Caution/Monitor.

Minor

lithium + amitriptyline

lithium, amitriptyline. Other (see comment). Minor/Significance Unknown. Comment: Risk of

neurotoxicity in geriatric pts. Multiple mechanisms involved.

escitalopram + lithium

escitalopram, lithium. Mechanism: unknown. Minor/Significance Unknown. Risk of neurotoxicity.

fluoxetine + lithium

fluoxetine, lithium. Mechanism: unknown. Minor/Significance Unknown. Risk of neurotoxicity.

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