Nucleic Acid

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Organized
MCQ Compilation

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Dr. Mohamed Khomsi

Fb: ‫ محمد الخمسي‬.‫د‬
May/2022
 ** 3 ‫** مفاضلة‬

1. The carbon of the pentose in ester linkage with phosphate in nucleotide structure
is : )‫نهائي‬/ 3 ‫(مفاضلة‬
a) C1
b) C2
c) C3 (e)
d) C4
e) C5

2. 2.4-Dioxy-5-methylpyrmidine is : )‫نهائي‬/ 3 ‫(مفاضلة‬

a) Adenine
b) Cytosine
c) Thymine (c)
d) Uracil
e) Guanine

3. Adenine is : )‫نهائي‬/ 3 ‫(مفاضلة‬

a) 6-amino Pyrimidine
b) 2-oxy-4-aminopyrimidine
c) 6-amino Purine (c)
d) 2-amino-6-oxypurine
e) 2,4-dioxypyrimidine

4. Purine nucleotide is : )‫نهائي‬/ 3 ‫(مفاضلة‬

a) CMP
b) DMP
c) AMP (c)
d) TMP
e) All of the above

5. in nucleotides the sugars and bases are linked by an N-glycosidic bond between :
)‫نهائي‬/ 3 ‫(مفاضلة‬
a) C1 of the sugar N1 of Purine ring
b) C1 if the sugar and N9 of Pyrimidine ring
c) C5 of the sugar and N9 of the Purine ring (e)
d) C5 of the sugar and N9 of Purine ring
e) C1 of the sugar and N9 of Purine ring

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 ** 4 ‫** مفاضلة‬

6. A Pyrimidine nucleotide is : )‫نهائي‬/ 4 ‫(مفاضلة‬

a) GMP
b) AMP
c) CMP (c)
d) IMP
e) All of the above

7. DNA rich in A-T pairs have : )‫نهائي‬/ 4 ‫(مفاضلة‬

a) 1 hydrogen bond between A and T
b) 3 hydrogen bonds between A and T
c) 4 hydrogen bonds between A and T (e)
d) High melting point
e) None of the above

8. The Purine nucleoside the phosphate is attached to the sugar by : )‫نهائي‬/ 4 ‫(مفاضلة‬
a) 3'5' Phosphodiester bonds
b) 5'3' Phosphodiester bonds
c) C1-N1 glycosidic bond (e)
d) C1-N9 glycosidic bonds
e) None of the above

** 5 ‫** مفاضلة‬

9. The base which contain 2 carbonyl groups and 1 methyl group is : )‫نهائي‬/ 5 ‫(مفاضلة‬
a) Adenine
b) Cytosine
c) Guanine (e)
d) Uracil
e) Thymine

10. What is the complimentary base pairs of 5'-TTCGCT-3' sequence of DNA strand :
)‫نهائي‬/ 5 ‫(مفاضلة‬
a) 5'-TCGCTT-3
b) 3'-AAGCGA-5'
c) 5'-ATCGCA-5' (b)
d) 3'-TTCGCT-5'
e) 5'-AAGCGA-3'

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11. One strand of the DNA molecule contains 20 As, 25 Gs, 30 Cs, 22 Ts. How many of
each found in the complete double stranded molecule : )‫نهائي‬/ 5 ‫(مفاضلة‬
a) A=40. G=50. C=60. T=44
b) A=42. G=55. C=55. T=42
c) A=44. G=60. C=50. T=40 (b)
d) A=45. G=45. C=52. T=52
e) A=50. G=47. C=50. T=47

12. in G with C base pairing the hydrogen bond is between : )‫نهائي‬/ 5 ‫(مفاضلة‬
a) one C=O- - - HNH and two NH- - - N
b) two C=O - - - HNH and one NH- - - N
c) three C=O- - - HNH (b)
d) three NH- - -N
e) one HO- - -HNH and two NH- - -N

** 6 ‫**مفاضلة‬

13. Which base of nucleic acid has one carbonyl ( ‫ نهائي‬/6 ‫)مفاضلة‬
a) C&G
b) A&G
c) T& U (a)
d) C&T
e) A&U

14. Which nucleic acid has methyl at carbon 5 ( ‫ نهائي‬/6 ‫)مفاضلة‬

a) Adenine
b) Cytosine
c) Guanine (d)
d) Thymine
e) Uracil

15. At the 5'end of DNA there is a group of ( ‫ نهائي‬/6 ‫)مفاضلة‬

a) Po4
b) CH2
c) deoxyribonucleic acid (a)
d) phosphodiester
e) hydroxyl group

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16. At the 3'end of DNA there is a group of ( ‫ نهائي‬/6 ‫)مفاضلة‬
a) Po4
b) CH2
c) deoxyribonucleic acid (e)
d) phosphodiester
e) hydroxyl group

17. The RNA type that carry amino acid is ( ‫ نهائي‬/6 ‫)مفاضلة‬
a) rRNA
b) mRNA
c) tRNA (c)
d) snRNA
e) all of the above

18. What RNA product of the DNA template sequence GATCTAC ( ‫ نهائي‬/6 ‫)مفاضلة‬
a) 5' – CTAGATC-3'
b) 5' – CUAGAUC-3'
c) 5' – GUAGAUC-3' (c)
d) 5' – CAUCUAG-3'
e) None of the above

19. All found in DNA molecule Except ( ‫ نهائي‬/6 ‫)مفاضلة‬

a) Base pairing
b) Minor groove
c) Regulatory region (e)
d) Minor grove
e) Primary transcript

** 1 ‫** مقابلة‬

20. Which of the following is a purine ( ‫ نهائي‬/1 ‫) مقابلة‬

a) Xanthine
b) Guanine
c) Adenine (e)
d) Uracil
e) All except d

21. Which of the following will act as an allosteric regulator ( ‫ نهائي‬/1 ‫) مقابلة‬
a) GTP
b) ADP
c) ATP (a)
d) AMP
e) All of the above

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22. In RNA U base is instead of ( ‫ نهائي‬/1 ‫) مقابلة‬
a) C-base
b) A base
c) Xanthine (e)
d) G base
e) T base

23. Which of the following is used as second messenger ( ‫ نهائي‬/1 ‫) مقابلة‬

a) Cyclic GMP
b) Cyclic AMP
c) Cyclic ATP (e)
d) AMP
e) a& b

24. The production of DNA from DNA is called ( ‫ نهائي‬/1 ‫) مقابلة‬

a) Transcription
b) Translation
c) Expression (e)
d) Replicription
e) Replication

** 2 ‫** مقابلة‬

25. Which of the following will act as an allosteric regulator ( ‫ نهائي‬/1 ‫) مقابلة‬
a) GTP
b) ADP
c) ATP
d) AMP
e) All of the above

26. Which of the following is used as second messenger ( ‫ نهائي‬/1 ‫) مقابلة‬

a) Cyclic GMP
b) Cyclic AMP
c) Cyclic ATP
d) AMP
e) cAMP

27. In RNA U base is instead of ( ‫ نهائي‬/1 ‫) مقابلة‬

a) C-base
b) A base
c) Xanthine
d) G base
e) T base

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28. The production of DNA from DNA is called ( ‫ نهائي‬/1 ‫) مقابلة‬
a) Transcription
b) Translation
c) Expression
d) Replicription
e) Replication

29. The production of DNA from DNA is called ( ‫ نهائي‬/1 ‫) مقابلة‬

a) Transcription
b) Translation
c) Expression
d) Replicription
e) Replication

** ‫** السنوات الماضية‬

30. Nucleotides serve all of the following roles except :

a) monomeric units of nucleic acids
b) physiological mediators
c) Sources of chemical energy (d)
d) structural components of membranes
e) structural components of coenzymes

31. The A helix of DNA differs from the B helix in all of the following except :
a) appearance of the major and minor grooves .
b) pitch of the base pairs relative to the helix axis
c) thickness of the helix (e)
d) tilt of the base
e) polarity of the strands

32. nucleotides serve the following functions

a) structural units of nucleic acids
b) source of chemical energy
c) physiological second messengers (e)
d) components of coenzymes
e) all of the above are true

33. regarding DNA structure

a) chromosomal DNA consists mainly of B form
b) DNA coding regions are often interrupted by non-coding regions (d)
c) Removal of histones of DNA leads to defective structure
d) All of the above are true
e) Only a & b are true

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34. DNA and RNA all are true except
a) Both DNA & RNA contain Purine bases Adenine & guanine
b) Unusual modified bases are found usually in DNA
c) DNA contains pyrimidine base thiamine & RNA contains uracil (b)
d) Thymine & uracil by presence of methyl on thymine but not on uracil
e) Deoxyribonuleotides are found on DNA & ribonucloeides on RNA

35. Regarding DNA helix

a) the exterior back bone is composed of sugar & phosphate linked by 3'5'
phosphodiester bond
b) the interior is composed of purine & pyrimidine bases linked by hydrogen bonds
c) the two strands of the double helix are anti-parallel (e)
d) phosphate is found on the 5 end & Oh is found on the 3 end
e) all of the above is true

36. nucleotides at physiological pH are

a) negatively charged
b) positively charged (a)
c) can be both
d) none of the above

37. in nucleosides and nucleotides the sugar and bases are linked by
a) nitrogenous
b) covalent (d)
c) phosphodiester
d) β-n-glycosidic

38. the main form of chromosomal DNA that Is usually found under physiological
conditions
a) A form
b) B form
c) C form (b)
d) E form
e) Z form

39. the type of RNA that has a site of amino acid attachment at the 3 end
a) iRNA
b) rRNA
c) tRNA (c)
d) mRNA
e) snRNA

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40. The annealing of double stranded DNA after denaturation involved the bond
a) Hydrogen bond
b) Covalent bond
c) Phosphodiester bond (a)
d) b-N-glycosidic bond
e) nitrogenous

41. Denaturing of DNA double stands by heat breaks the following bond
a) Hydrogen
b) Covalent
c) Phosphodiester (a)
d) b-N-glycosidic bond
e) nitrogenous

42. Uracil is
a) 2,4-dioxypyrimidine
b) 4-amino-oxypyrimidine (a)
c) 2,4-dioxy-5-methyl pyrimidine
d) 4-oxy-2-aminopyrimidine

43. Nucleotides is converted into nucleoside by removing

a) Phosphate
b) Pyrimidine base
c) Deoxy-pentose (a)
d) Pruine base
e) Pentose

44. All the following about human common form of DNA are correct except:
a) Antiparallel
b) 10 BP per turn
c) Helical (d)
d) B form
e) Left handed

45. Select the false statement

a) cGMP is a nucleus acid derivative formed by gunalyl cyclase
b) Nucleosides combine with phosphoric acid to form a nucleotides
c) ATP is a nucleotide that participates in the formation of nucleus acid and high (d)
energy compounds

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46. The width (helical diameter) of double helix of B form
a) 1
b) 2
c) 3 (b)
d) 3.4
e) 2.3

47. Translation results in a product known as

a) protein
b) tRNA
c) mRNA (a)
d) rRNA

48. Reverse transcriptase is capable of synthesizing

a) RNA from DNA
b) DNA from RNA (a)
c) RNA from RNA
d) DNA from DNA

49. In DNA the complementary base of adenine is

a) Guanine
b) cytosine
c) Uracil (d)
d) thymine

50. In DNA, three hydrogen bounds are formed between

a) Adenine and guanine
b) Adenine and thymine
c) Guanine and cytosine (c)
d) thymine and cytosine

51. Left-handed double helix is present in

a) Z-DNA
b) A-DNA (a)
c) B-DNA
d) none of the above

52. Extra-nuclear DNA is present in

a) ribosomes
b) endoplasmic reticulm (d)
c) lysosomes
d) mitochondria

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53. 10 base pairs are present in one turn of the helix of
a) A-DNA
b) B-DNA
c) C-DNA (b)
d) Z-DNA

54. Transfer RNA transfers

a) information from DNA to ribosomes
b) information from mRNA to cytosol (c)
c) amino acids from cytosol to ribosomes
d) proteins from ribosomes to cytosol

55. In RNA the complementary base of adenine is

a) cytosine
b) guanine (d)
c) thymine
d) Uracil

56. Which of the following statements about nucleic acid is most correct
a) both pentose nucleic acid and deoxypentose nucleic acid contain the same
Pyrimidines
b) both pentose nucleic acid and deoxypentose nucleic acid and deoxypentose nucleic
acid contain the same Purines (b)
c) RNA contains cytosine and thymine
d) DNA and RNA are hydrolyzed by weak alkali

57. Transcription is the formation of:

a) DNA from a parent DNA
b) mRNA from a parent mRNA
c) mRNA from DNA (c)
d) protein through mRNA

58. Translation is the formation of:

a) DNA from DNA
b) mRNA from DNA
c) protein through mRNA (c)
d) mRNA from pre mRNA

59. In addition to the DNA of nucleus there DNA is:

a) mitochondria
b) endoplasmic reticulum (a)
c) golgi apparatus
d) plasma membrane

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60. Genetic information in human beings is stored in
a) RNA
b) DNA (b)
c) mRNA
d) both a and b

66. A Purine nucleotide is:

a) AMP
b) UMP (a)
c) CMP
d) TMP

67. A Pyrimidine nucleotide is :

a) GMP
b) AMP (c)
c) CMP
d) IMP

68. Adenine is:

a) 6-amino Purine
b) 2-amino-6-oxypurine (a)
c) 2,4-dioxypyrimidine
d) 2-oxy-4-aminopyrimidine

69. 2,4 dioxypyrimidine is:

a) thymine
b) cytosine (c)
c) Uracil
d) guanine

70. The chemical name of guanine is:

a) 2,4-dioxy-5-methylpyrimidine
b) 2,4 dioxypyrimidine (d)
c) 2-oxy-4-aminopyrimidine
d) 2-amino-6-oxypurine

71. Uracil and ribose form:

a) Uridine
b) Cytidine (a)
c) Adenosine
d) Guanosine

72. The most abundant free nucleotide in mammalian cells is:

a) ATP
b) NAD
c) FAD (a)
d) GTP

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73. The pyrimidine nucleotide acting as the high energy intermediate is:
a) ATP
b) UTP
c) UDP (b)
d) CMP

74. In RNA molecule

a) guanine content equal cytosine
b) adenine content equals uracil (d)
c) adenine content equals guanine
d) guanine content doesn’t necessarily equal its cytosine

75. UTP IS converted to CTP by

a) Methylation
b) Ismerisation
c) Amination (c)
d) Reduction

76. In DNA molecule :

a) guanine does not equal cytosine content
b) Adenine content doesn't equal thymine content (d)
c) Adenine content equals uracil content
d) Guanine content equal cytosine

77. DNA rich in G-C pairs

a) 2 hydrogen bonds
b) 3 hydrogen bonds (b)
c) 4 hydrogen bonds

78. The width of the double helix in B-form DNA in nm is

a) 1
b) 2 (b)
c) 3

79. The number of base pair in a single turn of B-form DNA about the axis of the
molecule is
a) 4
b) 8
c) 10 (c)
d) 12

80. In a DNA molecule the thymine concentration is 30%, the guanosine concentration
will be
a) 10%
b) 20% (b)
c) 30%
d) 40%

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