# 19 script

Nag po-produce ng elevated gastrin levels ang proton pump inhibitors, dahil sa long term use of proton
inhibitor therapy, may consequences to na mag lead sa enterochromaffin-like cell hyperplasia.
enterochromaffin ay type of neuroendocrine or neurosecretory cells and ang hyperplasia ay pag laki ng
organ or tissue caused by an increase in the amount of organic tissue that results from cell proliferation
or nag increase yung number of cells. During daytime postprandial period of long term use of proton
inhibitor therapy ay may chance na magkaroon ng micronutrient deficiency tulad ng decreasing levels of
iron, calcium and vitamin B12 at Malaki ang posibilidad na magkaroon ng pathological condition kase sa
lack of nutrients. May ibang study din na ipinapakita na ang pag gamit ng long term use of proton
inhibitor therapy ay nag cacause or may risk ng enteric infections tulad ng clostridioides difficile, isang
bacterium that causes infection of the large intestine (colon).