2/23/2021
The micro RNAs are double stranded RNA molecules
Altered skeletal development is demonstrated when there
The skeletal impact
is an alterations of normal microRNAs function.
microRNAs have shown important regulation of
chondrogenesis. So, they may have important
implications in tissue repair and building.
Numerous microRNAs could induce apoptosis and inhibit
it as well. And at the same time by they inhibit apoptosis,
they can induce autophagy in stress situations.
Vesicles released from senescent chondrocytes to the
Chondrocyte deterioration
extracellular fluid containing different concentrations of
microRNAs can induce senescence to normal
chondrocytes.
MicroRNAs are stable and able to find in the systemic
circulation. And several studies have shown some
microRNAs as possible biomarkers of osteoarthritis. But
among different population studies, the amount and type
of microRNAs likely to serve as biomarkers changes and
just a few of them remain as a real possibility.
References
1. Swingler TE, Niu L, Smith P, Paddy
P, Le L, Barter MJ, et al. The function
of microRNAs in cartilage and
osteoarthritis. Clin Exp Rheumatol.
2019;37(5):40–7.
https://whimsical.com/the-function-of-micrornas-in-cargilage-an-osteoarthritis-1-Xg1W39tFkXyjGLxj8w7VmY
The function of microRNAs in cargilage an osteoarthritis (1)
containing 22 nucleotides approximately. That negatively
regulate gene expression in a post - transcriptional level.
They arise from introns, intergenic portions and in a less
rate from exons. They are transcribed by RNA Pol.II and
The biology
exported to the cytoplasm, where the doble strained chain
becomes single strained and stablish a complex with
mRISC. This complex inhibits the transcription of mRNAs
by biding in their 3'UTR region.
Cartilage from osteoarthritis patients and cartilage from
healthy patients tend to have different expression of
DIfferential expression microRNAs. 46 microRNAs are expressed different and
are involved in pathological processes that contribute to
the development of osteoarthritis.
Chondrogenesis
MicroRNAs participate in most of the osteoarthritis
signaling pathways involved in the pathogenesis of this
Signaling sickness. For example, excessive expression of a certain
types of microRNAs have shown to suppress
chondrogenesis and MEC production.
The function of microRNAs in
cargilage an osteoarthritis (1)
Although the participation of microRNAs in the
pathogenesis of osteoarthritis is not fully understood, the
deletion of specific microRNAs that have shown a crucial
role in skeletal development, produce negative
Deletion consequences in animal models that tend to develop long
term cartilage damage. Additional to skeletal
development, certain MicroRNAs are important for
cartilage homeostasis, and their impairment has negative
outcomes too.
Biomarkers
Demonstrated the participation of microRNAs in multiple
cartilage functions and impairments. A therapeutic use for
exogenous inhibitor or more microRNAs has been tested
in animal models and in vitro. But the majority involves
intracellular injections, and joint injections in which is not
The terapeutic
clear the uptake of the specific molecules by the
chondrocytes. Viral induces uptake works in animal
models, and techniques with exosomes seems to be the
work line for cellular uptake and future human treatment.
correo: jduartez@unal.edu.co
Hecho por: Juan Felipe Duarte
Zambrano
CC. 1010077553
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