Non-severe: Low cell counts, may be asymptomatic , watchful waiting,

condition may not change

Can be moderate or severe

Severe AA: Neutrophil Aplastic Anemia is a rare
counts < 500, condition where the bone
Reticulocyte count < Between 600-900 people are
1-Definition marrow cannot produce an
20.000, platelet count diagnosed annually in the U.S.
< 20,000
Types adequate number of red blood
cells.
Can happen at any age
Very Severe AA:
Platelet count < 200;
all other blood counts
comparable to severe A bone marrow transplant, aka stem cell transplant,
AA often cures bone marrow failure.

Antibiotic therapy for recurring infections

Complete blood count (CBC) 2-Treatment
reveals pancytopenia: low
WBC, RBC, and platelet counts Blood Transfusions.

Liquid and solid bone marrow Immunosuppresive therapy

samples are tested to confirm a Bone Marrow Test
diagnosis

Infectious Disease
This test determines if
bone marrow is producingnew
Aplastic anemia
RBCs
Diagnostic Tests Treatments for other
Reticulocyte count shows autoimmune disorders
numbers of young like Rheumatoid Arthritis
red blood cells
Low levels Autoimmune Mechanisms
are typically and Lupus.
seen in AA
3-Causes
Contributes to most AA cases
Erythropoietin, iron,
vitamin B12, and folate
levels rule out other Drugs
causes of anemia

Chemotherapy and Radiation

Recurring infections due to neutropenia

Toxins

Frequent bleeding and mennorhagia due to

thrombocytopenia
Cells are replaced with fat

Tired, difficulty concentrating

Clinical Presentation
Pathophysiology
Bone marrow HPCs are the source
Loss of hematopoietic stem cells of mature cells in peripheral blood
Pale Skin and tissues

Shortness of Breath