GHS Classification Result

ID： 25A0056
CAS： 91-59-8 Year Classified: FY2013
Chemica2-Naphthylamine; beta-Naphthylamine Reference Manual: GHS Classification Guidance by the Japanese Government (July, 2013)

PHYSICAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification

1 Explosives Not applicable - - - - There are no chemical groups associated with explosive properties present in the molecule.

Flammable gases (including chemically

2
unstable gases) Not applicable - - - - Solid (GHS definition)

3 Aerosols Not applicable - - - - Not aerosol products.

4 Oxidizing gases Not applicable - - - - Solid (GHS definition)

5 Gases under pressure Not applicable - - - - Solid (GHS definition)

6 Flammable liquids Not applicable - - - - Solid (GHS definition)

7 Flammable solids Classification not possible - - - - It is combustible, but the classification is not possible due to no data.

Self-reactive substances and There are no chemical groups present in the molecule associated with explosive or self-
8
mixtures Not applicable - - - -
reactive properties.

9 Pyrophoric liquids Not applicable - - - - Solid (GHS definition)

10 Pyrophoric solids Classification not possible - - - - No data available.

11 Self-heating substances and mixtures Classification not possible - - - - Test methods applicable to solid (melting point <= 140 deg C) substances are not available.

Substances and mixtures which, in

The chemical structure of the substance does not contain metals or metalloids (B, Si, P, Ge,
12 contact with water, emit flammable Not applicable - - - -
As, Se, Sn, Sb, Te, Bi, Po, At).
gases

13 Oxidizing liquids Not applicable - - - - Solid (GHS definition)

14 Oxidizing solids Not applicable - - - - Organic compounds containing no oxygen, fluorine or chlorine.

15 Organic peroxides Not applicable - - - - Organic compounds containing no bivalent -O-O- structure in the molecule.

16 Corrosive to metals Classification not possible - - - - Test methods applicable to solid substances are not available.

HEALTH HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification

1 Acute toxicity (Oral) Classification not possible - - - - Classification not possible due to lack of data.

1 Acute toxicity (Dermal) Classification not possible - - - - Classification not possible due to lack of data.

1 Acute toxicity (Inhalation: Gases) Not applicable - - - - Solid (GHS definition)

1 Acute toxicity (Inhalation: Vapours) Not applicable - - - - Solid (GHS definition)

 Acute toxicity (Inhalation: Dusts and
1 mists) Classification not possible - - - - Classification not possible due to lack of data.

2 Skin corrosion/irritation
Classification not possible
- -
Classification not possible due to lack of data. Besides, it is described in HSDB (Access on
October 2013) that this substance is mildly irritating to the skin and has produced contact
- -
dermatitis. However, because it is unknown whether it corresponds to Category 3 in UN GHS
("Not classified" in JIS), it was classified as "Classification not possible".

3 Serious eye damage/eye irritation Classification not possible - - - - Classification not possible due to lack of data.

4 Respiratory sensitization Classification not possible - - - - Respiratory sensitization: Classification not possible due to lack of data.

4 Skin sensitization Classification not possible - - - - Classification not possible due to lack of data.

5 Germ cell mutagenicity
P308+P313 : IF exposed or
concerned: Get medical
advice/attention.
P201 : Obtain special
instructions before use. As for in vivo, among tests with mouse bone marrow cells, it was positive in a micronucleus
P202 : Do not handle until all test, equivocal in a chromosomal aberration test, and positive in a sister chromatid exchange
H341 : Suspected of causing safety precautions have been test (NTP DB (Access on September 2013)). As for in vitro, it was positive in a bacterial
Category 2 Health Hazard Warning
genetic defects read and understood. reverse mutation test, a chromosomal aberration test and a mouse lymphoma test with
P280 : Wear protective cultured mammalian cells (NTP DB (Access on September 2013)). From the above, it was
gloves/protective clothing/eye classified in Category 2.
protection/face protection.
P405 : Store locked up.
P501 : Dispose of
contents/container to ...

P308+P313 : IF exposed or
concerned: Get medical
advice/attention.
P201 : Obtain special
instructions before use.
P202 : Do not handle until all
safety precautions have been
6 Carcinogenicity Category 1A Health Hazard Danger H350 : May cause cancer
read and understood.
P280 : Wear protective
gloves/protective clothing/eye
protection/face protection.
P405 : Store locked up.
P501 : Dispose of
contents/container to ...
This substance was classified in Category 1A because it is classified in Group 1 by IARC (IARC
100F (2012)), A1 by ACGIH (ACGIH (1987)), K by NTP (NTP RoC (1980)), and Carc. 1A in EU
CLP (ESIS (Access on Sept 2013)). Besides, urinary tract tumors due to work involving
exposure to beta-naphthylamine, a carcinogen, are included in Disease designated by the
Minister of Health, Labour and Welfare under the Industrial Safety and Health Act in Japan, and
its manufacture is prohibited. It is concluded in IARC 100F (2012) that there was sufficient
evidence in humans for the carcinogenicity of this substance in the urinary bladder. It is
reported that many cases of bladder cancer in workers exposed to this substance were found,
and the cumulative incidence was 25%. Furthermore, as for the relationship between exposure
of workers engaged in manufacturing and use of this substance and the risk of urinary bladder
cancer, 11 cohort studies in the United States, the United Kingdom, Japan, Poland, Russia, and
Italy are available, all of which showed that the risk of human bladder cancer was significantly
increased. For example, 26 bladder-cancer deaths were observed in British dyestuff-industry
workers exposed to this substance, with an expected value of 0.3 (Standardized Mortality
Ratio (SMR) 86.7, 95% CI: 56.6-127.0), and 58 cases of bladder cancer were found in the British
rubber industry workers from 1946 to 1949 when antioxidants containing this substance were
used (Standardized Incident Ratio (SIR) 1.71; 95% CI: 1.3-2.21).

7 Reproductive toxicity Classification not possible - - - - Classification not possible due to lack of data.

Specific target organ toxicity - Single

8
exposure Classification not possible - - - - Classification not possible due to lack of data.

Specific target organ toxicity -

9
Repeated exposure Classification not possible - - - - Classification not possible due to lack of data.

10 Aspiration hazard Classification not possible - - - - Classification not possible due to lack of data.

ENVIRONMENTAL HAZARDS
Hazard class Classification Symbol Signal word Hazard statement Precautionary statement Rationale for the classification
P273 : Avoid release to the
environment. From 72-hour ErC50 = 0.50 mg/L for algae (Pseudokirchneriella subcapitata) (Results of
11 Hazardous to the aquatic Category 1 Environment Warning H400 : Very toxic to aquatic life P391 : Collect spillage. Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan
environment (Acute)
P501 : Dispose of (Ministry of the Environment, 2002)), it was classified in Category 1.
contents/container to ...

11 Hazardous to the aquatic
environment (Long-term)
12 Hazardous to the ozone layer
Category 1
Classification not possible
If chronic toxicity data are used, then it is classified in Category 1 due to being not rapidly
degradable (BIOWIN), and 21-day NOEC = 0.014 mg/L for crustacea (Daphnia magna) (Results
of Aquatic Toxicity Tests of Chemicals conducted by Ministry of the Environment in Japan
P273 : Avoid release to the (Ministry of the Environment, 2002)).
environment.
Environment Warning H410 : Very toxic to aquatic life
P391 : Collect spillage.
If acute toxicity data are used for a trophic level for which chronic toxicity data are not
with long lasting effects obtained, then it is classified in Category 2 due to being not rapidly degradable (BIOWIN), and
P501 : Dispose of 96-hour LC50 = 3.9 mg/L for fish (Oryzias latipes) (Results of Aquatic Toxicity Tests of
contents/container to ... Chemicals conducted by Ministry of the Environment in Japan (Ministry of the Environment,
2002)).
By drawing a comparison between the above results, it was classified in Category 1.
- - - - This substance is not listed in the Annexes to the Montreal Protocol.