Professional Documents
Culture Documents
Anaphylaxis
Adrenaline (epinephrine) 500 micrograms in 0.5ml (1 in 1000) IM injection in pre-filled auto-
injector pen (Emerade ®)
Status Epilepticus
Midazolam Buccal 10mg in 2ml Sugar Free oromucosal solution in prefilled syringe
Diazepam 10mg rectal tubes
Hypoglycaemia
40% Dextrose in aqueous gel for oral administration (Dextrogel® or GlucoGel®)
Glucagon 1mg powder and solvent for solution for injection 1mg in 1ml (GlucaGen Hypokit ®)
Glucose 10% w/v solution for infusion
Camden & Islington NHS Foundation Trust: Emergency medicines: PHA59: April 2017 1
Emergency Medicines
Overdose
OPIOIDS - Naloxone Hydrochloride 400 micrograms/ml solution for injection
BENZODIAZEPINE - Flumazenil 0.1 mg/ml solution for injection
Meningococcal disease
Benzyl Penicillin Sodium 600mg powder for injection
Cefotaxime 1 g powder for injection
Dilution Liquids
Water for Injections BP
Sodium Chloride Injection BP 0.9% w/v
Sodium Chloride Intravenous Infusion BP 0.9% w/v
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Anaphylaxis
medicines in the emergency bag
Medicine name Adrenaline (epinephrine) 500 microgram in 0.5ml
Solution for IM injection in pre-filled pen
EMERADE®
Dosage Adult
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Anaphylaxis
medicines in the emergency bag
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Acute Coronary Syndromes
medicines in the emergency bag
Medicine name Adrenaline (epinephrine)
1 mg in 10 ml (1:10,000 ten thousand)
Solution for injection in pre-filled syringe
Available in bag 3 x Prefilled syringes
Administration • Intravenous adrenaline should only be administered by those experienced
in the use and titration of vasopressors in their normal clinical practice
• Endotracheal use should only be considered as a last resort if no other
route of administration is accessible
• Only clear colourless solution free from particles or precipitates should be
used
• Do not use if the pouch or the blister has been opened or if the tamper
evident seal on the syringe (plastic film at the basis of the end cap) is
broken
Dosage Adult
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Acute Coronary Syndromes
medicines in the emergency bag
Adrenaline 1 mg/10 ml (1:10,000 ten thousand), solution for injection in pre-filled syringe
Discard the syringe after use, do not re-use
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Acute Coronary Syndromes
medicines in the emergency bag
Dosage Adult
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Acute Coronary Syndromes
medicines in the emergency bag
Administration • One or two sprays should be administered into the mouth, preferably
onto or under the tongue
• Do not inhale spray
• The medication should not be expectorated or the mouth rinsed for 5 to 10
minutes following administration
• A spray may be repeated every 3-5 minutes as needed
• No more than three metered sprays are recommended within a 15-
minute period. If chest pain persists, prompt medical attention is
recommended
Dosage Adult
Treatment or prophylaxis of angina, spray 1–2 doses under tongue and then
close mouth. Dose may be repeated as required.
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Acute Coronary Syndromes
medicines in the emergency bag
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Status Epilepticus
medicines in the emergency bag
Dosage Adult
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Status Epilepticus
medicines in the emergency bag
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Status Epilepticus
medicines in the emergency bag
Diazepam 10mg
Rectal Tubes
(1 of 2)
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Status Epilepticus
medicines in the emergency bag
Diazepam 10mg
Rectal Tubes
(2 of 2)
Note: Doses of insulin and oral hypoglycaemic medicine will need to be reviewed following an
episode of hypoglycaemia. Please contact Diabetes Specialist Nurse or doctor for advice.
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Hypoglycaemia - mild
medicines in the emergency bag
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Hypoglycaemia - moderate
medicines in the emergency bag
GlucaGen Hypokit® 1mg powder and solvent for solution for injection
1. Push the orange plastic cap 2. Without withdrawing the 3. Ensure that the plunger is 4. The solution is used for
off the vial. Pull the needle cover syringe and needle gently shake completely depressed. injection. Ensure there is no air
off the syringe and insert the the vial until GlucaGen is Withdraw all of the solution remaining in the syringe before
needle through the rubber disc completely dissolved and the back into the syringe. Be careful giving the injection. When the
of the vial. Inject all the liquid solution is clear that the plunger is not pulled patient responds administer oral
from the syringe into the vial. out of the syringe carbohydrate to prevent a
further “hypo”
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Hypoglycaemia - severe
medicines in the emergency bag
Administration • Glucose 10% w/v solution for intravenous infusion is a hypertonic solution
• The osmolarity of a final admixed infusion solution must be taken into
account when peripheral administration is considered
• A gradual increase of flow rate should be considered when starting
administration of glucose-containing products
• Caution irritant & may cause extravasation
Dosage Adult
Give 150-160mls 10% w/v Glucose intravenously (if patient has IV access)
over 10-15 minutes
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Overdose - OPIOID
medicines in the emergency bag
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Overdose – BENZODIAZEPINE
medicines in the emergency bag
Medicine name Flumazenil 0.1 mg / 1ml solution for injection
5ml ampoules containing 500 micrograms
Available in bag 5 x 5ml ampoules (500 micrograms)
Administration • Flumazenil must be administered by medical staff only
• Intravenous (IV) administration
• Avoid rapid injection in high risk patients
• Short-acting (repeat doses may be necessary - benzodiazepine effects
may persist for at least 24 hours)
• Caution: prolonged benzodiazepine therapy for epilepsy (risk of
convulsions)
• Caution: head injury (rapid reversal of benzodiazepine sedation may
cause convulsions)
Dosage Adult (Unlicensed indication)
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Reversible airways obstruction
medicines in the emergency bag
Administration
• To be administered by a suitable nebuliser, via a face mask or T piece or
via an endotracheal tube
• To be breathed in through the mouth
Dosage Adult
The usual starting dose is 2.5mg as a single dose. This may be increased to
5mg.
• Salbutamol Nebuliser Solution is designed to be used undiluted. However,
if a prolonged delivery time is indicated (more than 10 minutes) then
dilution with Sodium Chloride Solution (0.9% w/v) for nebulisation may be
required
• For oxygen driven delivery patients should be given 5mg for 5 minutes with
6 litres of oxygen
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Reversible Airways Obstruction
medicines in the emergency bag
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Meningococcal Disease
Medicines in the Emergency Drug Cupboard
(not in emergency bag)
• Single dose should be given, if time, whilst waiting for urgent transfer to hospital
• If possible obtain a blood sample (white blood cell count and lactate) for culture analysis
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Dilution Liquids
in the emergency bag
Dosage Refer to the instructions for each individual medicinal product for details
of volume of diluent and route of administration
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Dilution Liquids
in the emergency bag
Dosage Refer to the instructions for each individual medicinal product for
details of volume of diluent and route of administration
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Dilution Liquids
in the emergency bag
Medicine name Sodium Chloride Intravenous Infusion BP 0.9% w/v
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References
ANAPHYLAXIS:
1. C&I Foundation Trust Anaphylaxis Guidelines May 2014
2. Resuscitation Council (UK) Emergency treatment of anaphylactic reactions: Guidelines for healthcare providers. www.resus.org.uk
January 2008 (annotated with links to NICE guidance in July 2012)
3. NICE clinical guidance (CG 134): Anaphylaxis: assessment to confirm an anaphylactic episode and the decision to refer after emergency
treatment for a suspected anaphylactic episode. Available at: https://www.nice.org.uk/guidance/CG134 (Accessed: 10/05/2016)
4. EMC (2016) Emerade, 500 micrograms, solution for injection in pre-filled pen, Available at:
https://www.medicines.org.uk/emc/medicine/28631 (Accessed: December 2016).
5. BNF - Medicines Complete (2016) ADRENALINE/EPINEPHRINE, Available at
http://dx.doi.org/10.18578/BNF.844811582 (Accessed: December 2016)
CARDIAC ARREST
1. BNF On line, Medical emergencies in the community, Available at: https://www.medicinescomplete.com/mc/bnf/current/PHP78126-
medical-emergencies-in-the-community.htm?q=soluble%20aspirin&t=search&ss=text&tot=8&p=6#_hit (Accessed: 02/11/2016).
2. Handbook of Drug Administration via Enteral Feeding Tubes , Dispersible aspirin, Available at
:https://www.medicinescomplete.com/mc/tubes/current/c38.htm?q=aspirin&t=search&ss=text&tot=2&p=1#_hit (Accessed: 2/11/2016)
3. Thomas & Guy Foundation Trust - Using your GTN spray to treat your chest pain, Leaflet number: 2484/VER3 Date published:
February 2016 © 2016 Guy’s and St Thomas’ NHS Foundation Trust. Available at:
http://www.guysandstthomas.nhs.uk/resources/patient-information/cardiovascular/using-your-GTN-spray-to-treat-your-chest-pain-
discomfort.pdf. (Accessed: 2/11/2016).
4. Drugs Data Base – NITROLINGUAL - nitro-glycerine spray, metered Physicians Total Care, Inc. Available at www.drugsDB.eu.
(Accessed on 2/11/206).
Camden & Islington NHS Foundation Trust: Emergency medicines: PHA59: April 2017 28
References
CARDIAC ARREST
1. BNF (Medicines Complete) (2016) Aspirin, Available at: http://dx.doi.org/10.18578/BNF.456850132 (Accessed: May 2016).
2. EMC (2015) Boots Aspirin 300mg Dispersible Tablets, Available at: http://www.medicines.org.uk/emc/medicine/30290 (Accessed: May
2016).
3. EMC (2016) Adrenaline 1 mg/10 ml (1:10,000), solution for injection in pre-filled syringe, Available at:
http://www.medicines.org.uk/emc/medicine/31592 (Accessed: May 2016).
STATUS EPILEPTICUS
1. Holsti M, Dudley N, Schunk J, Adelgais K, Greenberg R, Olsen C, Healy A, Firth S, & Filloux F (2010). Intranasal midazolam vs rectal
diazepam for the home treatment of acute seizures in paediatric patients with epilepsy. Archives of paediatrics & adolescent medicine,
164 (8), 747-53 PMID: 20679166
2. Wong L, McQueen KD. Midazolam routes of administration. DICP Ann Pharmacother 1991; 25: 476–7. PubMed
3. EMC (2016) BUCCOLAM 2.5mg, 5mg, 7.5mg and 10 mg oromucosal solution,Available at:
https://www.medicines.org.uk/emc/medicine/25538 (Accessed: October 2016).
4. BNF - Medicines Complete (2016) DIAZEPAM, Available at http://dx.doi.org/10.18578/BNF.273684709 (Accessed: August 2016)
5. EMC (2015) Diazemuls, Available at: http://www.medicines.org.uk/emc/medicine/520 (Accessed: August 2016).
EMC (2015) Diazepam RecTubes 10mg, Available at http://www.medicines.org.uk/emc/medicine/12170 (Accessed: August 2016).
6. Orange County EMS (2016) Rectal Administration of Diazepam Gel , Available at
http://www.orangecountyfl.net/emsref/EMSrefMainMenu/ProcedureManual/MedicationAdministration.aspx (Accessed: September
2016).
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References
HYPOGLICAEMIA
1. Baldwin E.J, Feher, M.D Sweets, fluids and food in the treatment of mild hypoglycaemia. Practical diabetes international 2006 , Vol 23,
N 5, p 218-220
2. Diabetes UK (2016) HYPOS AND HYPERS, Available at: http://www.diabetes.org.uk/ (Accessed: November 2016).
3. BNF (Medicines Complete) (2016) GLUCAGON, Available at: http://dx.doi.org/10.18578/BNF.127583135 (Accessed: October 2016).
4. Dr M.Barnard, E. Baker - Whittington Trust Hospital (2013) Hypoglycaemia Management for Adult Inpatients with Diabetes, Available
at: http://www.whittington.nhs.uk/diabete s a (Accessed: September 2016).
5. EMC - SPC (2015) GlucaGen Hypokit 1 mg, Available at: http://www.medicines.org.uk/emc/medicine/4258 (Accessed: September
2016).
6. Medicines Complete (2016) Treatment of hypoglycaemia, Available at: http://dx.doi.org/10.18578/BNF.706830076 (Accessed:
November 2016).
7. NeoCeuticals Dextrogel - Fast Acting Dextrose Gel, Available at: http://www.dextro-gel.co.uk/ (Accessed: September 2016).
8. Novo Nordisk Pharmaceuticals Ltd. (2015) GlucaGen™ KIT 1 mg, Available at: http://doctor-deena.blogspot.co.uk/2015/12/how-to-use-
glucagon-for-treatment-of.html (Accessed: May 2016).
MENINGOCOCCAL DISEASE
1. EMC (2016),Cefotaxime Powder for solution for injection or infusion Available at:
https://www.medicines.org.uk/emc/medicine/7339 (Accessed: December 2016).
2. BNF (Medicines Complete) (2016) CEFOTAXIME, Available at: http://dx.doi.org/10.18578/BNF.400806124 (Accessed: December 2016).
3. EMC (2016), Benzyl penicillin sodium 600mg Powder for Injection Available at: https://www.medicines.org.uk/emc/medicine/2962
(Accessed: December 2016).
4. BNF (Medicines Complete) (2016) BENZYLPENICILLIN SODIUM(Penicillin G) , Available at: http://dx.doi.org/10.18578/BNF.975478351
(Accessed: December 2016).
5. C&I Foundation Trust Antimicrobial Guidelines available on Trust Intranet.
DILUTION LIQUIDS
1. EMC (2015) Sterile water for injection, Available at: http://www.medicines.org.uk/emc/medicine/28705 (Accessed: August 2016).
2. EMC (2016) Sodium Chloride Intravenous Infusion BP 0.9% w/v , Available at:
https://www.medicines.org.uk/emc/medicine/30221 (Accessed: August 2016).
3. BNF (Medicines Complete) (2016) , SODIUM CHLORIDE Available at: http://dx.doi.org/10.18578/BNF.345805218 (Accessed:
December 2016).
4. National Institute for Health and Care Excellence (July 2016) Sepsis: recognition, assessment and early management (NG51) available
at: nice.org.uk/guidance/ng51
LEGAL REQUIREMENTS
1. Human Medicines Regulations 2012 – SCHEDULE 19 Medicinal products for parenteral administration in an emergency . Available at
http://www.legislation.gov.uk/uksi/2012/1916/schedule/19/made (Accessed: December 2016)
2. Resuscitation Council UK (2016) , Mental health - Inpatient care - equipment and drug lists, Available at https://www.resus.org.uk/
(Accessed December 2016)
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