BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE, Pilani, Pilani Campus FIRST SEMESTER 2021-22 COURSE HANDOUT Date: 20.08.2021 In addition to part-I (General Handout for all courses) printed on page | of the Timetable book, this portion gives further specific details regarding the course. Course No. : BIOF21 Course Title + Biological Chemistry Instructors : Meghana Tare, PhD (Instructor in-charge) Office + 3277-J, New Science Block Telephone Extn: X5635, Email + meghana.tare@ pilani.bits-pilani.ac.in 1 Course description: This course is intended to offer an introduction to the world of Biological Chemistry. The course deals with the structure, properties, and significance of the major groups of biochemical compounds (amino acids, proteins, carbohydrates, nucleic acids, and lipids), the bioenergetics, enzyme mechanisms and regulation of the central metabolic pathways. Efforts will be made to include the recent advances and methodologies related to biochemistry. This would help students going for higher level activities, appreciation of biochemical problems, evaluation and problem solving. 2. ‘Text Book (T) Mary K. Campbell and Shawn O. Farrell, Biochemistry, 7% edition, International edition, copyright 2012 (Thompson Brooks/Cole, Cengage Learning) 3. Reference Books (RB) a) D. Nelson & M Cox. Lehninger, Principles of Biochemistry, Palgrave, 4th Ed, b) Donald Voet et al., Biochemistry, Wiley, 1993 4, Attendance Attendance is required in order to gain understanding to various aspects of the course, Attendance will be monitored based on appearing in virtual classroom. Besides, surprise evaluation components can be held during class/tutorial hours, for which, no make-up will be given.Pilani Campus AUGS/ AGSR ion BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE, Pilani 5. Course Plan: Module i Reference name Lecture Sessions (Tentative) Learning Outcomes L1-4 Chemical nature of Biomolecules, organization of Orientation to the course and I Prokaryotes and Eukaryotes, how cells use energy 1 Introduction to Biological Chemistry LST Chemistry of carbohydrates Understanding the Carbohydrates | Structure and stereochemistry, reactions, some important T16 ‘Chemistry ‘oligosaccharides and polysaccharides and their biological roles s in, | ESL10 Nucteic acd structure, Nucleic acid chemistry, other Understanding the Biochemistry of functions of Nucleic Acids Ria) 8,79 Nucleic Acids 1y __| ELP-L14 Lipids and proteins are associated in membranes, TS Understanding the lipid structure, membrane structure functions and Biological membranes L15-L18 Amino acids and peptides, three dimensional V | structure of proteins, protein purification and characterization | 13,4,5 | Amino acids, Peptides and Proteins techniques L19-122 Classification, Enzymes Kinetics and mechanism of | 767 eam the Enzyme pes apy VI__| action, Inhibitors and regulators, Allosteric enzymes, eased caecnncheataletie Fsoenzymes action, regulation and inhibition, 125-124 Bioenergetics and thermodynamics, chemical I ‘Leam about Bioenergetics and apply itto Vit__ | and common biochemical reactions, phosphoryl groups Ria | ha about Biowserectics ang apply i iransfer and ATP, biological oxidation- reduction reactions ype s ‘Lear the (a) role(S) of glucose and other 124-127 Glycolysis, “Reversal of Glycolytic sequence Tio-T19_| isomers inthe cell and apply toward VIL | Utilization of carbohydrates, Regulation of glycolysis, Pentose utilization and production of energy: (b) phosphate pathway, Citric acid eycle, Glyoxylic acid cycle differential glucose metabolism in diseases conditions ‘Understand and learn the Oxidative ‘omponents involved in espitatory chain, ‘720. _| phosphorylation and apply to different 1X] 128-129 Components involved in ETC, Respiratory ch ‘mechanisms to produce energy in the cell ‘Apply the structural aspects of lipid 130-132 Hydrolysis and transport of fats, B-oxidation, ‘T21 | biochemistry in learning the metabolism X | Oxidation of unsaturated fatty acids, Formation of Ketone of lipids and differentiating the bodies, Biosynthesis of fatty acids. ‘metabolism in normal and diseased conditions : vain ox chway T22__ | Leam the Biochemistry involved in XI | 1334.34 Path of carbon-Calvin eycle, C4. pathway Photosynthesis in plants. xi 723 | Apply the understanding of structure of 35-140 Catabolism of amino acids, Assimilation of ammonia, Urea cycle and formation of uric acid, Purine Biosynthesis, Pyrimidine Biosynthesis, Salvage pathway. ‘Amino Acids to learn the metabolism of nitrogen; how proteins and amino acids are utilized, fate of nucleic acids in the body.BIRLA INSTITUTE OF TECHNOLOGY AND SCIENCE, Pilani Pilani Campus AUGS/ AGSR ion 6. Evaluation Scheme Please note that majority of evaluation components will be held in the online mode. (Max. Marks=200 for the course) ‘Component Duration Weightage | Date & Time | Nature of component (%) (Close Book/ Open Book) Mid Semester Test ‘90 minutes 30 CB or OB: TBD. ‘Comprehensive Examination 3h 35 PARTLY OB ‘Quizzes During tutorial 20 TBD cB hours/may be surprise ‘Assignments (In class and During tutorial ry TBD OB take home) hours/announced 7. Chamber Consultation Hour: TBD. (By appointment) 8. Notices: Put via Nalanda/Google classroom Announcements. It is mandatory to register over Google Classroom and virtual/online assessment platforms: as and when directed by IC. or, AUGSD. 9. Make-up Policy: Make up may be granted for Quizzes, only for genuine cases after verification of each case. Decision of the instructors will be final for make-up policy. 10. Notes: (A) It is mandatory to register over Google Classroom and virtual/online assessment platforms: as and when directed by IC. of, AUGSD. (B) You are requested to ensure the Connectivity at all times during the classes/evaluation components. (C) Some components can; and, will be conducted within the class hours as a surprise component. (D) Some of the components, may change subject to institutional policies (mode of teaching, mode of evaluations etc.) pertaining to pandemic situations. Your kind cooperation is requested through the semester. Meghana Tare Instructor-in-charge Course No. BIO F211