Preparation of Carboxylic Acids & Their Derivatives

CHM 4220 Organic Synthesis, Dr. Laurie S. Starkey, Cal Poly Pomona
Predict the major product(s):

Br 1) Mg Br
1) NaCN SOCl2
2) CO2
+
3) H3O+ 2) H3O pyridine

O O
1) NaOEt H3O+ heat
EtO OEt 2)
Ph Br

Provide the reagent(s):

O O

OH NH2

O O O
CH3 OH OCH3
OH

O
HO

O O O
O
O O
HO OH

Provide reagents (transform):

O O O
O

EtO OEt Ph OH O