LOVELY PROFESSIONAL

UNIVERSITY

Assignment Report
Submitted in partial fulfillment for the continuous assessment
of
FUNDAMENTALS OF RESEARCH (BTY 530)
For the degree of post-graduation of Biotechnology Hons. 2021.
Submitted By : Submitted to :
Tejaswi Harshwardhan Assisant Professor
Roll No: RB2108A88 Dr. Vijay Kumar
Registration No: 12114439
AIM AND SCOPE OF THE JOURNAL
Sr.no: Name of the Journal along with Indexing
Agency
1 Current Opinion In Biotechnology
INDEXING AGENCY: SCOPUS
2 Journal Of Biomedical Informatics
INDEXING AGENCY:SCOPUS
Aim and Scope of the Journal(100 words)
Current Opinion in Biotechnology
(COBIOT) publishes authoritative,
comprehensive, and systematic reviews.
COBIOT helps specialists keep up to date
with a clear and readable synthesis on
current advances biotechnology. Expert
authors annotate the most interesting
papers from the expanding volume of
information published today, saving
valuable time and giving the reader
insight on areas of importance.
It is divided into themed sections, each
of which is reviewed once a year. Themes
include analytical biotechnology; plant
biotechnology; food biotechnology;
energy biotechnology; environmental
biotechnology; systems biology;
nanobiotechnology; tissue, cell and
pathway engineering; chemical
biotechnology; and pharmaceutical
biotechnology.
The Journal of Biomedical Informatics
reflects a commitment to high-quality
original research papers, reviews, and
commentaries in the area of biomedical
informatics methodology. Although we
publish articles motivated by applications
in the biomedical sciences (for example,
clinical medicine, health care, population
health, and translational bioinformatics),
the journal emphasizes reports of new
methodologies and techniques that have
general applicability and that form the
basis for the evolving science of
biomedical informatics. Articles on

3 Infection And Drug Resistance
INDEXING AGENCY: WOS
medical devices; evaluations of
implemented systems (including clinical
trials of information technologies); or
papers that provide insight into a
biological process, a specific disease, or
treatment options would generally be
more suitable for publication in other
venues. Papers on applications of signal
processing and image analysis are often
more suitable for biomedical engineering
journals or other informatics journals,
although we do publish papers that
emphasize the information management
and knowledge representation/modeling
issues that arise in the storage and use of
biological signals and images. System
descriptions are welcome if they
illustrate and substantiate the underlying
methodology that is the principal focus of
the report and an effort is made to
address the generalizability and/or range
of application of that methodology. Note
also that, given the international nature
of JBI, papers that deal with specific
languages other than English, or with
country-specific health systems or
approaches, are acceptable for JBI only if
they offer generalize lessons that are
relevant to the broad JBI readership,
regardless of their country, language,
culture, or health system.
Infection and Drug Resistance is an
international, peer-reviewed, open access
journal that focuses on the optimal treatment
of infection (bacterial, fungal and viral) and
the development and institution of
preventative strategies to minimize the
development and spread of resistance.
 The journal is characterized by the rapid
reporting of high-quality original research,
reviews, guidelines, expert opinions,
commentary and clinical studies in all areas of
infection and drug resistance.

Infection and Drug Resistance will no longer

consider meta-analyses for publication.

Specific topics covered by the journal include:

• Development of novel anti-infective

• Optimal use of existing anti-infective
• Pathogenesis and etiology of
infectious disease
• Proteomic and genomic studies in
resistant organisms
• Mechanisms of resistance
development
• Vaccine development and
implementation
• Infection control in hospitals and the
community
• Diagnosis and early detection of
infection
• Clinical management of infection
• Clinical management of antibiotic
resistance (e.g. in transplant and HIV
patients)
• Epidemiology of infection and
antibiotic resistance
• Education and prevention of drug
resistance
• Patient adherence and satisfaction
4 Nature methods Nature Methods is a forum for the
publication of novel methods and
significant improvements to tried-and-
tested basic research techniques in the
INDEXING AGENCY:WOS
life sciences. This monthly publication is
aimed at a broad, interdisciplinary
audience of academic and industry
researchers actively involved in
laboratory practice. It provides them with
new tools to conduct their research and
places a strong emphasis on the
immediate practical relevance of the
work presented.

The journal publishes primary research

papers as well as overviews of recent
technical and methodological
developments. We are actively seeking
primary methods papers of relevance to
the biological and biomedical sciences,
including methods grounded in chemistry
that have a practical application to the
study of biological problems.

To enhance the practical relevance of

each paper, description of the method
must be accompanied by its validation, its
application to an important biological
question and results illustrating its
performance in comparison to available
approaches. Articles are selected for
publication that present broad interest,
thorough assessments of methodological
performance and comprehensive
technical descriptions that facilitate
immediate application.

Specific areas of interest include, but are

not limited to:

Methods for nucleic acid manipulation,

amplification and sequencing

Methods for protein engineering,

expression and purification
Methods for proteomics, including mass
spectrometry, analysis of binding
interactions, microarray-based
technologies, display techniques, analysis
of post-translational modifications,
glycobiology and metabolomics

Methods for systems biology, including

proteomics approaches, protein
interaction analysis methods and
genome wide expression and regulation
profiling

Bio-molecular structural analysis

technologies, including NMR and
crystallography

Chemical biology techniques, including

chemical labeling, methods for expanding
the genetic code and directed evolution

Biophysical methods, including single

molecule and lab-on-a-chip technologies

Optical and non-optical imaging

technologies, including probe design and
labeling methods, microscopy,
spectroscopy and in vivo imaging

Techniques for the analysis and

manipulation of gene expression,
including epigenetic, gene targeting,
transduction, RNA interference and
microarray-based technologies

Methods for cell culture and

manipulation, including stem cells, single
cell methods and lab-on-a-chip
technologies

Immunological techniques, including

production of antibodies, antibody-based
assays and immunolabeling

5 Molecular Metabolism
INDEXING AGENGY: SCOPUS
6 Current Opinion In Microbiology
INDEXING AGENCY :SCOPUS
Methods for the study of physiology and
disease processes including cancer
Methods involving model organisms and
their manipulation and phenotyping
Computational and bio-informatic
methods for analysis, modeling or
visualization of biological data
Nanotechnology-based methods applied
to basic biology
Molecular Metabolism is committed to
serving as a platform reporting breakthrough
discoveries in energy homeostasis and in the
etiology, development, treatment and
associated health consequences of metabolic
disorders, such as obesity, diabetes,
cardiovascular disease and cancer. The
journal publishes hypothesis driven research
generated with the highest standards that
paves the way to a mechanistic
understanding of energy homeostasis-
associated behavior, physiology and
dysfunction.
Molecular Metabolism reports
interdisciplinary science using approaches
ranging from molecules to man throughout
the lifespan with the potential for
transformative impact on today's metabolism
research, thereby enabling progress towards
prognosis, prevention and ultimately cure of
metabolic disorders and associated long-term
complications tomorrow.
Current Opinion in Microbiology
(COMICR) publishes authoritative,
comprehensive, and systematic reviews.
COMICR helps specialists keep up to date
with the expanding volume of
information published in the field of
microbiology. Expert authors annotate
the most interesting papers from the
expanding volume of information
published today, saving valuable time
and giving the reader insight on areas of
importance.

Current Opinion in Microbiology is part of

the Current Opinion and Research
(CO+RE) suite of journals and is a
companion to the new primary research,
open access journal, Current Research in
Microbial Sciences (CRMICR). CO+RE
journals leverage the Current Opinion
legacy of editorial excellence, high-
impact, and global reach to ensure they
are a widely read resource that is integral
to scientists' workflow.

Current Opinion in Microbiology is

divided into themed sections. It consists
of 6 issues per year covering the following
sections, each of which is reviewed once
a year:

Host-microbe interactions: bacteria

Host-microbe interactions: viruses

Host-microbe interactions: fungi

Host-microbe interactions: parasites

Cell regulation

Environmental microbiology

Microbiota

Antimicrobials

Systems and Synthetic Biology

7 Ageing Research Review
INDEXING AGENCY: WOS/SCOPUS/SCI
8 Biotechnology advances
As the average human life expectancy has
increased, so too has the impact of ageing
and age-related disease on our society.
Ageing research is now the focus of
thousands of laboratories that include
leaders in the areas of genetics,
molecular and cellular biology,
biochemistry, and behaviour. Ageing
Research Reviews (ARR) covers the
trends in this field. It is designed to fill a
large void, namely, a source for critical
reviews and viewpoints on emerging
findings on mechanisms of ageing and
age-related disease. Rapid advances in
understanding of mechanisms that
control cellular proliferation,
differentiation and survival are leading to
new insight into the regulation of ageing.
From telomerase to stem cells to energy
and oxyradical metabolism, this is an
exciting new era in the multidisciplinary
field of ageing research. The cellular and
molecular underpinnings of
manipulations that extend lifespan, such
as caloric restriction, are being identified
and novel approaches for preventing age-
related diseases are being developed.
ARR publishes articles on focused topics
selected from the broad field of ageing
research, with an emphasis on cellular
and molecular mechanisms of the aging
process and age-related diseases such as
cancer, cardiovascular disease, diabetes
and neurodegenerative disorders.
Applications of basic ageing research to
lifespan extension and disease
prevention are also covered in this
journal.
Biotechnology Advances is a review
journal which considers all aspects of the
multidisciplinary field. The scope includes

INDEXING AGENCY: SCOPUS
9 Journal Of Plant Physiology
INDEXING AGENCY: WOS/SCOPUS
biotechnology principles and applications
in industry, agriculture, medicine,
environmental concerns and regulatory
issues. Authoritative articles on current
developments and future trends in
biotechnology are empathized.
Submissions of appropriate manuscripts
are invited. A wide audience of scientists,
engineers and others is addressed:
students, instructors, researchers,
practitioners, managers, governments
and related stakeholders. Special issues
are published on selections of
presentations at recent relevant
conferences as arranged with the
organizations.
The Journal of Plant Physiology is a broad-
spectrum journal that welcomes high-
quality submissions in all major areas of
plant physiology, including plant
biochemistry, functional biotechnology,
computational and synthetic plant
biology, growth and development,
photosynthesis and respiration, transport
and translocation, plant-microbe
interactions, biotic and abiotic stress.
Studies are welcome at all levels of
integration ranging from molecules and
cells to organisms and their
environments and are expected to use
state-of-the-art methodologies. Pure
gene expression studies are not within
the focus of our journal. To be considered
for publication, papers must significantly
contribute to the mechanistic
understanding of physiological
processes, and not be merely descriptive,
or confirmatory of previous results. We
encourage the submission of papers that
explore the physiology of non-model as
well as accepted model species and those
 that bridge basic and applied research.
For instance, studies on agricultural
plants that show new physiological
mechanisms to improve agricultural
efficiency are welcome. Studies
performed under uncontrolled situations
(e.g. field conditions) not providing
mechanistic insight will not be considered
for publication.

10 Microbiological Research Microbiological Research is devoted to

publishing reports on prokaryotic and
eukaryotic microorganisms such as
INDEXING AGENCY:SCOPUS/WOS yeasts, fungi, bacteria, archaea, and
protozoa. Research on interactions
between pathogenic microorganisms and
their environment or hosts are also
covered. The research should be original
and include molecular aspects to
generate a significant contribution of
broad interest. Papers of rather
specialised or of preliminary and
descriptive content will normally not be
considered. Studies in the following
sections are included:

Reviews/Mini reviews on all aspects

Microbiology and Genetics

Molecular and Cell Biology

Metabolism and Physiology

Signal transduction and Development

Biotechnology

Phytopathology

Environmental Microbiology and Ecology

DETAILS OF CITATION INDICES OF THE JOURNAL
Sr.no: Name of the h-index H5-index JIF Cite Score SJR/IF
Journal

1 Current 176 7.934 15.1 3.675

Opinion In
Microbiology

2 Journal Of 103 6.317 8.1 1.057

Biomedical
Informatics

3 Infection And 39 2.984 3.9 1.033

Drug
Resistance

4 Nature 318 28.547 31.3 19.469

Methods

5 Molecular 65 7.422 10.7 2.848

Metabolism

6 Current 202 9.74 15.7 2.843

Opinion In
Biotechnology

7 Ageing 120 10.08 17.4 3.532

Research
Review

8 Biotechnology 191 16.301 14.227 20.6 2.772

Advances

9 Journal Of 130 3.549 6 1.032

Plant
Physiology

10 Microbiological 5.415 7.5

Research
DETAILS OF MOST CITED PAPER OF THE JOURNAL
Sr.no Name of The Journal Title of Most Cited Abstract of Most Cited
Papers Papers

1 Molecular metabolism Glucagon-like peptide 1 The glucagon-like peptide

1 (GLP-1) is a multifaceted
(GLP-1)
hormone with broad
pharmacological
potential. Among the
numerous metabolic
effects of GLP-1 are the
glucose-dependent
stimulation of insulin
secretion, decrease of
gastric emptying,
inhibition of food intake,
increase of natriuresis and
diuresis, and modulation
of rodent β-cell
proliferation. GLP-1 also
has cardio- and
neuroprotective effects,
decreases inflammation
and apoptosis, and has
implications for learning
and memory, reward
behavior, and palatability.
Biochemically modified
for enhanced potency and
sustained action, GLP-1
receptor agonists are
successfully in clinical use
for the treatment of type-
2 diabetes, and several
GLP-1-based
pharmacotherapy are in
clinical evaluation for the
treatment of obesity.

2 Infection And Drug Cerebral malaria: insight Cerebral malaria is a

Resistance medical emergency. All
into pathogenesis,
patients with Plasmodium
complications and falciparum malaria with
molecular biomarkers neurologic manifestations
 of any degree should be
urgently treated as cases
of cerebral malaria.
Pathogenesis of cerebral
malaria is due to damaged
vascular endothelium by
parasite sequestration,
inflammatory cytokine
production and vascular
leakage, which result in
brain hypoxia, as indicated
by increased lactate and
alanine concentrations.
The levels of the
biomarkers’ histidine-rich
protein II, angiopoietin-
Tie-2 system and plasma
osteoprotegrin serve as
diagnostic and prognostic
markers. Brain imaging
may show
neuropathology around
the caudate and putamen.
Mortality is high and
patients who survive
sustain brain injury which
manifests as long-term
neurocognitive
impairments.

3 Nature Methods Fast animal pose The need for

estimation using deep automated and efficient
neural networks systems for tracking full
animal pose has
increased with the
complexity of
behavioral data and
analyses. Here we
introduce LEAP (LEAP
estimates animal pose),
a deep-learning-based
method for predicting
the positions of animal
body parts. This
 framework consists of a
graphical interface for
labeling of body parts
and training the
network. LEAP offers
fast prediction on new
data, and training with
as few as 100 frames
results in 95% of peak
performance. We
validated LEAP using
videos of freely
behaving fruit flies and
tracked 32 distinct
points to describe the
pose of the head, body,
wings and legs, with an
error rate of <3% of
body length. We
recapitulated reported
findings on insect gait
dynamics and
demonstrated LEAP’s
applicability for
unsupervised
behavioral
classification. Finally,
we extended the
method to more
challenging imaging
situations and videos of
freely moving mice.

4 Biotechnology Metabolic engineering Biotechnology

Advances of microbes for Advances is a review
monoterpenoid journal which considers
production all aspects of the
multidisciplinary field.
The scope includes
biotechnology
principles and
applications in industry,
 agriculture, medicine,
environmental
concerns and regulatory
issues. Authoritative
articles on current
developments and
future trends in
biotechnology are
empathized.
Submissions of
appropriate
manuscripts are invited.
A wide audience of
scientists, engineers
and others is addressed:
students, instructors,
researchers,
practitioners,
managers,
governments and
related stakeholders.
Special issues are
published on selections
of presentations at
recent relevant
conferences as
arranged with the
organizations.

5 Current Opinion in Antifungal drug Microorganisms have a

Microbiology resistance: evolution, remarkable capacity to
mechanisms and evolve resistance to
impact antimicrobial agents,
threatening the efficacy
of the limited arsenal of
antimicrobials and
becoming a dire public
health crisis. This is of
particular concern for
fungal pathogens,
which cause
devastating invasive
 infections with
treatment options
limited to only three
major classes of
antifungal drugs. The
paucity of antifungals
with clinical utility is in
part due to close
evolutionary
relationships between
these eukaryotic
pathogens and their
human hosts, which
limits the unique
targets to be exploited
therapeutically. This
review highlights the
mechanisms by which
fungal pathogens of
humans evolve
resistance to antifungal
drugs, which provide
crucial insights to
enable development of
novel therapeutic
strategies to thwart
drug resistance and
combat fungal
infectious disease.

6 Ageing Research Aging in COVID-19: The severe acute

Review Vulnerability, immunity respiratory syndrome
and intervention coronavirus-2 (SARS-
CoV-2) pandemic was
first reported in Wuhan,
China in December
2019, moved across the
globe at an
unprecedented speed,
and is having a
profound and yet still
unfolding health and
socioeconomic impacts.
SARS-CoV-2, a β-
coronavirus, is a highly
contagious respiratory
pathogen that causes a
disease that has been
termed the 2019
coronavirus disease
(COVID-19). Clinical
experience thus far
indicates that COVID-19
is highly
heterogeneous, ranging
from being
asymptomatic and mild
to severe and causing
death. Host factors
including age, sex, and
co morbid conditions
are key determinants of
disease severity and
progression. Aging itself
is a prominent risk
factor for severe
disease and death from
COVID-19. We
hypothesize that age-
related decline and
dysregulation of
immune function, i.e.,
immuno-senescence
and inflamm-aging play
a major role in
contributing to
heightened
vulnerability to severe
COVID-19 outcomes in
older adults. Much
remains to be learned
about the immune
responses to SARS-CoV-
 2 infection. We need to
begin partitioning all
immunological
outcome data by age to
better understand
disease heterogeneity
and aging. Such
knowledge is critical not
only for understanding
of COVID-19
pathogenesis but also
for COVID-19 vaccine
development.

7 Current Opinion In Functions and emerging Bacteriocins, defined as

Biotechnology applications of ribosomaly synthesized
bacteriocins antimicrobial peptides,
have traditionally been
used as food
preservatives, either
added or produced by
starter cultures during
fermentation. In-depth
studies of a select few
bacteriocins opened
exiting new research
fields and broadened
the application of these
antimicrobial peptides.
The possibility of
developing bacteriocins
into next generation
antibiotics,
accompanied with the
rapid development in
genetics and
nanotechnology, paves
the way to even more
fascinating applications
such as novel carrier
molecules (delivery
systems) and the
 treatment of cancer.
Also, some bacteriocins
are found to regulate
quorum sensing which
suggests novel
applications for this
group of substances.
While there is some
interesting translational
research on
bacteriocins from
Gram-negative
bacteria, the majority of
application-oriented
studies are focused on
bacteriocins from
Gram-positive
microorganisms, mostly
lactic acid bacteria. The
applications of
bacteriocins are
expanding from food to
human health.

8 Journal of Plant Dynamic changes in the Starch is a significant

Physiology starch-sugar inter- store of sugars, and the
conversion within plant starch-sugar inter-
source and sink tissues conversion in source
promote a better and sink tissues plays a
abiotic stress response profound physiological
role in all plants. In this
review, we discuss how
changes in starch
metabolism can
facilitate adaptive
changes in source-sink
carbon allocation for
protection against
environmental stresses.
The stress-related roles
of starch are described,
and published
mechanisms by which
starch metabolism
responds to short- or
long-term water deficit,
salinity, or extreme
temperatures are
discussed. Numerous
examples of starch
metabolism as a stress
response are also
provided, focusing on
studies where
carbohydrates and
cognate enzymes were
assayed in source, sink,
or both. We develop a
model that integrates
these findings with the
theoretical and known
roles of sugars and
starch in various
species, tissues, and
developmental stages.
In this model, localized
starch degradation into
sugars is vital to the
plant cold stress
response, with the
sugars produced
providing osmo-
protection. In contrast,
high starch
accumulation is
prominent under
salinity stress, and is
associated with higher
assimilate allocation
from source to sink. Our
model explains how
starch-sugar inter-
conversion can be a
 convergent point for
regulating carbon use in
stress tolerance at the
whole-plant level.

9 Journal Of Biomedical The REDCap The Research Electronic

Informatics consortium: Building an Data Capture (REDCap)
international data management
community of software platform was
platform partners developed in 2004 to
address an institutional
need at Vanderbilt
University and then
shared with a limited
number of adopting
sites beginning in 2006.
Given bi-directional
benefit in early sharing
experiments, we
created a broader
consortium sharing and
support model for any
academic, non-profit, or
government partner
wishing to adopt the
software. Our sharing
framework and
consortium-based
support model have
evolved over time along
with the size of the
consortium (currently
more than 3200
REDCap partners across
128 countries). While
the “REDCap
Consortium” model
represents only one
example of how to build
and disseminate a
software platform,
lessons learned from
 our approach may assist
other research
institutions seeking to
build and disseminate
innovative
technologies.

10 Microbiological Revitalization of plant The progression of life

Research growth promoting in all forms is not only
rhizobacteria for dependent on
sustainable agricultural and food
development in security but also on the
agriculture soil characteristics. The
dynamic nature of soil is
a direct manifestation
of soil microbes, bio-
mineralization, and
synergistic co-evolution
with plants. With the
increase in world’s
population the demand
for agriculture yield has
increased tremendously
and thereby leading to
large scale production
of chemical fertilizers.
Since the use of
fertilizers and pesticides
in the agricultural fields
have caused
degradation of soil
quality and fertility,
thus the expansion of
agricultural land with
fertile soil is near
impossible, hence
researchers and
scientists have shifted
their attention for a
safer and productive
means of agricultural
practices. Plant growth
promoting
rhizobacteria (PGPR)
has been functioning as
a co-evolution between
plants and microbes
showing antagonistic
and synergistic
interactions with
microorganisms and the
soil. Microbial
revitalization using
plant growth promoters
had been achieved
through direct and
indirect approaches like
bio-fertilization,
invigorating root
growth,
rhizoremediation,
disease resistance etc.
Although, there are a
wide variety of PGPR
and its allies, their role
and usages for
sustainable agriculture
remains controversial
and restricted. There is
also variability in the
performance of PGPR
that may be due to
various environmental
factors that might affect
their growth and
proliferation in the
plants. These gaps and
limitations can be
addressed through use
of modern approaches
and techniques such as
nano-encapsulation
and micro-
encapsulation along
with exploring
multidisciplinary
research that combines
applications in
biotechnology,
nanotechnology, agro
biotechnology,
chemical engineering
and material science
and bringing together
different ecological and
functional biological
approaches to provide
new formulations and
opportunities with
immense potential.