ABO INCOMP - Blood transfusion

- Surgery
- mother with blood type O becomes
- Blood type of parents (if newborn
pregnant with a fetus with a different
ang case)
blood type (type A, B, or AB). The
mother's serum contains naturally - History of the same presentation to
occurring anti-A and anti-B, cross siblings (if not panganay si baby)
the placenta and hemolyse fetal
RBCs
TX

NASACORNE Hemolytic disease of the newborn - treat

History and Physical Exam– OPQRST
Hemolytic disease of the fetus and newborn
– severely anemic newborns, which involves
- previous pregnancies with hydrops
fetalis
- miscarriages
- ectopic pregnancies
- early pregnancy terminations
- blood transfusions in the mother
- documentation of bleeding in
pregnancy.
- anemia and hyperbilirubinemia
hyperbilirubinemia with phototherapy and
exchange transfusions if needed.
(An exchange transfusion may be needed for
replacing infant RBCs with antigen-negative
RBCs, thereby preventing further
hemolysis.)
Anemic infants may require blood
transfusions with ABO-matched packed
RBCs. If immediate transfusion is thought
to be needed, O-type, Rh-negative blood
should be available at delivery.
Intravenous immunoglobulin (IVIG) in
the infant may block Fc receptors on
macrophages, thereby decreasing the
breakdown of antibody-coated RBCs.

- lethargy
- jaundice
- conjunctival icterus
- pallor
- hepatosplenomegaly
- tachycardia or bradycardia
- increased oxygen requirement,
and/or apnea

Also consider-