HEMOGLOBINA:

ATG GTG CAC CTG ACT CCT GAG GAG AAG TCT GCC GTT ACT GCC CTG TGG GGC AAG
GTG AAC GTG GAT GAA GTT GGT GGT GAG GCC CTG GGC AGG CTG CTG GTG GTC TAC
CCT TGG ACC CAG AGG TTC TTT GAG TCC TTT GGG GAT CTG TCC ACT CCT GAT GCT GTT
ATG GGC AAC CCT AAG GTG AAG GCT CAT GGC AAG AAA GTG CTC GGT GCC TTT AGT GAT
GGC CTG GCT CAC CTG GAC AAC CTC AAG GGC ACC TTT GCC ACA CTG AGT GAG CTG
CAC TGT GAC AAG CTG CAC GTG GAT CCT GAG AAC TTC AGG

mvhltpeeks avtalwgkvn vdevggealg rllvvypwtq rffesfgdls tpdavmgnpk

vkahgkkvlg afsdglahld nlkgtfatls elhcdklhvd penfr

SECUENCIA DE LA PROTEINA HEMOGLOBINA EN EL PACIENTE 1

ATG GTG CAC CTG ACT CCT GAA GAG AAG TCT CGG GTT ACT GCC CTC AGG GGC AAG
GTG AAT GTG AAA GAA GTT GGT AAC GAG GGG CTG GGC AGG CTG CTG GAA ATC TAC
CCT TGG ACC CAG AGC TTC TTT GAG TCC TTT GGG GAT CTG TCC ACT CCT GAT GCT GTT
ATG GGC AAC CCT AAG GTG AAG GCT CAT GGC AAG AAA GTG CTC GGT GCC AAA AGT GAT
GGC CTG GCT CAC CTG GAC AAC CTC AAG GGC ACC TTT GCC ACA CTG AGT GAG CTG
CAC TGT GAC AAG CTG CAC GTG GAT CCT GAG AAC TTC AGG

O ATG GTG CAC CTG ACT CCT GAG GAG AAG TCT GCC GTT ACT GCC CTG TGG GGC AAG
GTG
P1ATG GTG CAC CTG ACT CCT GAA GAG AAG TCT CGG GTT ACT GCC CTC AGG GGC AAG
GTG
e r l r
m v h l t p e e k s a v t a l w g k
v

OAAC GTG GAT GAA GTT GGT GGT GAG GCC CTG GGC AGG CTG CTG GTG GTC TAC CCT
TGG
P1AAT GTG AAA GAA GTT GGT AAC GAG GGG CTG GGC AGG CTG CTG GAA ATC TAC CCT
TGG
n k n g e l
n v d e v g g e a l g r l l v v y p
w

O ACC CAG AGG TTC TTT GAG TCC TTT GGG GAT CTG TCC ACT CCT GAT GCT GTT ATG
GGC
P1 ACC CAG AGC TTC TTT GAG TCC TTT GGG GAT CTG TCC ACT CCT GAT GCT GTT ATG
GGC
s
t q r f f e s f g d l s t p d a v m g

O AAC CCT AAG GTG AAG GCT CAT GGC AAG AAA GTG CTC GGT GCC TTT AGT GAT GGC
CTG
P1AAC CCT AAG GTG AAG GCT CAT GGC AAG AAA GTG CTC GGT GCC AAA AGT GAT GGC
CTG
k
n p k v k a h g k k v l g a f s d g l
O GCT CAC CTG GAC AAC CTC AAG GGC ACC TTT GCC ACA CTG AGT GAG CTG CAC TGT
GAC
P1GCT CAC CTG GAC AAC CTC AAG GGC ACC TTT GCC ACA CTG AGT GAG CTG CAC TGT
GAC

a h l d n l k g t f a t l s e l h c
d

O AAG CTG CAC GTG GAT CCT GAG AAC TTC AGG
P1 AAG CTG CAC GTG GAT CCT GAG AAC TTC AGG

k l h v d p e n f r

SECUENCIA DE LA PROTEINA HEMOGLOBINA EN EL PACIENTE 2

ATG GTG CAT CTG ACT CCT GAG GAG AAG TCT GCC GTT ACT GCC CTG TGA GGC AAG GTG
AAC GTG GAT GAA GTT GGT GGT GAG GCC CTG GGC AGG CTG CTG GTG GTC TAC CCT
TGG ACC CAG AGG TTC TTT GAG TCC TTT GGG GAT CTG TCC ACT CCT GAT GCT GTT ATG
GGC AAC CCT AAG GTG AAG GCT CAT GGC AAG AAA GTG CTC GGT GCC TTT AGT GAT GGC
CTG GCT CAC CTG GAC AAC CTC AAG GGC ACC TTT GCC ACA CTG AGT GAG CTG CAC TGT
GAC AAG CTG CAC GTG GAT CCT GAG AAC TTC AGG

O ATG GTG CAC CTG ACT CCT GAG GAG AAG TCT GCC GTT ACT GCC CTG TGG GGC AAG
P2 ATG GTG CAT CTG ACT CCT GAG GAG AAG TCT GCC GTT ACT GCC CTG TGA GGC AAG
h stop
m v h l t p e e k s a v t a l w g k

O GTG AAC GTG GAT GAA GTT GGT GGT GAG GCC CTG GGC AGG CTG CTG GTG GTC TAC
P2 GTG AAC GTG GAT GAA GTT GGT GGT GAG GCC CTG GGC AGG CTG CTG GTG GTC TAC

v n v d e v g g e a l g r l l v v y

O CCT TGG ACC CAG AGG TTC TTT GAG TCC TTT GGG GAT CTG TCC ACT CCT GAT GCT
GTT
P2CCT TGG ACC CAG AGG TTC TTT GAG TCC TTT GGG GAT CTG TCC ACT CCT GAT GCT
GTT

p w t q r f f e s f g d l s t p d a v

O ATG GGC AAC CCT AAG GTG AAG GCT CAT GGC AAG AAA GTG CTC GGT GCC TTT AGT
GAT
P2 ATG GGC AAC CCT AAG GTG AAG GCT CAT GGC AAG AAA GTG CTC GGT GCC TTT AGT
GAT

m g n p k v k a h g k k v l g a f s d
O GGC CTG GCT CAC CTG GAC AAC CTC AAG GGC ACC TTT GCC ACA CTG AGT GAG CTG
P2 GGC CTG GCT CAC CTG GAC AAC CTC AAG GGC ACC TTT GCC ACA CTG AGT GAG CTG

g l a h l d n l k g t f a t l s e l

O CAC TGT GAC AAG CTG CAC GTG GAT CCT GAG AAC TTC AGG
P2 CAC TGT GAC AAG CTG CAC GTG GAT CCT GAG AAC TTC AGG

h c d k l h v d p e n f r

SECUENCIA DE LA PROTEINA HEMOGLOBINA EN EL PACIENTE 3

ATG GTG CAC CTG ACT CCT GAG GAG AAG TCT GCC ACG TTA CTG CCC TGT GGG GCA
AGG TGA ACG TGG ATG AAG TTG GTG GTG AGG CCC TGG GCA GGC TGC TGG TGG TCT
ACC CTT GGA CCC AGA GGT TCT TTG AGT CCT TTG GGG ATC TGT CCA CTC CTG ATG CTG
TTA TGG GCA ACC CTA AGG TGA AGG CTC ATG GCA AGA AAG TGC TCG GTG CCT TTA GTG
ATG GCC TGG CTC ACC TGG ACA ACC TCA AGG GCA CCT TTG CCA CAC TGA GTG AGC TGC
ACT GTG ACA AGC TGC ACG TGG ATC CTG AGA ACT TCA GG

O ATG GTG CAC CTG ACT CCT GAG GAG AAG TCT GCC GTT ACT GCC CTG TGG GGC AAG
P3ATG GTG CAC CTG ACT CCT GAG GAG AAG TCT GCC AC GTT ACT GCC CTG TGG GGC
AAG
Adición
m v h l t p e e k s a v t a l w g k

O GTG AAC GTG GAT GAA GTT GGT GGT GAG GCC CTG GGC AGG CTG CTG GTG GTC TAC
P3 GTG AAC GTG GAT GAA GTT GGT GGT GAG GCC CTG GGC AGG CTG CTG GTG GTC TAC

v n v d e v g g e a l g r l l v v y

O CCT TGG ACC CAG AGG TTC TTT GAG TCC TTT GGG GAT CTG TCC ACT CCT GAT GCT
C CTT TGG ACC CAG AGG TTC TTT GAG TCC TTT GGG GAT CTG TCC ACT CCT GAT GCT
Falta
p w t q r f f e s f g d l s t p d a

O GTT ATG GGC AAC CCT AAG GTG AAG GCT CAT GGC AAG AAA GTG CTC GGT GCC TTT
P3 GTT ATG GGC AAC CCT AAG GTG AAG GCT CAT GGC AAG AAA GTG CTC GGT GCC TTT

v m g n p k v k a h g k k v l g a f

O AGT GAT GGC CTG GCT CAC CTG GAC AAC CTC AAG GGC ACC TTT GCC ACA CTG AGT
P3 AGT GAT GGC CTG GCT CAC CTG GAC AAC CTC AAG GGC ACC TTT GCC ACA CTG AGT

s d g l a h l d n l k g t f a t l s
O GAG CTG CAC TGT GAC AAG CTG CAC GTG GAT CCT GAG AAC TTC AGG
P3 GAG CTG CAC TGT GAC AAG CTG CAC GTG GAT CCT GAG AAC TTC AGG

e l h c d k l h v d p e n f r

SECUENCIA DE LA PROTEINA HEMOGLOBINA EN EL PACIENTE 4

ATG GTA CAC CTG ACT TGA GGA GAA GTC TGC CGT TAC TGC CCT GGG GGC AAG GTG
AAC GTG GAT GAA GTT GTG GTG AGG CCC TGG GCA GGC TGC TGG TGG TCT ACC CTT
GGA CCC AGA GGT TCT TTG AGT CCT TTG GGG ATC TGT CCA CTC CTG ATG CTG TTA TGG
GCA ACC CTA AGG TGA AGG CTC ATG GCA AGA AAG TGC TCG GTG CCT TTA GTG ATG GCC
TGG CTC ACC TGG ACA ACC TCA AGG GCA CCT TTG CCA CAC TGA GTG AGC TGC ACT GTG
ACA AGC TGC ACG TGG ATC CTG AGA ACT TCA GG

O ATG GTG CAC CTG ACT CCT GAG GAG AAG TCT GCC GTT ACT GCC CTG TGG GGC AAG
P4 ATG GTA CAC CTG ACT T GAG GAG AAG TCT GCC GTT ACT GCC CTG GGG GCA A G
v Falta g a Falta
m v h l t p e e k s a v t a l w g k

O GTG AAC GTG GAT GAA GTT GGT GGT GAG GCC CTG GGC AGG CTG CTG GTG GTC TAC
P4 GTG AAC GTG GAT GAA GTT GgT GGT GAG GCC CTG GGC AGG CTG CTG GTG GTC TAC
Falta
v n v d e v g g e a l g r l l v v y

O CCT TGG ACC CAG AGG TTC TTT GAG TCC TTT GGG GAT CTG TCC ACT CCT GAT GCT
GTT
P4 CCT TGG ACC CAG AGG TTC TTT GAG TCC TTT GGG GAT CTG TCC ACT CCT GAT GCT
GTT

p w t q r f f e s f g d l s t p d a v

O ATG GGC AAC CCT AAG GTG AAG GCT CAT GGC AAG AAA GTG CTC GGT GCC TTT AGT
GAT
P4 ATG GGC AAC CCT AAG GTG AAG GCT CAT GGC AAG AAA GTG CTC GGT GCC TTT AGT
GAT

m g n p k v k a h g k k v l g a f s
d

O GGC CTG GCT CAC CTG GAC AAC CTC AAG GGC ACC TTT GCC ACA CTG AGT GAG CTG
P4 GGC CTG GCT CAC CTG GAC AAC CTC AAG GGC ACC TTT GCC ACA CTG AGT GAG CTG
 g l a h l d n l k g t f a t l s e l

O CAC TGT GAC AAG CTG CAC GTG GAT CCT GAG AAC TTC AGG
P4 CAC TGT GAC AAG CTG CAC GTG GAT CCT GAG AAC TTC AGG

h c d k l h v d p e n f r