Cannabis Could Hold the Key to Preventing Neurodegenerative Diseases

Like Parkinson’s and Alzheimer’s

By Good News Network - Feb 8, 2022

Cannabis could hold the key to preventing neurodegenerative diseases like Parkinson’s and Alzheimer’s, as it
contains a chemical that protects brain cells against aging, according to new research.

What’s more, the ‘miracle compound’ CBN (cannabinol) is non-psychoactive. In other words, it doesn’t get
people high.

Senior author Professor Pamela Maher said, “We’ve found cannabinol protects neurons from oxidative
stress and cell death—two of the major contributors to Alzheimer’s.

“This discovery could one day lead to the development of new therapeutics for treating this disease and
other neuro-degenerative disorders—like Parkinson’s disease.”

Studies on medical cannabis have focused on the active substances THC (delta-9 tetrahydrocannabinol)
and CBD (cannabidiol).

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Little is known about the therapeutic powers of CBN—which is molecularly similar but less heavily regulated.

The team at The Salk Institute in California previously identified the neuro-protective properties. Now they
have worked out the mechanism.
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Lab experiments showed CBN stops a type of cell death called oxitosis. The process is triggered by the loss
of an antioxidant called glutathione.

In experiments, nerve cells were treated with CBN—before oxidative damage was stimulated.

Further analysis found CBN boosted mitochondria—the power stations of cells.

In damaged neurons, oxidation caused them to curl up like donuts—a change that’s been seen in the brains
of people with Alzheimer’s.

Impregnating cells with CBN maintained their healthy shape—and kept them functioning well.

When the test was replicated in nerve cells with mitochondria removed, CBN was no longer effective—
confirming the finding.

RELATED: U.S. DEA is Finally Allowing Companies to Grow Their Own Cannabis for Scientific Research

Prof Maher said, “We were able to directly show maintenance of mitochondrial function was specifically
required for the protective effects of the compound.”

The study also showed CBN did not activate cannabinoid receptor—which happens during a psychoactive
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response.

So medications containing it would work without causing the individual to become ‘high.’
First author Dr Zhibin Liang said,”CBN is not a controlled substance like THC—the psychotropic compound in
cannabis.

“Evidence has shown CBN is safe in animals and humans. And because CBN works independently of
cannabinoid receptors, it could also work in a wide variety of cells with ample therapeutic potential.”

The study has implications for a range of neuro-degenerative diseases such as Parkinson’s—which is also
linked to glutathione loss.

LOOK: Georgia Lab Experiments Shows CBD Reduces Plaque And Improves Cognition in Early Onset
Alzheimer’s

Prof Maher said, “Mitochondrial dysfunction is implicated in changes in various tissues—not just in the brain
and aging.

“So the fact this compound is able to maintain mitochondrial function suggests it could have more benefits
beyond the context of Alzheimer’s disease.”

She called for further research into CBN and other lesser-studied cannabinoids in the marijuana plant.

Prof Maher and colleagues are now seeing if they can reproduce the results in a pre-clinical mouse model.

The study is in Free Radical Biology and Medicine.

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