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  • Forensic Analysis of Explosives by LC/MS.: Author Information

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    KAVITA HOODA
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    This document discusses the use of liquid chromatography/mass spectrometry (LC/MS) for forensic analysis of explosives. LC/MS combines good separation capabilities with highly sensitive and specific detection, making it well-suited for trace analysis of explosives. Electrospray ionization (ESI)-LC/MS in negative ion mode is particularly effective, producing adduct and [M - H]- ions from explosives with detection limits in the picogram range. The document describes the principles and instrumentation of various LC/MS interfaces and ionization modes for forensic analysis of explosives.

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    2001-1

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    This document discusses the use of liquid chromatography/mass spectrometry (LC/MS) for forensic analysis of explosives. LC/MS combines good separation capabilities with highly sensitive and specific detection, making it well-suited for trace analysis of explosives. Electrospray ionization (ESI)-LC/MS in negative ion mode is particularly effective, producing adduct and [M - H]- ions from explosives with detection limits in the picogram range. The document describes the principles and instrumentation of various LC/MS interfaces and ionization modes for forensic analysis of explosives.

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    © All Rights Reserved
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    15 views1 page

    Forensic Analysis of Explosives by LC/MS.: Author Information

    Uploaded by

    KAVITA HOODA
    This document discusses the use of liquid chromatography/mass spectrometry (LC/MS) for forensic analysis of explosives. LC/MS combines good separation capabilities with highly sensitive and specific detection, making it well-suited for trace analysis of explosives. Electrospray ionization (ESI)-LC/MS in negative ion mode is particularly effective, producing adduct and [M - H]- ions from explosives with detection limits in the picogram range. The document describes the principles and instrumentation of various LC/MS interfaces and ionization modes for forensic analysis of explosives.

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    © All Rights Reserved
    Download as DOCX, PDF, TXT or read online from Scribd
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    https://europepmc.

    org/article/med/26256142

    Forensic Analysis of Explosives by LC/MS.


    Yinon Y1

    Author information
    Forensic Science Review, 01 Jan 2001, 13(1):19-28
    PMID: 26256142 
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    Abstract 

    Liquid chromatography/mass spectrometry (LC/MS), combining good separation


    characteristics with highly specific and sensitive detection, is the method of choice for
    forensic trace analysis of explosives. Principles of operation and instrumentation of
    several LC/MS interface/ionization modes are described. Among the various LC/MS
    interfaces and ionization modes, electrospray ionization (ESI)-LC/MS in the negative-ion
    mode was found to be the most suitable for analysis and identification of trace amounts
    of explosives. Characteristic electrospray ions of explosives are mainly adduct and [M -
    H]- ions. Detection limits in ESI-LC/MS of the investigated explosives were found to be in
    the pg rang

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