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    This document summarizes a study examining whether early increases in high-sensitivity cardiac troponin (hs-TnT) can predict mortality in cancer patients undergoing chemotherapy. The study found that hs-TnT levels increased more than twofold in 38 patients and more than fourfold in 37 patients. A rise in hs-TnT was most commonly seen at the 3-month follow-up. The study concluded that an early increase in hs-TnT of more than 10 pg/ml between baseline and the 3-month follow-up predicted mortality and represented a predictor of death.

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    This document summarizes a study examining whether early increases in high-sensitivity cardiac troponin (hs-TnT) can predict mortality in cancer patients undergoing chemotherapy. The study found that hs-TnT levels increased more than twofold in 38 patients and more than fourfold in 37 patients. A rise in hs-TnT was most commonly seen at the 3-month follow-up. The study concluded that an early increase in hs-TnT of more than 10 pg/ml between baseline and the 3-month follow-up predicted mortality and represented a predictor of death.

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    7 views1 page

    pc724 2867

    Uploaded by

    Shahenda Shawky
    This document summarizes a study examining whether early increases in high-sensitivity cardiac troponin (hs-TnT) can predict mortality in cancer patients undergoing chemotherapy. The study found that hs-TnT levels increased more than twofold in 38 patients and more than fourfold in 37 patients. A rise in hs-TnT was most commonly seen at the 3-month follow-up. The study concluded that an early increase in hs-TnT of more than 10 pg/ml between baseline and the 3-month follow-up predicted mortality and represented a predictor of death.

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    Cardiovascular Disease in Special Populations – Cardio-Oncology 2867

    Early increase of high-sensitivity cardiac troponin predicts mortality in cancer patients undergoing
    chemotherapy
    M.A. Nowakowska 1 , L. Chrzanowski 1 , D. Miskowiec 1 , K. Wdowiak-Okrojek 1 , P. Wejner-Mik 1 , P. Lipiec 1 , M. Krakowska 1 , P. Potemski 1 ,
    E. Plonska-Gosciniak 2 , J.D. Kasprzak 2
    1
    Medical University of Lodz, Lodz, Poland; 2 Pomeranian Medical University, Szczecin, Poland
    Funding Acknowledgement: Type of funding sources: None.

    Downloaded from https://academic.oup.com/eurheartj/article/42/Supplement_1/ehab724.2867/6392497 by guest on 24 February 2022


    Introduction: High-sensitivity cardiac troponin test (hs-TnT) reveals sub- 30% with trastuzumab, 54% with hormone therapy, 71% with radiother-
    clinical myocardial damage in many cardiac conditions. We hypothesized apy. A significant decrease of LVEF were observed during follow-up (LVEF
    that elevated hs-TnT may predict a development of cancer therapy-related at baseline, 3, 6 and 12 months: 61.7±2.0%; 60.9±2.0%*; 60.8±2.9%*;
    cardiac dysfunction and clinical outcomes linked with antineoplastic ther- 59.9±2.9%*; *p<0.05 vs baseline). A significant reduction of global lon-
    apies. We aimed to evaluate the predictive value of hs-TnT for all-cause gitudinal strain was found only at 6-month follow-up (−19,2±2,2% vs
    mortality in a group of patients (pts) with recent diagnosis of cancer. −18,6±2,0%; p=0,003). In 38 pts at least a twofold (fourfold in37) increase
    Material and methods: We included 80 pts (mean age 57±13 years; 98% in hs-TnT >99th percentile was observed. A rise of hs-TnT was most often
    women) with recently diagnosed cancer (78 breast cancer, 1 colon cancer, seen at 3 month (n=35; 43,8%). During median 1056 (221–1906) days off
    1 DLBCL lymphoma). Transthoracic echocardiography and hs-TnT tests follow-up 18 (24%) pts died and ROC curve analysis revealed that early
    were performed at baseline and after 3, 6 and 12-months. Pts with LVEF (0–3 months) hs-TnT increase more than 10 pg/ml [AUC=0,693 (0,545–
    <50% and significant valvular disease were excluded. 0,806); p=0,017)] represented a predictor of death [OR=3,4 (1,99–11,87)].
    Results: In the study group 44% pts had arterial hypertension, 54% dys- Conclusions: Increase in hs-TnT in cancer patients detected at 3rd month
    lipidemia, 9% diabetes mellitus; 94% pts were treated with anthracyclines, of chemotherapy predicts mortality.

    Figure 1

    ESC Congress 2021 – The Digital Experience


    27– 30 August 2021

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