Gordon Research Conferences - 2011 Program - Bones & Teeth http://www.grc.org/programs.aspx?

year=2011&program=bones

Gordon Research Conferences

Bones & Teeth

Evolutionary and Developmental Mechanisms of Skeletal and Tooth Biology and Disease

June 19-24, 2011

Les Diablerets Conference Center
Les Diablerets, Switzerland

Chair:
Bjorn R. Olsen

Vice Chair:
Brendan Lee

Application Deadline

The application deadline for this meeting was May 22, 2011. You may still submit an application. However, it will only be
considered by the Conference Chair if more seats become available due to cancellations.

Related Meeting Information

The Bones & Teeth Gordon Research Conference will be held in conjunction with the Bones & Teeth Gordon Research
Seminar. Those interested in attending both meetings must submit an application for the GRS in addition to an application for
the GRC. Please refer to the Bones & Teeth GRS web page for more information.

The 2011 Gordon Research Conference (GRC) on “Bones & Teeth” will be focused on cellular and molecular aspects of
skeletal biology and pathology in the context of evolutionary and developmental principles and mechanisms. The Program will
include sessions on Evolution of Bones and Teeth, Developmental and Genetic Mechanisms, Postnatal Homeostasis, Stem
Cells and Regenerative Medicine/Dentistry, Osteoporosis, Cancer, as well as Joints and Soft Tissue Connections of Bones and
Teeth. The meeting will conclude with a keynote session on Evolutionary Gain and Loss of Skeletal Elements. The sessions,
chaired by leaders in the field, will foster discussion among invited speakers and other senior and junior investigators, students
and post-docs in a collegiate atmosphere. Some poster presentations will be selected for short talks. The programmed talks,
discussions, poster presentations and more informal gatherings in the afternoon and evenings will provide avenues for scientists
from different disciplines to brainstorm about skeletal structure and function in health and disease, stimulate ideas about
development of new therapeutic strategies for diseases of bones and teeth, and promote cross-disciplinary collaborations in the
various research areas represented.

The GRC will be preceded by a two-day Gordon Research Seminar (GRS) on “Cell Niche Microenvironments in Bone and
Tooth Development and Regeneration”. This is a unique forum for graduate students, post-docs and other scientists with
comparable levels of experience and education to present and exchange new data and cutting edge ideas. The Seminar will
explore the rapidly advancing fields of stem/progenitor cell biology, differentiation, transdifferentiation and reprogramming, in the
context of the cell niche/microenvironment and its effects on bone and tooth development and regeneration. Topics of interest
include, but are not limited to, craniofacial evolution and genetics, molecular mechanisms of differentiation, cell-matrix
interactions, tissue morphogenesis and regeneration, stem cell applications, and development of skeletal diseases. The meeting
will feature talks and poster sessions. All attendees are expected to actively participate in the GRS either by giving an oral
presentation or presenting a poster and to remain for the whole of the subsequent GRC.

Note: All speakers selected for oral presentations based on submitted abstracts should bring their posters to the meeting so
that discussion of their projects can continue during the poster sessions.

1 of 6 5/25/2011 5:27 AM
Gordon Research Conferences - 2011 Program - Bones & Teeth http://www.grc.org/programs.aspx?year=2011&program=bones

Contributors

SUNDAY
4:00 pm - 8:00 pm Arrival and Check-in (Check-in Desk Closed 6:00 pm - 7:45 pm)
6:00 pm Dinner
7:30 pm - 7:40 pm Welcome / Introductory Comments by Conference Chairs and GRC Site Staff
7:40 pm - 9:30 pm EVOLUTION OF BONES AND TEETH
Discussion Leader: David Kingsley (Stanford University School of Medicine, Stanford, CA, USA)
7:40 pm - 7:50 pm David Kingsley (Stanford University School of Medicine, Stanford, CA, USA)
"Introduction"
7:50 pm - 8:15 pm Tanya Smith (Harvard University, Boston, MA, USA)
"A Primate Perspective on Dental Evolution"
8:15 pm - 8:30 pm Discussion
8:30 pm - 8:40 pm Short Presentation: Elodie Renvoise (Institute of Biotechnology, Helsinki, Finland)
"Developmental Mechanisms in the Evolution Of Morphological Innovation in Small Mammals"
8:40 pm - 8:50 pm Discussion
8:50 pm - 9:15 pm Robert Cerny (Charles University, Prague, Czech Republic)
"Jaw Evolution (prepattern/cooption model): Understanding Evolution of New Skeletal Tissues and Joint
Formation Based on Studies of an Agnathan Vertebrate"
9:15 pm - 9:30 pm Discussion
MONDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm DEVELOPMENTAL MECHANISMS
Discussion Leader: Jerry Feng (Baylor College of Dentistry, TX A&M Health Science Center, Dallas, TX,
USA)
9:00 am - 9:25 am Irma Thesleff (University of Helsinki, Finland)
"Regulation of Dental Patterning by Signal Pathway Modulation"
9:25 am - 9:40 am Discussion

2 of 6 5/25/2011 5:27 AM
Gordon Research Conferences - 2011 Program - Bones & Teeth http://www.grc.org/programs.aspx?year=2011&program=bones

9:40 am - 9:50 am Short Presentation: Nik Kantaputra (Chiang Mai University, Thailand)
"The Smallest Teeth in the World are Caused by Mutations in PCNT Gene"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break / Group Photo
10:30 am - 10:55 am Elazar Zelzer (Weizmann Institute of Science, Israel)
"The Mechanisms that Sculpt our Bones"
10:55 am - 11:10 am Discussion
11:10 am - 11:20 am Short Presentation: Florence Lorget (Biomarin Pharmaceutical Inc., Novato, CA)
"BMN 111, a CNP Analogue, Promotes Skeletal Growth and Rescues Dwarfism in two Transgenic Mouse
Models of Fgfr3-related Chondrodysplasia"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Short Presentation: Jerry Feng (Baylor College of Dentistry, TX A&M Health Science Center, Dallas, TX,
USA)
"Dentinogenesis: A Key Role of ALK3-Osx Signal Pathway"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm Shigeaki Kato (University of Tokyo, Japan)
"Epigenetic Regulators in Osteoclast Development"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm GENETIC MECHANISMS
Discussion Leader: Daniel H. Cohn (University of California, Los Angeles, CA, USA)
5:30 pm - 5:55 pm Deborah Krakow (University of California, Los Angeles, CA, USA)
"Mutations in FKBP65, an ER Localized Protein, Produces OI"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:35 pm André G. Uitterlinden (Erasmus University Medical Center, Rotterdam, The Netherlands)
"Genome - Wide Screens for Skeletal Disease-Genes"
6:35 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Stefan Mundlos (Max Planck Institute for Molecular Genetics, Berlin, Germany)
"Far Far away - Long Range Regulation in Skeletal Development and Disease"
7:15 pm - 7:30 pm Discussion
8:00 pm Dinner
TUESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm POSTNATAL HOMEOSTASIS
Discussion Leader: Thomas L. Clemens (John Hopkins University, Baltimore, MD, USA)
9:00 am - 9:25 am Eileen Shore (University of Pennsylvania, Philadelphia, PA, USA)
"Molecular and Cellular Mechanisms of Ectopic Bone Formation"
9:25 am - 9:40 am Discussion
9:40 am - 9:50 am Short Presentation: Katherine Motyl (Maine Medical Center Research Institute, ME, USA)
"The Second Generation Antipsychotic Risperidone Causes Bone Loss in C57BL/6J Mice as a Result of
Direct and Indirect Effects on Bone Turnover"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am Gerard Karsenty (Columbia University, New York, NY, USA)
"Osteocalcin Functions"
10:55 am - 11:10 am Discussion

3 of 6 5/25/2011 5:27 AM
Gordon Research Conferences - 2011 Program - Bones & Teeth http://www.grc.org/programs.aspx?year=2011&program=bones

11:10 am - 11:20 am Short Presentation: Matthew Grol (The University Of Western Ontario, London, Canada)
"Persistence of ATP-Induced Calcium-NFATc1 Signaling in Osteoblasts is Determined by Distinct
Nucleotide Receptor Subtypes: A Novel Mechanism for Coupling Agonist Concentration to Signal
Duration"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Short Presentation: Stavroula Kousteni (Columbia University, New York, NY, USA)
"FoxO1 in Skeletal Physiology"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm Beate Lanske (Harvard School of Dental Medicine, Boston, MA, USA)
"The Effects of Bone on Kidney and Parathyroid Glands"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 7:30 pm STEM CELLS AND REGENERATIVE MEDICINE/DENTISTRY
Discussion Leader: Jeremy Mao (Columbia University, New York, NY, USA)
5:30 pm - 5:55 pm Pamela G. Robey (NIH/NIDCR, Bethesda, MD, USA)
"Musculoskeletal Stem Cell Biology"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:20 pm Short Presentation: Nick Van Gastel (Katholieke Universiteit, Leuven, Belgium)
"Engineering Vascularized Bone: Osteogenic and Pro-Angiogenic Potential of Murine Periosteal Cells"
6:20 pm - 6:30 pm Discussion
6:30 pm - 6:40 pm Short Presentation: Nicolai Miosge (Tissue Regeneration Work Group, University of Gottingen,
Gottingen, Germany)
"Chondrogenic Progenitor Cells in Osteoarthritis are Regulated by Runx2, Sox9 and Sex Hormones"
6:40 pm - 6:50 pm Discussion
6:50 pm - 7:15 pm Kristi S. Anseth (University of Colorado, CO, USA)
"Programmable Hydrogel Niches for MSC Culture and Differentiation"
7:15 pm - 7:30 pm Discussion
8:00 pm Dinner
WEDNESDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm OSTEOPOROSIS
Discussion Leader: Roland Baron (Harvard School of Dental Medicine, Boston, MA, USA)
9:00 am - 9:25 am Chris Paszty (Amgen Inc., Thousand Oaks, CA, USA)
"Sclerostin: From Gene Discovery to Bone Building Antibodies"
9:25 am - 9:40 am Discussion
9:40 am - 9:50 am Short Presentation: Rao V. Papineni (Carestream Health Inc, Woodbridge, CT, USA)
"Bisphosphonates: A Targetable Theragnostic Agent with no Bone of Contention"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am Mathew Warman (Children's Hospital Boston, Boston, MA, USA)
"Genetic Studies of Musculoskeletal Disease Mechanisms"
10:55 am - 11:10 am Discussion
11:10 am - 11:20 am Short Presentation: Johannes Keller (University Medical Center Hamburg-Eppendorf, Hamburg,
Germany)
"Control of Bone Formation by the Calcitonin Receptor in Osteoclasts"
11:20 am - 11:30 am Discussion

4 of 6 5/25/2011 5:27 AM
Gordon Research Conferences - 2011 Program - Bones & Teeth http://www.grc.org/programs.aspx?year=2011&program=bones

11:30 am - 11:40 am Short Presentation: Leonie Huitema (Hubrecht Institute, Utrecht, Netherlands)
"A Novel Ectonucleotidase Essential for Bone Formation in Fish"
11:40 pm - 11:50 am Discussion
11:50 am - 12:15 pm Alexander G. Robling (Indiana University School of Medicine, Indianapolis, IN, USA)
"Lrp5 Signaling in Bone: Local Regulation of Bone Metabolism and Mechanotransduction"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time
4:00 pm - 5:30 pm Poster Session
5:30 pm - 6:50 pm CANCER
Discussion Leader: Theresa A. Guise (Indiana University School of Medicine, Indianapolis, IN, USA)
5:30 pm - 5:55 pm Yibin Kang (Princeton University, Princeton, NJ, USA)
"Novel Mediators of Tumor-Stromal Interactions in Bone Metastasis"
5:55 pm - 6:10 pm Discussion
6:10 pm - 6:35 pm David M. Thomas (Peter MacCallum Cancer Centre, East Melbourne, Australia)
"Basic and Clinical Studies in Benign and Malignant Bone Tumors"
6:35 pm - 6:50 pm Discussion
6:50 pm - 8:00 pm Business Meeting
Nominations for the next Vice Chair; Fill out Conference Evaluation Forms; Discuss future Site &
Scheduling preferences; Election of the next Vice Chair
8:00 pm Dinner
THURSDAY
7:30 am - 8:30 am Breakfast
9:00 am - 12:30 pm BONES AND TEETH: JOINTS AND SOFT TISSUE CONNECTIONS
Discussion Leader: Yingzi Yang (National Human Genome Research Institute, Bethesda, MD, USA)
9:00 am - 9:25 am Malcolm Logan (National Institute for Medical Research, London, UK)
"Mechanisms Controlling Morphogenesis of Limb Tissues"
9:25 am - 9:40 am Discussion
9:40 am - 9:50 am Short Presentation: April Craft (University Health Network, Toronto, ON, Canada)
"Regulation of Articular and Growth Plate Chondrocytes from Pluripotent Stem Cells"
9:50 am - 10:00 am Discussion
10:00 am Coffee Break
10:30 am - 10:55 am Ronen Schweitzer (Shriners Hospital for Children, Portland, OR, USA)
"From Salamander to Mouse - Generation of Long Tendons by Scleraxis Dependent Elongation of
Sox9-Lineage Derived Tendon Precursors"
10:55 am - 11:10 am Discussion
11:10 am - 11:20 am Short Presentation: George Yang (Stanford University, CT, USA)
"Cartilage-related Phenotype in DEL1 Knockout Mice"
11:20 am - 11:30 am Discussion
11:30 am - 11:40 am Short Presentation: Gilbert Weidinger (Technische Universität Dresden, Dresden, Germany)
"Bone Regenerates via Dedifferentiation of Osteoblasts in the Zebrafish Fin"
11:40 am - 11:50 am Discussion
11:50 am - 12:15 pm Maurizio Pacifici (Thomas Jefferson University, Philadelphia, PA, USA)
"Hox Genes Control Morphogenesis and Organization of Mouse Limb Synovial Joints"
12:15 pm - 12:30 pm Discussion
12:30 pm Lunch
1:30 pm - 4:00 pm Free Time

5 of 6 5/25/2011 5:27 AM
Gordon Research Conferences - 2011 Program - Bones & Teeth http://www.grc.org/programs.aspx?year=2011&program=bones

4:00 pm - 5:30 pm Poster Session

5:30 pm - 7:30 pm KEYNOTE LECTURES: EVOLUTIONARY GAIN AND LOSS OF SKELETAL
ELEMENTS
Discussion Leader: Fanxin Long (Washington University Medical School, St. Louis, MO, USA)
5:30 pm - 6:15 pm Jennifer A. Clack (University Museum of Zoology, Cambridge, UK)
"Bone Construction and Evolution in the Earliest Tetrapods"
6:15 pm - 6:30 pm Discussion
6:30 pm - 7:15 pm David Kingsley (Stanford University School of Medicine, Stanford, CA, USA)
"Fishing for the Secrets of Vertebrate Evolution"
7:15 pm - 7:30 pm Discussion
8:00 pm Dinner
FRIDAY
7:30 am - 8:30 am Breakfast
9:00 am Departure

Funding for this conference was made possible (in part) by (1 R13AR061249-01) from NIAMS. The views expressed in written
conference materials or publications and by speakers and moderators do not necessarily reflect the official policies of the
Department of Health and Human Services; nor does mention by trade names, commercial practices, or organizations imply
endorsement by the U.S. Government.

Last Updated: May 24, 2011

6 of 6 5/25/2011 5:27 AM