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GESTATIONAL
DIABETES
MELLITUS
SUBGROUP A6 | Cabujat to Catral
OUTLINE
CASE
PRESENTATION Salient Features Gaps in Knowledge Classification
DIAGNOSTICS &
OUTCOMES Screening Tests Diagnostic Work-up Perinatal Outcomes
MANAGEMENT
PLAN Non-Pharmacologic Pharmacologic Obstetric & Discharge
SUBJECTIVE
SALIENT
FEATURES IDENTIFYING DATA
Z.D., 36 years old, G3P2 (2002), married, Filipino,
Roman Catholic from Cupang Antipolo City, admitted
for the first time at UERMMMC last November 4, 2019.
OBJECTIVE
CHIEF COMPLAINT
Labor pains of 3 hours duration
COURSE
SUBJECTIVE
SALIENT
FEATURES HISTORY OF PRESENT ILLNESS
3 hours PTA → Mild to moderate uterine
contractions occurring regularly every 2-3 minutes
lasting for 30-40 seconds, (+) spotting, (-) watery
OBJECTIVE
vaginal discharge
Prompted consult at UERM consultation room →
examined and admitted for Emergency Low
Transverse Cesarean Section
COURSE
SUBJECTIVE
SALIENT
FEATURES Menstrual History
Menarche: 12 years old
Menstrual cycle: Regular 28-30 day cycles lasting 3
days consuming 2-3 pads per day, moderately soaked
OBJECTIVE
(-) Dysmenorrhea
COURSE
SUBJECTIVE
SALIENT
FEATURES OBSTETRIC HISTORY
G3P2 (2002)
G1 - 2005, delivered a live full term boy via LTCCS I
secondary to cephalopelvic disproportion at Queen Mary
OBJECTIVE
Hospital, BW 3318g.
G2 - 2011, delivered a live full term girl via Elective LTCCS
II for repeat at UERMMMCI, BW 2818g ; GDM on insulin
therapy diagnosed at early pregnancy. Glucose levels
normalized after pregnancy.
COURSE
G3 - present pregnancy, 38 4/7 wks AOG via LMP, EDD
November 14, 2019, poor prenatal check up.
SUMMARY OF PRENATAL CHECK-UP
DATE & AOG FINDINGS/ ASSESSMENT PLAN
OBJECTIVE
Sexually transmitted infections
Pruritus
Abnormal vaginal discharge
COURSE
SUBJECTIVE
SALIENT
FEATURES SEXUAL HISTORY
Coitarche at 20 years old, 1 sexual partner
No dyspareunia, no post-coital bleeding
OBJECTIVE
CONTRACEPTIVE HISTORY
No history of contraceptives use
COURSE
diseases, or obesity
SUBJECTIVE
SALIENT
FEATURES family medical HISTORY
Hypertension - paternal side
Diabetes Mellitus - maternal side
OBJECTIVE
SOCIAL History
Occupation: Pharmacy assistant since 4 years ago
Occasional alcoholic beverage drinker
Non-smoker
Diet pre-pregnancy: 1 cup of rice per day
COURSE
Diet during pregnancy: 2-3 cups of rice per day and a viand
No regular exercise
SUBJECTIVE
SALIENT
FEATURES PHYSICAL EXAM ON ADMISSION
General
Patient is conscious, coherent, not in cardio-respiratory distress
Appearance
OBJECTIVE
Vital Signs BP: 120/60mmHg > HR :90bpm > RR :18cpm > T: 36.7 °C > BMI: 32.05 (Obese)
Anicteric sclerae, pink palpebral conjunctivae, pupils equally round and briskly
reactive to light, full EOMs, no ptosis, no eye discharge; well-formed pinna, no
Head and Neck
tonsillopharyngeal congestion; trachea is at midline; thyroid is not enlarged, no
COURSE
cervical lymphadenopathies.
Chest and Lungs Equal chest expansion, clear breath sounds bilaterally, no retractions
SUBJECTIVE
SALIENT
FEATURES PHYSICAL EXAM ON ADMISSION
Heart Adynamic precordium, normal rate, regular rhythm, distinct S1 and S2, no murmurs
OBJECTIVE
Globular, Gravid uterus (+) linea nigra (+) scar
Abdomen L1 - Breech > L2 - Fetal back is on maternal right > L3 - Cephalic, unengaged
FH - 38cm ; EFBW: 4,030g; FHT - 140s
Pelvic Internal exam: cervix 3 cm dilated, 50% effaced, cephalic, station -3, intact membrane
Full and equal pulses, capillary refill time <2 seconds, no cyanosis, (-) bipedal edema,
COURSE
Extremities
full range of motion
Heart Adynamic precordium, normal rate, regular rhythm, distinct S1 and S2, no murmurs
SUBJECTIVE
SALIENT
FEATURES COURSE IN THE WARDS
On admission, patient has stable vital signs with
contractions noted to be moderate, occurring every
OBJECTIVE
3 minutes lasting for 30-40 seconds. Baseline CBG
was 111 mg/dl. HbA1c was also requested showing
normal value (5.6%). Patient was referred to DM
service for co-management. CBC was also
COURSE
requested which revealed normal result and
Hepatitis B Profile with reactive anti-HBc.
SUBJECTIVE
SALIENT
FEATURES admitting diagnosis
OBJECTIVE
labor, advance maternal age, GDM, unknown control, lost to follow-up,
Acute vs Chronic Hepatitis B infection, s/p LTCCS secondary to
cephalopelvic disproportion (2005) and Elective CS (2011)
COURSE
classification of diabetes
mellitus in pregnancy
gestational dm (gdm)
Carbohydrate intolerance of variable severity with its onset
or first recognition during pregnancy
Induced by exagerated physiological changes in glucose
metabolism
More than 50% of women with GDM ultimately develop overt
diabetes in the next 20 years
classification of diabetes
mellitus in pregnancy
classification of diabetes
mellitus in pregnancy
NORMAL PREGNANCY VS. GESTATIONAL DM
SCREENING FOR
GESTATIONAL DIABETES
≥ 153 mg/dl
2-hour ≥ 155 mg/dl ≥ 153 mg/dl
Criteria for
At least 2 At least 1 At least 1
Diagnosis
DIAGNOSTIC
WORK-UP
Acute Hep A Acute Hep B Acute Hep C
HBsAg _ + _
HCV- RNA - - +
SUBJECTIVE
case Test Results of the Patient
follow-up
BLOOD FASTING: 105.4 mg/dl
Blood 1 hr: 135mg/dl
working DIAGNOSIS Blood 2 hours: 102 mg/dl
G3P2 (2002) pregnancy uterine 38 Baseline CBG: 111 mg/dl
OBJECTIVE
4/7 AOG by LMP, cephalic in labor HbA1c: 5.6%
EFBW 4030kg (LGA); obese class 1,
GDM unknown control, acute vs. HBsAg: Reactive
chronic Hepatitis B infection, Hepatitis B profile with reactive anti-Hbc
COURSE
cephalopelvic disproportion (2005)
and Elective CS (2011), AMA
PERINATAL
MATERNAL OUTCOMES
OUTCOMES
Overt Diabetes GDM
Glycated
6.8 ± 1.1% 5.8 ± 0.5%
Hemogblobin
PERINATAL
MATERNAL OUTCOMES
OUTCOMES
Overt Diabetes GDM
15-20% (T1DM);
Pre-eclampsia 6.1% (IR)
10-14% (T2DM) (IR)
Risk of Primary C-
2.5X increased risk 1.8X increased risk
section
PERINATAL
MATERNAL OUTCOMES
OUTCOMES
Overt Diabetes GDM
Gestational age at
37.8 ± 2.5 weeks 38.1 ± 2.1 weeks
delivery
Prevalence of
1.2% 0%
Retinopathy
Prevalence of
8.6% 6.5%
Symptomatic UTI
PERINATAL
OUTCOMES
Altered Fetal Macrosomia: 40% inc. risk Macrosomia: 30% inc. risk
Growth IUGR: 10% inc. risk
Preterm
3.34 (OR) 1.69 (OR)
Delivery
Spontaneous abortion
Other Similar outcomes as in Overt
Unexplained fetal demise
Outcomes DM but with decreased risk
Hydramnios
Respiratory Distress
Syndrome
Other Similar outcomes as in Overt
Polycythemia
Outcomes DM but with decreased risk
Hyperbilirubinemia
Cardiomyopathy
LONG-TERM OUTCOMES
Long-term cognitive development
Autism spectrum disorders
ADHD
Developmental delays
Inheritance of Diabetes
Obesity
Adiposity
Adnormal glucose metabolism
Williams (25th ed.)
Riskin, A. & Prats, J. (2020, Feb 10). Infants of Women with Diabetes. UpToDate. Retrieved from https://www.uptodate.com/contents/infants-of-women-with-diabetes
MANAGEMENT NON-PHARMACOLOGIC TREATMENT
PLAN LIFESTYLE MODIFICATION
DIET
EXERCISE
MANAGEMENT NON-PHARMACOLOGIC TREATMENT
PLAN NUTRITION THERAPY
GOALS
Achieve normoglycemia
Prevent ketosis
Provide adequate nutrition and weight gain based on
maternal BMI
Contribute to appropriate fetal growth and
development
MANAGEMENT NON-PHARMACOLOGIC TREATMENT
PLAN NUTRITION THERAPY
Padayachee C, Coombes JS. Exercise guidelines for gestational diabetes mellitus. World J Diabetes. 2015 Jul 25;6(8):1033-44. doi:
10.4239/wjd.v6.i8.1033. PMID: 26240700; PMCID: PMC4515443.
MANAGEMENT NON-PHARMACOLOGIC TREATMENT
PLAN BREASTFEEDING
Improves maternal glucose metabolism
May reduce the glucose levels obtained during a
postpartum glucose tolerance test (GTT)
Significantly reduced maternal risk of developing
type 2 diabetes later in life
MANAGEMENT PHARMACOLOGICAL TREATMENT
PLAN GOALS OF TREATMENT
1/3 regular insulin and 2/3 NPH 1/2 regular insulin and 1/2 NPH
MANAGEMENT PHARMACOLOGICAL TREATMENT
PLAN ORAL HYPOGLYCEMIC AGENTS
Promotes closure of K-channels in pancreatic B cell Inhibits hepatic and renal gluconeogenesis →
MOA
→
membrane stimulate endogenous insulin release reduces postprandial and fasting glucose levels
https://www.uptodate.com/contents/gestational-diabetes-mellitus-obstetric-issues-and-management
MANAGEMENT OBSTETRIC MANAGEMENT
PLAN INDICATIONS FOR CS
DISCHARGE
INSTRUCTIONS POST-DELIVERY
DM screening at 6-12 weeks postpartum
Lifelong screening for DM every 3 years
Encourage breastfeeding with proper latching,
which decreases maternal risk for subsequent
GDM and overt DM; also decreases fetal risk for
diabetes
DISCHARGE
INSTRUCTIONS POST-DELIVERY
General activities are allowed
Encourage physical activity but not too strenuous
and with enough rest
Maintain proper wound care
Well-balanced diet with good fiber and fluid intake
Stool softeners
Counseling about weight loss and family planning
ank you
Th !
ARE
THERE AN QUESTIONS?
Y
esources
R
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https://www.uptodate.com/contents/gestational-diabetes-mellitus-obstetric-issues-and-management
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