Mesothelioma: Radiotherapy

Prof. Dirk De Ruysscher

Maastricht University Medical Center
Department of Radiation Oncology (Maastro clinic)
The Netherlands
03/01/13
Prophylactic irradiation
de Perrot et al. Lancet Oncol 2017
03/01/13
Preoperative irradiation before EPP
de Perrot et al. Lancet Oncol 2017
03/01/13
Hemithoracic irradiation before decortication/
pleurectomy
Botticella et al. Strahlenther Onkol
Botticella et al. Ann Oncol 2016
2017
03/01/13
Adjuvant irradiation after decortication/ pleurectomy
de Perrot et al. Lancet Oncol 2017
03/01/13
Adjuvant irradiation after resection
de Perrot et al. Lancet Oncol 2017
03/01/13
Palliative irradiation
de Perrot et al. Lancet Oncol 2017
03/01/13
Palliative irradiation
Phase II trial: n=40
Prim. Endpoint: pain 5 weeks post radiotherapy (20 Gy/ 5 fractions)
MacLeod et al. J Thorac Oncol 2015
03/01/13
Mesothelioma: Conclusions
- No role for prophylactic irradiation of ports
- Pre- or postoperative radiotherapy: only in trials
- Palliative irradiation: Majority of patients respond for pain relief: 20 Gy in 5
fractions
- Future: improvement of systemic treatment is crucial before local treatments
can play a significant curative role
03/01/13