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Ophthalmic & Physiological Optics ISSN 0275-5408

GUEST EDITORIAL

Blue-light filtering ophthalmic lenses: to prescribe, or not to


prescribe?

Although essential to visual perception, light can poten- visible blue light has been suggested to cause eye strain,11
tially act as an ocular hazard. Sunlight comprises of radia- and to potentially promote sleep dysfunction due to a shift
tion from the electromagnetic spectrum, extending from in circadian phase with nighttime blue light exposure.12
the longer wavelengths of the ultraviolet (UV) region Given the frequency and duration of digital device use in
(~290 nm) to the far infrared. Importantly, the natural modern society, should blue-light exposure be a public
absorbance characteristics of the eye limit the amount of health concern?
potentially damaging radiation that can reach the retina. Over the past decade, there has been heightened interest
The cornea absorbs UV radiation below 300 nm1 and the amongst researchers, the optical industry and eye care clini-
crystalline lens attenuates the transmission of most wave- cians in relation to ophthalmic lenses that have blue-light
lengths between 300 and 400 nm, particularly those up to filtering properties. A PubMed search of the keywords
360 nm.1,2 With advancing age, and an associated physio- ‘blue-block*’ or ‘blue-light filter*’ reveals that since 2008
logic yellowing of the crystalline lens, there is a relatively there has been a notable increase in the number of publica-
increased degree of attenuation of blue light transmission; tions focusing on this topic (Figure 2). Blue-light filtering
the aged crystalline lens thus shows blue-light filtering lenses, also termed ‘blue-blocking’ lenses, selectively attenu-
properties.3 The macular pigments, lutein and zeaxanthin, ate the transmission of both UV light (involving wave-
are also proposed to impart retinoprotection by absorbing lengths in the 200 to 400 nm range), and short-wavelength
short-wavelength visible light.4 visible light (including violet light: 380 to 440 nm and blue
It is retinal exposure to shorter-wavelength visible light light: 440 to 500 nm). These ophthalmic devices, which
(400 to 500 nm), being of relatively higher energy than visi- include both intra-ocular lenses (IOLs) and spectacle
ble light of other wavelengths, which forms the basis for the lenses, may contain, or be coated with, chromophores that
so-called ‘blue-light hazard’ (Figure 1a). Data from cell absorb incident short-wavelength light; the extent of atten-
culture experiments5–7 and animal studies8 demonstrate uation depends upon the specific absorbance properties of
that short-wavelength visible light can induce phototoxic the chromophore. An alternative approach involves the
retinal damage. Extrapolating these empirical findings, application of anti-reflective interference coatings to the
international standards were developed to define safety ophthalmic lens surfaces, to selectively reduce the transmis-
limits relating to blue-light ocular exposure in humans.9 sion of regions of the violet-blue spectrum. In addition,
However, the past decade has witnessed dramatic changes some digital devices offer the option of blue-light filtering
to the adoption of a range of modern light sources, in both ‘night’ settings, which reduce the emission of short-wave-
domestic and commercial settings; in particular, there has length light, with the intent of limiting evening blue light
been significantly increased use of light emitting diodes exposure, to improve subsequent sleep quality.
(LEDs) and compact fluorescent lamps, which emit A range of marketing claims13 have been made with
relatively higher levels of blue light than traditional respect to the potential benefits of blue-light spectacle fil-
incandescent sources.10 Furthermore, white-light LEDs, ters, including the alleviation of eyestrain and ocular dis-
which are currently utilised in the backlit displays of tablet comfort associated with digital device use,14,15 improving
computers, laptops and smartphones, show weighted peak sleep quality16 and protection from retinal phototoxicity.13
spectral emissions at wavelengths that correspond to the Blue-light filtering IOLs, which more closely mimic the
peak of the blue-light hazard function (Figure 1b). light transmission characteristics of the ageing human crys-
Reassuringly, recent research suggests that even under talline lens compared with UV-filtering IOLs, have been
extreme, long-term viewing conditions, the level of blue- proposed to potentially protect against retinal damage fol-
light exposure from computer screens and mobile devices lowing cataract surgery. Proponents for such filters suggest
is significantly less than the levels of blue-light exposure that the attenuation of short-wavelength visible light could
from natural daylight, and further, such exposures do not prevent or slow the progression of age-related macular
approach international safety limits.10 However, in addi- degeneration (AMD); currently, there are insufficient clini-
tion to potential retinal damage, exposure to short-wave- cal data to support this position.17,18
length light has been suggested to yield other clinically As previously detailed, the argument for photoprotection
significant effects. For example, excessive exposure to with blue-light filters is theoretical and/or based upon

640 © 2017 The Authors Ophthalmic & Physiological Optics © 2017 The College of Optometrists
Ophthalmic & Physiological Optics 37 (2017) 640–643
Guest Editorial

Figure 1. (a) Diagram of the blue light hazard function, which plots the relative effectiveness of optical radiation to produce retinal damage as a
function of wavelength. (b) Blue light weighted spectral radiance from incandescent (orange plot) and light emitting diode (purple plot) light sources,
after applying the blue light hazard weighting. Adapted from O’Hagan and colleagues (2016).10

finding may have broader implications for the prescribing


of short-wavelength attenuating filters to children at risk of
myopia development and/or progression.
Recently, questions have been raised, within both the
popular press21,22 and scientific literature,10,23 regarding
whether there is sufficient evidence to support specific
claims that have been made in relation to the beneficial
effects of blue-light filtering ophthalmic lenses. In the Uni-
ted Kingdom (UK) there has been significant controversy
surrounding the promotion, by some optical companies, of
blue-light filtering spectacle lenses for what was deemed
“unproven health claims”.24 In 2015, the UK Advertising
Standards Authority (ASA) found that a national press
advertisement from an optical retailer promoting the use of
Figure 2. Number of publications in PubMed resulting from a search
a blue-light filtering spectacle lens product to consumers to
of the keywords ‘blue-block*’ or ‘blue-light filter*’.
“filter out harmful blue light” constituted misleading
advertising “in the absence of adequate substantiation”
in vitro studies or laboratory-based experiments, rather linking blue light exposure to retinal damage in clinical
than clinical studies. Thus, while the rationale for using populations.25 As a result of the ASA ruling, the advertise-
blue-light filtering ophthalmic devices has scientific plausi- ment was prohibited from being reused in its original form.
bility, there is significant debate with respect to the merit of Furthermore, in 2016, the British Broadcasting Corpora-
these products for imparting retinal protection and/or their tion (BBC) undertook an undercover investigation, as part
other purported benefits in clinical populations. Further- of the consumer protection television program Watchdog,
more, the possible benefits of these devices needs to be con- to investigate health claims being made to consumers by
sidered in the context of any possible harms, which have selected optical retailers in relation to the benefits of blue-
been suggested to potentially include alterations to colour light filtering spectacle lenses. The program, which aired on
perception, reduced scotopic sensitivity and disruptions to television in the UK in November 2016, expressed concerns
circadian rhythms.19 Such factors are particularly relevant about “misleading” advice that was provided in relation to
given that the prescription of a blue-light filtering spectacle the influence of blue light, emitted from digital devices,
lens is typically at additional expense (beyond the cost of a promoting eye strain and visual fatigue.24
non-blue light filtering lens) to the consumer. Most There is arguably a need for improved guidance for
recently, the potential protective effect of violet visible light clinicians in relation to the appropriateness of prescribing
for reducing myopia progression in an animal model has ophthalmic devices that selectively attenuate short wave-
been reported;20 if shown to be consistent in humans, this length light. In Australia, clinical guidelines are being

© 2017 The Authors Ophthalmic & Physiological Optics © 2017 The College of Optometrists 641
Ophthalmic & Physiological Optics 37 (2017) 640–643
Guest Editorial

developed to assist optometrists with providing evidence- ophthalmic lenses remain consistent with the current, best-
based advice to their patients in relation to blue-light fil- available clinical research evidence.
tering spectacle coatings.26 The authors of these guidelines
have indicated that recommendations will consider both
Disclosure
the universal applicability of blue-light filters (for prescrip-
tion to the general population), as well as their potential The author does not have any conflicts of interest relating
suitability for ‘at risk’ populations.26 With respect to oph- to the content of this editorial.
thalmology, a Cochrane systematic review is currently in
progress to assess evidence relating to the effects of blue- Laura E Downie
light filtering IOLs for protecting macular health following Department of Optometry & Vision Sciences,
cataract phacoemulsification surgery.27 University of Melbourne, Melbourne, Australia
Recognising the urgent need for a similar evaluation of E-mail address: ldownie@unimelb.edu.au
the best available clinical research evidence relating to
blue-light spectacle filters, in the current issue of Oph- References
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642 © 2017 The Authors Ophthalmic & Physiological Optics © 2017 The College of Optometrists
Ophthalmic & Physiological Optics 37 (2017) 640–643
Guest Editorial

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Dr Laura Downie is a Senior Lecturer and a recent National Health and


Medical Research Council (NHMRC) Translating Research Into Practice Fel-
low in the Department of Optometry and Vision Sciences at the University
of Melbourne, Victoria, Australia. She completed her undergraduate optom-
etry degree (2003) and doctorate (2008) at the University of Melbourne. In
her current role, she provides didactic and clinical training to Doctor of
Optometry students, leads the specialty Cornea clinic at University of Mel-
bourne eye care clinic and heads the Downie Laboratory: Anterior Eye, Clini-
cal Trials and Research Translation Unit. A major component of her research
focuses upon the translation of evidence into practice in the context of eye
health, including the role of diet and nutritional supplementation as modifi-
able risk factors for sight-threatening eye conditions, such as age-related
macular degeneration. In 2014, she was awarded two prestigious fellowships
from the NHMRC and achieved international recognition for her research as
recipient of the Irvin M. and Beatrice Borish Award from the American
Academy of Optometry.

© 2017 The Authors Ophthalmic & Physiological Optics © 2017 The College of Optometrists 643
Ophthalmic & Physiological Optics 37 (2017) 640–643

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